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P2rx6 purinergic receptor P2X 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25041, updated on 12-Aug-2018

Summary

Official Symbol
P2rx6provided by RGD
Official Full Name
purinergic receptor P2X 6provided by RGD
Primary source
RGD:3243
See related
Ensembl:ENSRNOG00000001873
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
P2x6; P2rxl1; Rnap2x6
Summary
acts as an ATP-gated ion channel [RGD, Feb 2006]
Expression
Biased expression in Muscle (RPKM 54.0), Lung (RPKM 24.4) and 4 other tissues See more
Orthologs

Genomic context

See P2rx6 in Genome Data Viewer
Location:
11q23
Exon count:
13
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (87434929..87445221)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 11 NC_005110.3 (90485985..90496515)

Chromosome 11 - NC_005110.4Genomic Context describing neighboring genes Neighboring gene THAP domain containing 7 Neighboring gene translation machinery-associated protein 16 pseudogene Neighboring gene leucine rich repeat containing 74B Neighboring gene solute carrier family 7, member 4 Neighboring gene uncharacterized LOC108352365

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATP-gated ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellularly ATP-gated cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellularly ATP-gated cation channel activity IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
purinergic nucleotide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
cation transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
 
ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein heterooligomerization IDA
Inferred from Direct Assay
more info
PubMed 
protein homooligomerization IEA
Inferred from Electronic Annotation
more info
 
protein homooligomerization ISO
Inferred from Sequence Orthology
more info
 
purinergic nucleotide receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
response to ATP IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell junction IEA
Inferred from Electronic Annotation
more info
 
cell junction ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of nuclear inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of postsynaptic specialization membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
parallel fiber to Purkinje cell synapse IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
P2X purinoceptor 6
Names
ATP receptor
P2X6 receptor
P2XM
purinergic receptor P2X, ligand-gated ion channel, 6
purinergic receptor P2X-like 1 orphan receptor
purinergic receptor P2X6

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012721.2NP_036853.2  P2X purinoceptor 6

    See identical proteins and their annotated locations for NP_036853.2

    Status: VALIDATED

    Source sequence(s)
    CO554543, X92070, X97376
    UniProtKB/Swiss-Prot
    P51579
    Related
    ENSRNOP00000002558.5, ENSRNOT00000002558.6
    Conserved Domains (1) summary
    TIGR00863
    Location:22376
    P2X; cation transporter protein

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005110.4 Reference Rnor_6.0 Primary Assembly

    Range
    87434929..87445221
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017597882.1XP_017453371.1  P2X purinoceptor 6 isoform X1

  2. XM_017597883.1XP_017453372.1  P2X purinoceptor 6 isoform X2

Alternate Rn_Celera

Genomic

  1. AC_000079.1 Alternate Rn_Celera

    Range
    82208493..82218517 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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