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Il4r interleukin 4 receptor [ Rattus norvegicus (Norway rat) ]

Gene ID: 25084, updated on 25-Nov-2021

Summary

Official Symbol
Il4rprovided by RGD
Official Full Name
interleukin 4 receptorprovided by RGD
Primary source
RGD:2899
See related
EnsemblRapid:ENSRNOG00000015441
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Il4ra
Summary
a receptor for the cytokine IL-4 [RGD, Feb 2006]
Expression
Biased expression in Lung (RPKM 136.5), Adrenal (RPKM 114.9) and 9 other tissues See more
Orthologs
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Genomic context

See Il4r in Genome Data Viewer
Location:
1q36
Exon count:
13
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (180115061..180139981)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (196942343..196967221)

Chromosome 1 - NC_051336.1Genomic Context describing neighboring genes Neighboring gene NSE1 homolog, SMC5-SMC6 complex component Neighboring gene uncharacterized LOC103691233 Neighboring gene uncharacterized LOC120097359 Neighboring gene interleukin 21 receptor

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cytokine receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables protein-containing complex binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within defense response to protozoan ISO
Inferred from Sequence Orthology
more info
 
involved_in immune response TAS
Traceable Author Statement
more info
PubMed 
involved_in immunoglobulin mediated immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within immunoglobulin mediated immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in inflammatory response TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within negative regulation of T-helper 1 cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in ovulation IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within positive regulation of T-helper 2 cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of chemokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cold-induced thermogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
acts_upstream_of_or_within positive regulation of immunoglobulin production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of macrophage activation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of mast cell degranulation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of myoblast fusion ISO
Inferred from Sequence Orthology
more info
 
involved_in production of molecular mediator involved in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to estrogen IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to odorant IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
located_in centriolar satellite IEA
Inferred from Electronic Annotation
more info
 
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
interleukin-4 receptor subunit alpha
Names
IL-4 receptor subunit alpha
IL-4R subunit alpha
IL-4R-alpha
IL-4RA
interleukin 4 receptor, alpha
interleukin-4 receptor alpha chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133380.2NP_596871.2  interleukin-4 receptor subunit alpha precursor

    See identical proteins and their annotated locations for NP_596871.2

    Status: VALIDATED

    Source sequence(s)
    AB015747, AW527353, BQ204155
    UniProtKB/Swiss-Prot
    Q63257
    Related
    ENSRNOP00000020994.2, ENSRNOT00000020994.6
    Conserved Domains (2) summary
    cd00063
    Location:123220
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam09238
    Location:32121
    IL4Ra_N; Interleukin-4 receptor alpha chain, N-terminal

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051336.1 Reference mRatBN7.2 Primary Assembly

    Range
    180115061..180139981
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017588804.2XP_017444293.1  interleukin-4 receptor subunit alpha isoform X1

    UniProtKB/Swiss-Prot
    Q63257
    Conserved Domains (2) summary
    cd00063
    Location:123220
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam09238
    Location:32121
    IL4Ra_N; Interleukin-4 receptor alpha chain, N-terminal
  2. XM_006230216.3XP_006230278.1  interleukin-4 receptor subunit alpha isoform X1

    See identical proteins and their annotated locations for XP_006230278.1

    UniProtKB/Swiss-Prot
    Q63257
    Related
    ENSRNOP00000073767.2, ENSRNOT00000088073.2
    Conserved Domains (2) summary
    cd00063
    Location:123220
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam09238
    Location:32121
    IL4Ra_N; Interleukin-4 receptor alpha chain, N-terminal
  3. XM_006230215.4XP_006230277.1  interleukin-4 receptor subunit alpha isoform X1

    See identical proteins and their annotated locations for XP_006230277.1

    UniProtKB/Swiss-Prot
    Q63257
    Conserved Domains (2) summary
    cd00063
    Location:123220
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam09238
    Location:32121
    IL4Ra_N; Interleukin-4 receptor alpha chain, N-terminal
  4. XM_039101306.1XP_038957234.1  interleukin-4 receptor subunit alpha isoform X1

    Conserved Domains (2) summary
    cd00063
    Location:123220
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam09238
    Location:32121
    IL4Ra_N; Interleukin-4 receptor alpha chain, N-terminal
  5. XM_039101307.1XP_038957235.1  interleukin-4 receptor subunit alpha isoform X2

RNA

  1. XR_005499551.1 RNA Sequence

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