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Foxa3 forkhead box A3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25100, updated on 6-Jul-2026
Official Symbol
Foxa3provided by RGD
Official Full Name
forkhead box A3provided by RGD
Primary source
RGD:2809
See related
AllianceGenome:RGD:2809
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Hnf3g
Summary
Enables DNA binding activity and DNA-binding transcription factor activity. Involved in several processes, including negative regulation of cell population proliferation; positive regulation of hepatocyte differentiation; and positive regulation of transcription by RNA polymerase II. Predicted to be located in actin cytoskeleton and nucleoplasm. Orthologous to human FOXA3 (forkhead box A3). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Liver (RPKM 197.7) and Testes (RPKM 29.0) See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See Foxa3 in Genome Data Viewer
Location:
1q21
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (87790111..87800259, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (78662067..78672321, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene Myb-related transcription factor, partner of profilin Neighboring gene interferon regulatory factor 2 binding protein 1 Neighboring gene symplekin scaffold protein Neighboring gene transfer RNA glycine (anticodon ACC) 6 Neighboring gene radial spoke head 6 homolog A

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Forkhead box A3 attenuated the progression of fibrosis in a rat model of biliary atresia. Dong R, et al. Cell Death Dis, 2017 Mar 30. PMID 28358366, Free PMC Article
  2. Adenovirus-transferred HNF-3 gamma conserves some liver functions in primary cultured hepatocytes of adult rats. Nakamura T, et al. Biochem Biophys Res Commun, 1998 Dec 18. PMID 9878541
  3. Gene expression of the three members of hepatocyte nuclear factor-3 is differentially regulated by nutritional and hormonal factors. Imae M, et al. J Endocrinol, 2000 Oct. PMID 11018767
  4. Induction of Functional Hepatocyte-Like Cells by Overexpression of FOXA3 and HNF4α in Rat Bone Marrow Mesenchymal Stem Cells. Dai K, et al. Cells Tissues Organs, 2014. PMID 25896100
  5. The role of HNF1alpha, HNF3gamma, and cyclic AMP in glucose-6-phosphatase gene activation. Lin B, et al. Biochemistry, 1997 Nov 18. PMID 9369482

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. [Combinational Overexpression of Foxa3 and Hnf4alpha Enhance the Proliferation and Prolong the Functional Maintenance of Primary Hepatocytes].
    Title: [Combinational Overexpression of Foxa3 and Hnf4α Enhance the Proliferation and Prolong the Functional Maintenance of Primary Hepatocytes].
  2. data suggested a protection role for Foxa3 during the progression of liver fibrosis in biliary atresia, and thereby supported increasing Foxa3 as a targeted treatment strategy.
    Title: Forkhead box A3 attenuated the progression of fibrosis in a rat model of biliary atresia.
  3. FOXA3 and HNF4alpha are powerful transcription factors for inducing rat bone marrow mesenchymal stem cells to differentiate into functional hepatocyte-like cells.
    Title: Induction of Functional Hepatocyte-Like Cells by Overexpression of FOXA3 and HNF4α in Rat Bone Marrow Mesenchymal Stem Cells.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA binding TAS
Traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein domain specific binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in anatomical structure morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cellular response to starvation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within hematopoietic stem cell homeostasis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within intracellular glucose homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular glucose homeostasis TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of hepatocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in response to nutrient levels IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
hepatocyte nuclear factor 3-gamma
Names
HNF-3-gamma
HNF-3G
forkhead box protein A3

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001433737.1 → NP_001420666.1  hepatocyte nuclear factor 3-gamma isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    P32183

  2. NM_017077.3 → NP_058773.2  hepatocyte nuclear factor 3-gamma isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    P32183

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    87790111..87800259 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039101386.2 → XP_038957314.1  

    Conserved Domains (1) summary
    cd20040
    Location:124 → 225
    FH_FOXA3; Forkhead (FH) domain found in Forkhead box protein A3 (FOXA3) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32183.1 GenPept UniProtKB/Swiss-Prot:P32183

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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