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Hk2 hexokinase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25059, updated on 9-Dec-2024

Summary

Official Symbol
Hk2provided by RGD
Official Full Name
hexokinase 2provided by RGD
Primary source
RGD:2797
See related
EnsemblRapid:ENSRNOG00000006116 AllianceGenome:RGD:2797
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables ATP binding activity; D-glucose binding activity; and hexokinase activity. Involved in several processes, including carbohydrate phosphorylation; lactation; and response to ischemia. Located in sarcoplasmic reticulum. Biomarker of hypertension and obesity. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Orthologous to human HK2 (hexokinase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Muscle (RPKM 142.4), Heart (RPKM 129.8) and 8 other tissues See more
Orthologs
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Genomic context

See Hk2 in Genome Data Viewer
Location:
4q34
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (116792258..116841275, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (115234509..115283530, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (113559396..113609897, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547728 Neighboring gene uncharacterized LOC120102317 Neighboring gene ribosomal protein S27a, pseudogene 18 Neighboring gene ssemaphorin 4F

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables D-glucose binding IDA
Inferred from Direct Assay
more info
PubMed 
enables D-glucose binding IEA
Inferred from Electronic Annotation
more info
 
enables fructokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables fructokinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables glucokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables glucokinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables glucokinase activity ISO
Inferred from Sequence Orthology
more info
 
enables hexokinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables hexokinase activity IEA
Inferred from Electronic Annotation
more info
 
enables hexokinase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic mitochondrial changes ISO
Inferred from Sequence Orthology
more info
 
involved_in carbohydrate phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in carbohydrate phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within carbohydrate phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of protein localization to mitochondrion ISO
Inferred from Sequence Orthology
more info
 
involved_in fructose 6-phosphate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glucose 6-phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in glucose 6-phosphate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glucose 6-phosphate metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in glucose catabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in glucose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within glucose metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
 
involved_in hexose metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular glucose homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in lactation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in maintenance of protein location in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of mitochondrial membrane permeability ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of type 2 mitophagy ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of D-glucose import ISO
Inferred from Sequence Orthology
more info
 
involved_in response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to ischemia IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in centrosome IEA
Inferred from Electronic Annotation
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial outer membrane TAS
Traceable Author Statement
more info
PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in sarcoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
hexokinase-2
Names
HK II
hexokinase type II
hexokinase-B
type II hexokinase
NP_036867.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012735.2NP_036867.1  hexokinase-2

    See identical proteins and their annotated locations for NP_036867.1

    Status: PROVISIONAL

    Source sequence(s)
    M68971
    UniProtKB/Swiss-Prot
    P27881, Q9QWR1
    UniProtKB/TrEMBL
    A6IAI1, O54892
    Related
    ENSRNOP00000008813.1, ENSRNOT00000008813.5
    Conserved Domains (3) summary
    PTZ00107
    Location:12460
    PTZ00107; hexokinase; Provisional
    pfam00349
    Location:471667
    Hexokinase_1
    pfam03727
    Location:673907
    Hexokinase_2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    116792258..116841275 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)