Format

Send to:

Choose Destination

Hk1 hexokinase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25058, updated on 12-Mar-2017
Official Symbol
Hk1provided by RGD
Official Full Name
hexokinase 1provided by RGD
Primary source
RGD:2796
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
HKI; HEXOKIN
Summary
a ATP:D-hexose 6-phosphotransferase involved in the phosphorylation of glucose to produce glucose-6-phosphate [RGD, Feb 2006]
Annotation information
Annotation category: partial on reference assembly
Orthologs
Location:
20q11
Exon count:
16
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (31911460..31979780, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 20 NC_005119.3 (33703472..33770598, complement)

Chromosome 20 - NC_005119.4Genomic Context describing neighboring genes Neighboring gene similar to family with sequence similarity 96, member A Neighboring gene tachykinin receptor 2 Neighboring gene hexokinase 1-like Neighboring gene Suv3 like RNA helicase

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

  • Homologs of the Hk1 gene: The Hk1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, chicken, zebrafish, fruit fly, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
  • Orthologs from Annotation Pipeline: 158 organisms have orthologs with human gene Hk1
  • Map Viewer (Human, Mouse)

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IC
Inferred by Curator
more info
PubMed 
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase activity IC
Inferred by Curator
more info
PubMed 
fructokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
glucokinase activity IDA
Inferred from Direct Assay
more info
PubMed 
glucokinase activity IEA
Inferred from Electronic Annotation
more info
 
glucokinase activity ISO
Inferred from Sequence Orthology
more info
 
glucose binding IDA
Inferred from Direct Assay
more info
PubMed 
glucose binding IEA
Inferred from Electronic Annotation
more info
 
hexokinase activity IDA
Inferred from Direct Assay
more info
PubMed 
hexokinase activity ISO
Inferred from Sequence Orthology
more info
 
mannokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding IDA
Inferred from Direct Assay
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
carbohydrate phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
carbohydrate phosphorylation IEA
Inferred from Electronic Annotation
more info
 
cellular glucose homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
cellular glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 
establishment of protein localization to mitochondrion IEA
Inferred from Electronic Annotation
more info
 
establishment of protein localization to mitochondrion ISO
Inferred from Sequence Orthology
more info
 
glucose 6-phosphate metabolic process IEA
Inferred from Electronic Annotation
more info
 
glycolytic process IDA
Inferred from Direct Assay
more info
PubMed 
glycolytic process IEA
Inferred from Electronic Annotation
more info
 
hexose metabolic process IEA
Inferred from Electronic Annotation
more info
 
maintenance of protein location in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
maintenance of protein location in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-threonine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of anion channel activity IDA
Inferred from Direct Assay
more info
PubMed 
response to brassinosteroid IEP
Inferred from Expression Pattern
more info
PubMed 
response to ischemia IDA
Inferred from Direct Assay
more info
PubMed 
response to ketamine IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
caveola IDA
Inferred from Direct Assay
more info
PubMed 
cilium ISO
Inferred from Sequence Orthology
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
membrane raft IEA
Inferred from Electronic Annotation
more info
 
membrane raft ISO
Inferred from Sequence Orthology
more info
 
mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
protein complex IDA
Inferred from Direct Assay
more info
PubMed 
sperm principal piece IEA
Inferred from Electronic Annotation
more info
 
sperm principal piece ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
hexokinase-1
Names
HK I
brain form hexokinase
hexokinase type I
NP_036866.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012734.1NP_036866.1  hexokinase-1

    See identical proteins and their annotated locations for NP_036866.1

    Status: PROVISIONAL

    Source sequence(s)
    J04526
    UniProtKB/Swiss-Prot
    P05708
    Conserved Domains (3) summary
    PTZ00107
    Location:462907
    PTZ00107; hexokinase; Provisional
    pfam00349
    Location:469667
    Hexokinase_1; Hexokinase
    pfam03727
    Location:673907
    Hexokinase_2; Hexokinase

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005119.4 Reference Rnor_6.0 Primary Assembly

    Range
    31911460..31979780 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000088.1 Alternate Rn_Celera

    Range
    31652769..31721279 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center