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Rbp1 retinol binding protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25056, updated on 5-Feb-2026
Official Symbol
Rbp1provided by RGD
Official Full Name
retinol binding protein 1provided by RGD
Primary source
RGD:3543
See related
AllianceGenome:RGD:3543
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables retinol binding activity. Involved in response to benzoic acid; response to retinoic acid; and retinoid metabolic process. Located in cell body. Human ortholog(s) of this gene implicated in multiple myeloma. Orthologous to human RBP1 (retinol binding protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Liver (RPKM 917.6), Kidney (RPKM 594.2) and 8 other tissues See more
Orthologs
all
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See Rbp1 in Genome Data Viewer
Location:
8q31
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (107904589..107926109)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (99025218..99046740)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (106449321..106470842)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene calsyntenin 2 Neighboring gene U6 spliceosomal RNA Neighboring gene nicotinamide nucleotide adenylyltransferase 3 Neighboring gene NME/NM23 nucleoside diphosphate kinase 2, pseudogene 8 Neighboring gene retinol binding protein 2

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Comparison of the tissue-specific expression and developmental regulation of two closely linked rodent genes encoding cytosolic retinol-binding proteins. Levin MS, et al. J Biol Chem, 1987 May 25. PMID 3584109
  2. [The role of cellular retinol-binding protein-1 on pulmonary structural remodeling after rat myocardial infarction]. Li L, et al. Zhonghua Yi Xue Za Zhi, 2012 Jul 10. PMID 22944241
  3. The primary structure of rat liver cellular retinol-binding protein. Sundelin J, et al. J Biol Chem, 1985 May 25. PMID 4039728
  4. Cellular retinol-binding protein. Quantitation and distribution. Eriksson U, et al. J Biol Chem, 1984 Nov 10. PMID 6541654
  5. Mass spectrometry techniques for detection of ligand-dependent changes in the conformational flexibility of cellular retinol-binding protein type I localized by hydrogen/deuterium exchange. Careri M, et al. Rapid Commun Mass Spectrom, 2006. PMID 16755609

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Retinal proteomic evaluation of rats following streptozotocininjection using shotgun proteomics.
    Title: Retinal proteomic evaluation of rats following streptozotocin‑injection using shotgun proteomics.
  2. CRBP1 contributes to pulmonary structural remodeling after myocardial infarction.
    Title: [The role of cellular retinol-binding protein-1 on pulmonary structural remodeling after rat myocardial infarction].
  3. a potential role of CRBP1 in the regulation of beta-catenin turnover which can greatly affect the process of osteogenesis and adipogenesis of mesenchymal stem cells
    Title: Cellular retinol-binding protein 1 (CRBP-1) regulates osteogenenesis and adipogenesis of mesenchymal stem cells through inhibiting RXRα-induced β-catenin degradation.
  4. As the convoluted proximal tubular epithelial cells dedifferentiate during fibrosis, CRBP-I expression decreases in adriamycin-induced fibrotic rat kidney.
    Title: CRBP-I in the renal tubulointerstitial compartment of healthy rats and rats with renal fibrosis.
  5. analysis of conformational flexibility of rat cellular retinol-binding protein I (CRBP I) and cellular retinol-binding protein II (CRBP II)
    Title: Two homologous rat cellular retinol-binding proteins differ in local conformational flexibility.
  6. Structure and backbone dynamics of Apo- and holo-cellular retinol-binding protein in solution
    Title: Structure and backbone dynamics of Apo- and holo-cellular retinol-binding protein in solution.
  7. CRBP1 has a role in vitamin A metabolism and its absence may play a role in ovarian cancer oncogenesis
    Title: Loss of cellular retinol-binding protein 1 gene expression in microdissected human ovarian cancer.
  8. differences in conformational flexibility between the ligand-free and ligand-bound forms of cellular retinol-binding protein type I
    Title: Mass spectrometry techniques for detection of ligand-dependent changes in the conformational flexibility of cellular retinol-binding protein type I localized by hydrogen/deuterium exchange.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables all-trans-retinol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables all-trans-retinol binding ISO
Inferred from Sequence Orthology
more info
  
enables all-trans-retinol binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables fatty acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables retinal binding IEA
Inferred from Electronic Annotation
more info
  
enables retinol binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables retinol binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fatty acid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lipid storage ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of granulocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in response to benzoic acid IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to retinoic acid HEP PubMed 
involved_in response to retinoic acid IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to vitamin A ISO
Inferred from Sequence Orthology
more info
  
involved_in retinoic acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within retinoic acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in retinoid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in retinol metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within retinol metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in vitamin A metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in vitamin A metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in vitamin A metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in lipid droplet IEA
Inferred from Electronic Annotation
more info
  
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
  
located_in lipid droplet ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
retinol-binding protein 1
Names
CRBP
CRBP-I
cellular retinol-binding protein I
retinol binding protein 1, cellular
NP_036865.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012733.5 → NP_036865.1  retinol-binding protein 1

    See identical proteins and their annotated locations for NP_036865.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    P02696
    Conserved Domains (1) summary
    cd19462
    Location:4 → 134
    CRBP1; cellular retinol-binding protein 1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    107904589..107926109
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P02696.2 GenPept UniProtKB/Swiss-Prot:P02696

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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