Cd8b CD8 subunit beta [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cd8bprovided by RGD
Official Full Name: CD8 subunit betaprovided by RGD
Primary source: RGD:2317
See related: Ensembl:ENSRNOG00000007129 AllianceGenome:RGD:2317
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cd8b1
Summary: Predicted to enable MHC class I protein binding activity and coreceptor activity. Predicted to be involved in T cell activation and T cell receptor signaling pathway. Predicted to be located in external side of plasma membrane. Predicted to be part of receptor complex. Predicted to be active in cell surface. Orthologous to several human genes including CD8B (CD8 subunit beta). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Restricted expression toward (RPKM 999.3) See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 4q32

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (104870911..104886838)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (103312596..103328523)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (99185960..99201887)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CD8 positive T suppressor cells protect allogenic recipients from acute rejection in rats liver transplantation.
Title: The protective effect of CD8+CD28- T suppressor cells on the acute rejection responses in rat liver transplantation.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables MHC class I protein binding	IEA Inferred from Electronic Annotation more info
enables coreceptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in T cell activation	ISO Inferred from Sequence Orthology more info
involved_in T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in immune system process	IEA Inferred from Electronic Annotation more info
involved_in regulation of immune response	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: T-cell surface glycoprotein CD8 beta chain

Names: CD8 antigen 37 kDa chain; CD8 antigen beta-chain; CD8b molecule; OX-8 membrane antigen

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031539.2 → NP_113727.2 T-cell surface glycoprotein CD8 beta chain precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

A6IA70, G3V6V7, Q6PCV0

Related

ENSRNOP00000009392.6, ENSRNOT00000009392.9

Conserved Domains (1) summary

cd07700
Location:22 → 134

IgV_CD8_beta; Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain