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Htr1b 5-hydroxytryptamine receptor 1B [ Rattus norvegicus (Norway rat) ]

Gene ID: 25075, updated on 4-Jun-2020

Summary

Official Symbol
Htr1bprovided by RGD
Official Full Name
5-hydroxytryptamine receptor 1Bprovided by RGD
Primary source
RGD:2846
See related
Ensembl:ENSRNOG00000013042
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
G-protein coupled receptor for serotonin; may have a role in learning and memory [RGD, Feb 2006]
Expression
Biased expression in Brain (RPKM 23.4), Muscle (RPKM 6.9) and 5 other tissues See more
Orthologs

Genomic context

See Htr1b in Genome Data Viewer
Location:
8q31
Exon count:
2
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (89113984..89130830, complement)
106 current Rn_Celera (GCF_000002265.2) 8 AC_000076.1 (82222051..82223211, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 8 NC_005107.3 (88651220..88667993, complement)

Chromosome 8 - NC_005107.4Genomic Context describing neighboring genes Neighboring gene myosin VI Neighboring gene interphotoreceptor matrix proteoglycan 1 Neighboring gene uncharacterized LOC108351750 Neighboring gene uncharacterized LOC102553441 Neighboring gene meiotic double-stranded break formation protein 4

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled serotonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled serotonin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
G protein-coupled serotonin receptor activity ISO
Inferred from Sequence Orthology
more info
 
drug binding IDA
Inferred from Direct Assay
more info
PubMed 
drug binding ISO
Inferred from Sequence Orthology
more info
 
neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
serotonin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
serotonin binding IDA
Inferred from Direct Assay
more info
PubMed 
serotonin binding ISO
Inferred from Sequence Orthology
more info
 
voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels EXP
Inferred from Experiment
more info
PubMed 
voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor internalization ISO
Inferred from Sequence Orthology
more info
 
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
adenylate cyclase-inhibiting serotonin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adenylate cyclase-inhibiting serotonin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
adenylate cyclase-inhibiting serotonin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
bone remodeling ISO
Inferred from Sequence Orthology
more info
 
cellular response to alkaloid ISO
Inferred from Sequence Orthology
more info
 
cellular response to alkaloid ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to drug ISO
Inferred from Sequence Orthology
more info
 
cellular response to drug ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to temperature stimulus ISO
Inferred from Sequence Orthology
more info
 
chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemical synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
drinking behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
feeding behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of gamma-aminobutyric acid secretion IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of serotonin secretion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of serotonin secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of synaptic transmission, GABAergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of synaptic transmission, glutamatergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of vascular smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
presynaptic modulation of chemical synaptic transmission EXP
Inferred from Experiment
more info
PubMed 
presynaptic modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase C-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
regulation of behavior IEA
Inferred from Electronic Annotation
more info
 
regulation of dopamine secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of presynaptic cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
regulation of synaptic vesicle exocytosis EXP
Inferred from Experiment
more info
PubMed 
regulation of synaptic vesicle exocytosis IDA
Inferred from Direct Assay
more info
PubMed 
response to cocaine IDA
Inferred from Direct Assay
more info
PubMed 
response to drug ISO
Inferred from Sequence Orthology
more info
 
response to ethanol IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to mineralocorticoid IEP
Inferred from Expression Pattern
more info
PubMed 
response to toxic substance ISO
Inferred from Sequence Orthology
more info
 
vasoconstriction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
calyx of Held EXP
Inferred from Experiment
more info
PubMed 
calyx of Held IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
serotonergic synapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
5-hydroxytryptamine receptor 1B
Names
5-HT-1B
5-HT1B serotonin receptor
5-hydroxytryptamine (serotonin ) receptor 1B
5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
serotonin (5-hydroxytryptamine (5HT)) receptor type 1B
serotonin receptor 1B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022225.1NP_071561.1  5-hydroxytryptamine receptor 1B

    See identical proteins and their annotated locations for NP_071561.1

    Status: PROVISIONAL

    Source sequence(s)
    M89954
    UniProtKB/Swiss-Prot
    P28564
    Related
    ENSRNOP00000017411.1, ENSRNOT00000017411.3
    Conserved Domains (2) summary
    pfam00001
    Location:63365
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:63182
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005107.4 Reference Rnor_6.0 Primary Assembly

    Range
    89113984..89130830 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_356450.3 RNA Sequence

Alternate Rn_Celera

Genomic

  1. AC_000076.1 Alternate Rn_Celera

    Range
    82222051..82223211 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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