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Slc6a3 solute carrier family 6 member 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24898, updated on 5-Jan-2023

Summary

Official Symbol
Slc6a3provided by RGD
Official Full Name
solute carrier family 6 member 3provided by RGD
Primary source
RGD:3715
See related
Ensembl:ENSRNOG00000017302 AllianceGenome:RGD:3715
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Dat1
Summary
Enables several functions, including amine binding activity; dopamine:sodium symporter activity; and enzyme binding activity. Involved in several processes, including dopamine transport; response to cAMP; and response to ethanol. Located in neuron projection and plasma membrane. Is active in dopaminergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Biomarker of Parkinsonism; heroin dependence; high grade glioma; hyperprolactinemia; and hypertension. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder; nicotine dependence; and obesity. Orthologous to human SLC6A3 (solute carrier family 6 member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 15.2), Kidney (RPKM 0.8) and 1 other tissue See more
Orthologs
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Genomic context

See Slc6a3 in Genome Data Viewer
Location:
1p11
Exon count:
15
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (29709443..29750413, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (32323011..32363983, complement)

Chromosome 1 - NC_051336.1Genomic Context describing neighboring genes Neighboring gene telomerase reverse transcriptase Neighboring gene CLPTM1-like Neighboring gene lysophosphatidylcholine acyltransferase 1 Neighboring gene uncharacterized LOC120098984

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables amine binding IDA
Inferred from Direct Assay
more info
PubMed 
enables amine binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables dopamine binding ISO
Inferred from Sequence Orthology
more info
 
enables dopamine:sodium symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables dopamine:sodium symporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables dopamine:sodium symporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables dopamine:sodium symporter activity ISO
Inferred from Sequence Orthology
more info
 
enables heterocyclic compound binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables monoamine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables neurotransmitter transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables norepinephrine:sodium symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables norepinephrine:sodium symporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase 2A binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within adenohypophysis development ISO
Inferred from Sequence Orthology
more info
 
involved_in aging IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within dopamine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within dopamine catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in dopamine transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within dopamine transport ISO
Inferred from Sequence Orthology
more info
 
involved_in dopamine transport ISO
Inferred from Sequence Orthology
more info
 
involved_in dopamine uptake ISO
Inferred from Sequence Orthology
more info
 
involved_in dopamine uptake involved in synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in hyaloid vascular plexus regression ISO
Inferred from Sequence Orthology
more info
 
involved_in hyaloid vascular plexus regression ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within lactation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within locomotory behavior ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within monoamine transport ISO
Inferred from Sequence Orthology
more info
 
involved_in neurotransmitter transport ISO
Inferred from Sequence Orthology
more info
 
involved_in neurotransmitter uptake ISO
Inferred from Sequence Orthology
more info
 
involved_in norepinephrine transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in norepinephrine uptake IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of multicellular organism growth ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within prepulse inhibition ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of dopamine metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in response to cAMP IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to cocaine ISO
Inferred from Sequence Orthology
more info
 
involved_in response to ethanol IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to iron ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to nicotine IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within sensory perception of smell ISO
Inferred from Sequence Orthology
more info
 
involved_in sodium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in axon terminus ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
is_active_in dopaminergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
part_of flotillin complex ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
is_active_in neuronal cell body membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
sodium-dependent dopamine transporter
Names
DA transporter
DAT
solute carrier family 6 (neurotransmitter transporter), member 3
solute carrier family 6 (neurotransmitter transporter, dopamine), member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012694.2NP_036826.1  sodium-dependent dopamine transporter

    See identical proteins and their annotated locations for NP_036826.1

    Status: PROVISIONAL

    Source sequence(s)
    M80233
    UniProtKB/Swiss-Prot
    P23977
    Related
    ENSRNOP00000047272.1, ENSRNOT00000040291.2
    Conserved Domains (1) summary
    cd11514
    Location:60613
    SLC6sbd_DAT1; Na(+)- and Cl(-)-dependent dopamine transporter 1; solute-binding domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051336.1 Reference mRatBN7.2 Primary Assembly

    Range
    29709443..29750413 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)