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Th tyrosine hydroxylase [ Rattus norvegicus (Norway rat) ]

Gene ID: 25085, updated on 19-Sep-2021

Summary

Official Symbol
Thprovided by RGD
Official Full Name
tyrosine hydroxylaseprovided by RGD
Primary source
RGD:3853
See related
Ensembl:ENSRNOG00000020410
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
The
Summary
catalyzes the rate limiting step in catecholamine biosynthesis; may be involved in response to hypoxia [RGD, Feb 2006]
Expression
Restricted expression toward (RPKM 273.3) See more
Orthologs
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Genomic context

Location:
1q41
Exon count:
13
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (198071500..198078832, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (216073034..216080287, complement)

Chromosome 1 - NC_051336.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100909737 Neighboring gene vegetative cell wall protein gp1-like Neighboring gene insulin-like growth factor 2 Neighboring gene insulin 2 Neighboring gene uncharacterized LOC108349673 Neighboring gene uncharacterized LOC120099959 Neighboring gene uncharacterized LOC120099960 Neighboring gene achaete-scute family bHLH transcription factor 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables amino acid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables amino acid binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables dopamine binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables ferric iron binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ferrous iron binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding TAS
Traceable Author Statement
more info
PubMed 
enables monooxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables oxygen binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables tetrahydrobiopterin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables tyrosine 3-monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables tyrosine 3-monooxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables tyrosine 3-monooxygenase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in aminergic neurotransmitter loading into synaptic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within animal organ morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in catecholamine biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to alkaloid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to glucose stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to growth factor stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to manganese ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to nicotine IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cerebral cortex development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in circadian sleep/wake cycle IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cognition IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in dopamine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in dopamine biosynthetic process from tyrosine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in dopamine biosynthetic process from tyrosine IDA
Inferred from Direct Assay
more info
PubMed 
involved_in dopamine biosynthetic process from tyrosine IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within dopamine biosynthetic process from tyrosine ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within eating behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in embryonic camera-type eye morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in epinephrine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in eye photoreceptor cell development ISO
Inferred from Sequence Orthology
more info
 
involved_in fatty acid metabolic process IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in glycoside metabolic process IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in heart development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in heart development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within heart development ISO
Inferred from Sequence Orthology
more info
 
involved_in hyaloid vascular plexus regression ISO
Inferred from Sequence Orthology
more info
 
involved_in hyaloid vascular plexus regression ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in isoquinoline alkaloid metabolic process IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within learning ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within locomotory behavior ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mating behavior ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within memory ISO
Inferred from Sequence Orthology
more info
 
involved_in multicellular organism aging IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in neurotransmitter biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in norepinephrine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in phthalate metabolic process IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in phytoalexin metabolic process IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within regulation of heart contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in response to activity IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to amphetamine IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to corticosterone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to electrical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to ethanol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to ethanol ISO
Inferred from Sequence Orthology
more info
 
involved_in response to ether IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to growth factor IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to herbicide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to hypoxia IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in response to immobilization stress IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to insecticide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to isolation stress IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to light stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to metal ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to nicotine IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to nutrient levels IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to peptide hormone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to pyrethroid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to salt stress IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to steroid hormone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to water deprivation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to zinc ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in sensory perception of sound IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in social behavior IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in sphingolipid metabolic process IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within synaptic transmission, dopaminergic ISO
Inferred from Sequence Orthology
more info
 
involved_in terpene metabolic process IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in visual perception ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in melanosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection terminus ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in perikaryon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in perikaryon IDA
Inferred from Direct Assay
more info
PubMed 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in smooth endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in terminal bouton IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tyrosine 3-monooxygenase
Names
tyrosine 3-hydroxylase
NP_036872.1
XP_038957248.1
XP_038957252.1
XP_038957255.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012740.4NP_036872.1  tyrosine 3-monooxygenase

    See identical proteins and their annotated locations for NP_036872.1

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000044
    UniProtKB/Swiss-Prot
    P04177
    Related
    ENSRNOP00000027682.3, ENSRNOT00000027682.5
    Conserved Domains (3) summary
    cd04930
    Location:38158
    ACT_TH; ACT domain of the nonheme iron-dependent aromatic amino acid hydroxylase, tyrosine hydroxylases (TH)
    pfam00351
    Location:165495
    Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase
    pfam12549
    Location:226
    TOH_N; Tyrosine hydroxylase N terminal

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051336.1 Reference mRatBN7.2 Primary Assembly

    Range
    198071500..198078832 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039101324.1XP_038957252.1  tyrosine 3-monooxygenase isoform X2

    Conserved Domains (3) summary
    pfam00351
    Location:141471
    Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase
    pfam12549
    Location:226
    TOH_N; Tyrosine hydroxylase N terminal
    cl09141
    Location:47134
    ACT; ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme
  2. XM_039101327.1XP_038957255.1  tyrosine 3-monooxygenase isoform X3

    Conserved Domains (3) summary
    pfam00351
    Location:132462
    Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase
    pfam12549
    Location:226
    TOH_N; Tyrosine hydroxylase N terminal
    cl09141
    Location:38125
    ACT; ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme
  3. XM_039101320.1XP_038957248.1  tyrosine 3-monooxygenase isoform X1

    Conserved Domains (3) summary
    cd04930
    Location:47167
    ACT_TH; ACT domain of the nonheme iron-dependent aromatic amino acid hydroxylase, tyrosine hydroxylases (TH)
    pfam00351
    Location:174504
    Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase
    pfam12549
    Location:226
    TOH_N; Tyrosine hydroxylase N terminal
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