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Gadd45a growth arrest and DNA-damage-inducible, alpha [ Rattus norvegicus (Norway rat) ]

Gene ID: 25112, updated on 18-Sep-2024

Summary

Official Symbol
Gadd45aprovided by RGD
Official Full Name
growth arrest and DNA-damage-inducible, alphaprovided by RGD
Primary source
RGD:2654
See related
EnsemblRapid:ENSRNOG00000005615 AllianceGenome:RGD:2654
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ddit1; Gadd45
Summary
Predicted to enable several functions, including promoter-specific chromatin binding activity; protein N-terminus binding activity; and protein dimerization activity. Involved in G2/M transition of mitotic cell cycle. Predicted to be located in nuclear speck. Predicted to be active in cytoplasm and nucleus. Orthologous to human GADD45A (growth arrest and DNA damage inducible alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 275.4), Kidney (RPKM 270.2) and 9 other tissues See more
Orthologs
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Genomic context

See Gadd45a in Genome Data Viewer
Location:
4q31
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (97484497..97486799, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (96154789..96157091, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (97782512..97784814, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene vomeronasal 1 receptor 89 Neighboring gene G protein subunit gamma 12 Neighboring gene uncharacterized LOC100912188 Neighboring gene uncharacterized LOC120102291 Neighboring gene Serpine1 mRNA binding protein 1 Neighboring gene interleukin 12 receptor subunit beta 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables kinase binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables promoter-specific chromatin binding IEA
Inferred from Electronic Annotation
more info
 
enables promoter-specific chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in DNA damage response IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA damage response TAS
Traceable Author Statement
more info
PubMed 
involved_in G2/M transition of mitotic cell cycle IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to ionizing radiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to mechanical stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in centrosome cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within centrosome cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of blood vessel endothelial cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of peptidyl-serine phosphorylation of STAT protein IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of peptidyl-serine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of JNK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of p38MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of p38MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of reactive oxygen species metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction in response to DNA damage IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction in response to DNA damage ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
growth arrest and DNA damage-inducible protein GADD45 alpha
Names
DDIT-1
DNA damage-inducible transcript 1 protein
DNA-damage-inducible transcript 1
growth arrest and DNA-damage-inducible 45 alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024127.2NP_077041.2  growth arrest and DNA damage-inducible protein GADD45 alpha

    See identical proteins and their annotated locations for NP_077041.2

    Status: PROVISIONAL

    Source sequence(s)
    BC081795
    UniProtKB/Swiss-Prot
    P48317
    UniProtKB/TrEMBL
    B2DBD9, Q66HL6
    Related
    ENSRNOP00000007698.3, ENSRNOT00000007698.8
    Conserved Domains (1) summary
    pfam01248
    Location:21105
    Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    97484497..97486799 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)