Insr insulin receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Insrprovided by RGD
Official Full Name: insulin receptorprovided by RGD
Primary source: RGD:2917
See related: Ensembl:ENSRNOG00000029986 AllianceGenome:RGD:2917
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables several functions, including enzyme binding activity; insulin binding activity; and insulin receptor activity. Involved in several processes, including neuron projection organization; protein phosphorylation; and regulation of primary metabolic process. Located in several cellular components, including dendrite membrane; external side of plasma membrane; and neuronal cell body membrane. Used to study chronic kidney disease; diabetic neuropathy; liver disease (multiple); and type 2 diabetes mellitus. Biomarker of several diseases, including Alzheimer's disease; diabetes mellitus (multiple); hepatic encephalopathy; liver disease (multiple); and short bowel syndrome. Human ortholog(s) of this gene implicated in Donohue syndrome; glucose metabolism disease (multiple); and reproductive organ cancer (multiple). Orthologous to human INSR (insulin receptor). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in Kidney (RPKM 142.4), Adrenal (RPKM 139.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12p12

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (5991135..6129275, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (1193193..1330976, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (1682527..1816414, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Blockade of endogenous insulin receptor signaling in the nucleus tractus solitarius potentiates exercise pressor reflex function in healthy male rats.
Title: Blockade of endogenous insulin receptor signaling in the nucleus tractus solitarius potentiates exercise pressor reflex function in healthy male rats.
The Postnatal Offspring of Finasteride-Treated Male Rats Shows Hyperglycaemia, Elevated Hepatic Glycogen Storage and Altered GLUT2, IR, and AR Expression in the Liver.
Title: The Postnatal Offspring of Finasteride-Treated Male Rats Shows Hyperglycaemia, Elevated Hepatic Glycogen Storage and Altered GLUT2, IR, and AR Expression in the Liver.
Insulin-like growth factor-2 regulates basal retinal insulin receptor activity.
Title: Insulin-like growth factor-2 regulates basal retinal insulin receptor activity.
Rbfox2 mediates exon 11 inclusion in insulin receptor pre-mRNA splicing in hepatoma cells.
Title: Rbfox2 mediates exon 11 inclusion in insulin receptor pre-mRNA splicing in hepatoma cells.
Study found that activation of AT2R decrease insulin receptor expression and function in renal proximal tubule (RPT) cells from Wistar-Kyoto rats, whereas this inhibitory effect disturbed in RPT cells from spontaneously hypertensive rats. Results suggest that interaction between AT2R and insulin receptor may play an important role in the abnormal regulation of sodium excretion and consequently implicated in hypertension.
Title: Angiotensin II type 2 receptor inhibits expression and function of insulin receptor in rat renal proximal tubule cells.
Our data indicates that activation of IGF-1R and/or the IR autocrine loops resulting in beta-cell protection and function, involve mechanisms independent to the enhanced metabolic effects resulting from sustained GLP-1R activation.
Title: Insulin and IGF-1 receptor autocrine loops are not required for Exendin-4 induced changes to pancreatic β-cell bioenergetic parameters and metabolism in BRIN-BD11 cells.
a preponderance of InsR-immunoreactivity among primary sensory neurons, which innervate visceral targets, is reported.
Title: The insulin receptor is differentially expressed in somatic and visceral primary sensory neurons.
Findings indicate functional interactions of the nociceptive ion channel transient receptor potential vanilloid type 1 receptor (TRPV1) and the insulin receptor (InsR).
Title: The Insulin Receptor Is Colocalized With the TRPV1 Nociceptive Ion Channel and Neuropeptides in Pancreatic Spinal and Vagal Primary Sensory Neurons.
A single low streptozotocin (STZ) dose into the lateral ventricles of the adult rats induces wide-spread neuroinflammation in the cortical, hippocampal and hypothalamic regions and more regional-specific alterations in GLUT2 and insulin receptor (IR) protein expression, observed as early as 1 h after the treatment. GLUT2 and IR expression was altered in areas close to the site of STZ release and downstream the CSF flow.
Title: Rat brain glucose transporter-2, insulin receptor and glial expression are acute targets of intracerebroventricular streptozotocin: risk factors for sporadic Alzheimer's disease?
The developed combined model could describe data not used for training the model and was used to generate predictions of the relative contributions of the pathways from IR to translocation of GLUT4.
Title: A systems biology analysis connects insulin receptor signaling with glucose transporter translocation in rat adipocytes.

Submit: New GeneRIF Correction See all GeneRIFs (74)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D12Wox26 (e-PCR)
- UniSTS:518669

d12rat56 (e-PCR)
- UniSTS:120846

D12Wox28 (e-PCR)
- UniSTS:518689

AU048528 (e-PCR)
- UniSTS:144978

BF390301 (e-PCR)
- UniSTS:249433

PMC152262P1 (e-PCR)
- UniSTS:271209

Insr (e-PCR), detects polymorphism
- UniSTS:530845

D12Arb12 (e-PCR)
- UniSTS:240632

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables PTB domain binding	ISO Inferred from Sequence Orthology more info
enables amyloid-beta binding	ISO Inferred from Sequence Orthology more info
enables cargo receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables insulin binding	IDA Inferred from Direct Assay more info	PubMed
enables insulin binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables insulin binding	ISO Inferred from Sequence Orthology more info
enables insulin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables insulin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables insulin receptor activity	IEA Inferred from Electronic Annotation more info
enables insulin receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables insulin receptor activity	ISO Inferred from Sequence Orthology more info
enables insulin receptor substrate binding	IBA Inferred from Biological aspect of Ancestor more info
enables insulin receptor substrate binding	IEA Inferred from Electronic Annotation more info
enables insulin receptor substrate binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables insulin receptor substrate binding	ISO Inferred from Sequence Orthology more info
enables insulin-like growth factor I binding	ISO Inferred from Sequence Orthology more info
enables insulin-like growth factor II binding	ISO Inferred from Sequence Orthology more info
enables insulin-like growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables lipoic acid binding	IPI Inferred from Physical Interaction more info	PubMed
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol 3-kinase binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol 3-kinase binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein kinase activator activity	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables structural molecule activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adrenal gland development	ISO Inferred from Sequence Orthology more info
involved_in amyloid-beta clearance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in animal organ development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within animal organ morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to zinc ion starvation	IEP Inferred from Expression Pattern more info	PubMed
involved_in cerebellum development	IEP Inferred from Expression Pattern more info	PubMed
involved_in dendritic spine maintenance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryonic liver development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within epidermis development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within exocrine pancreas development	ISO Inferred from Sequence Orthology more info
involved_in fat cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in glucose homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in heart morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in hippocampus development	IEP Inferred from Expression Pattern more info	PubMed
involved_in insulin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in insulin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in insulin receptor signaling pathway	IEP Inferred from Expression Pattern more info	PubMed
involved_in insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in liver development	IEP Inferred from Expression Pattern more info	PubMed
involved_in liver regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in male gonad development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within male sex determination	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of glycogen biosynthetic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in neuron projection maintenance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of D-glucose import	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cellular component organization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of developmental growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of glycogen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glycogen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glycolytic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glycoprotein biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of macromolecule biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of meiotic cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of mitotic nuclear division	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic nuclear division	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein-containing complex disassembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of respiratory burst	ISO Inferred from Sequence Orthology more info
acts_upstream_of_positive_effect receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in receptor-mediated endocytosis	IEA Inferred from Electronic Annotation more info
involved_in receptor-mediated endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of embryonic development	ISO Inferred from Sequence Orthology more info
involved_in regulation of female gonad development	ISO Inferred from Sequence Orthology more info
involved_in regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in regulation of gluconeogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of glucose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of glycogen biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of hydrogen peroxide metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of multicellular organismal process	IEA Inferred from Electronic Annotation more info
involved_in response to activity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to food	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucocorticoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucose	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to insulin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to manganese ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient levels	IDA Inferred from Direct Assay more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to resveratrol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to starvation	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to testosterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to tumor necrosis factor	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to vanadate(3-)	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to vitamin D	IEP Inferred from Expression Pattern more info	PubMed
involved_in symbiont entry into host cell	ISO Inferred from Sequence Orthology more info
involved_in system development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in caveola	ISO Inferred from Sequence Orthology more info
colocalizes_with cell body	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
part_of insulin receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of insulin receptor complex	ISO Inferred from Sequence Orthology more info
located_in late endosome	IEA Inferred from Electronic Annotation more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
colocalizes_with neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nuclear lumen	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info
located_in yolk	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: insulin receptor

Names: IR; insulin receptor preproprotein

NP_058767.2

EC 2.7.10.1

XP_038945024.1

EC 2.7.10.1

XP_038945025.1

EC 2.7.10.1

XP_063127138.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017071.2 → NP_058767.2 insulin receptor preproprotein

See identical proteins and their annotated locations for NP_058767.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

UniProtKB/TrEMBL

A0A8J8Y5N6, A0A9K3Y780, F1LN53, F1LPL6, T2CB11

Related

ENSRNOP00000060141.4, ENSRNOT00000067448.5

Conserved Domains (6) summary

cd05061
Location:1018 → 1305

PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor

cd00063
Location:869 → 946

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00064
Location:234 → 281

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

pfam00757
Location:179 → 337

Furin-like; Furin-like cysteine rich region

pfam01030
Location:359 → 472

Recep_L_domain; Receptor L domain

pfam07714
Location:1025 → 1292

Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

5991135..6129275 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063271068.1 → XP_063127138.1 insulin receptor isoform X3

UniProtKB/TrEMBL

A0A8J8Y5N6
XM_039089097.2 → XP_038945025.1 insulin receptor isoform X2

UniProtKB/TrEMBL

A0A8I5ZMZ8, A0A8J8Y5N6

Conserved Domains (5) summary

cd05061
Location:1006 → 1293

PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor

cd00063
Location:857 → 934

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00757
Location:179 → 337

Furin-like; Furin-like cysteine rich region

pfam01030
Location:359 → 472

Recep_L_domain; Receptor L domain

pfam17870
Location:930 → 977

Insulin_TMD; Insulin receptor trans-membrane segment
XM_039089096.2 → XP_038945024.1 insulin receptor isoform X1

UniProtKB/TrEMBL

A0A8J8Y5N6

Conserved Domains (5) summary

cd05061
Location:1017 → 1304

PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor

cd00063
Location:869 → 946

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00757
Location:179 → 337

Furin-like; Furin-like cysteine rich region

pfam01030
Location:359 → 472

Recep_L_domain; Receptor L domain

pfam17870
Location:942 → 988

Insulin_TMD; Insulin receptor trans-membrane segment