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Camk4 calcium/calmodulin-dependent protein kinase IV [ Rattus norvegicus (Norway rat) ]

Gene ID: 25050, updated on 2-Nov-2024

Summary

Official Symbol
Camk4provided by RGD
Official Full Name
calcium/calmodulin-dependent protein kinase IVprovided by RGD
Primary source
RGD:2264
See related
EnsemblRapid:ENSRNOG00000020478 AllianceGenome:RGD:2264
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ccdpk; RATCCDPK
Summary
Enables calcium/calmodulin-dependent protein kinase activity. Involved in protein phosphorylation. Is active in glutamatergic synapse and postsynapse. Biomarker of alcohol use disorder and withdrawal disorder. Human ortholog(s) of this gene implicated in cocaine dependence. Orthologous to human CAMK4 (calcium/calmodulin dependent protein kinase IV). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 286.0), Brain (RPKM 259.1) and 2 other tissues See more
Orthologs
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Genomic context

See Camk4 in Genome Data Viewer
Location:
18p12
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (24857152..25076054)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (24582988..24811918)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (25746878..25975962)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene WD repeat domain 36 Neighboring gene uncharacterized LOC134482926 Neighboring gene uncharacterized LOC120098266 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134482925 Neighboring gene StAR-related lipid transfer domain containing 4 Neighboring gene neuronal regeneration related protein

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium/calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium/calmodulin-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium/calmodulin-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables calcium/calmodulin-dependent protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in long-term memory IEA
Inferred from Electronic Annotation
more info
 
involved_in long-term memory ISO
Inferred from Sequence Orthology
more info
 
involved_in long-term memory ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in myeloid dendritic cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in myeloid dendritic cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in myeloid dendritic cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within neuron-neuron synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within nucleocytoplasmic transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT involved_in positive regulation of myeloid dendritic cell cytokine production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of protein export from nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in postsynapse to nucleus signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in postsynaptic modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within signal transduction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in fibrillar center IEA
Inferred from Electronic Annotation
more info
 
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
calcium/calmodulin-dependent protein kinase type IV
Names
CAM kinase-GR
Calmodulin-dependent protein kinase IV
caMK IV
calspermin
NP_036859.2
XP_006254585.3
XP_038952502.1
XP_063133166.1
XP_063133167.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012727.3NP_036859.2  calcium/calmodulin-dependent protein kinase type IV

    See identical proteins and their annotated locations for NP_036859.2

    Status: PROVISIONAL

    Source sequence(s)
    BC128706
    UniProtKB/Swiss-Prot
    A1A5L5, P13234, Q63892
    UniProtKB/TrEMBL
    A6J2R5
    Related
    ENSRNOP00000027771.4, ENSRNOT00000027771.6
    Conserved Domains (1) summary
    cd14085
    Location:38331
    STKc_CaMKIV; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type IV

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    24857152..25076054
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006254523.5XP_006254585.3  calcium/calmodulin-dependent protein kinase type IV isoform X2

    UniProtKB/TrEMBL
    A0A8L2UQP4, A6J2R2
  2. XM_063277096.1XP_063133166.1  calcium/calmodulin-dependent protein kinase type IV isoform X1

    UniProtKB/TrEMBL
    A6J2R3
    Related
    ENSRNOP00000072926.3, ENSRNOT00000078822.3
  3. XM_063277097.1XP_063133167.1  calcium/calmodulin-dependent protein kinase type IV isoform X4

  4. XM_039096574.2XP_038952502.1  calcium/calmodulin-dependent protein kinase type IV isoform X3

    Conserved Domains (1) summary
    cl21453
    Location:43226
    PKc_like; Protein Kinases, catalytic domain