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Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24894, updated on 28-Oct-2021

Summary

Official Symbol
Cyp2a1provided by RGD
Official Full Name
cytochrome P450, family 2, subfamily a, polypeptide 1provided by RGD
Primary source
RGD:2463
See related
EnsemblRapid:ENSRNOG00000020817
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Shdl; RATCYP2A1
Summary
has testosterone 7 alpha-hydroxylase activity; also catalyzes 3,4 epoxidation of coumarin in coumarin metabolism [RGD, Feb 2006]
Expression
Restricted expression toward (RPKM 3458.7) See more
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Genomic context

See Cyp2a1 in Genome Data Viewer
Location:
1q21
Exon count:
9
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (82231611..82244887)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (83711223..83725222)

Chromosome 1 - NC_051336.1Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 2, subfamily g, polypeptide 1 Neighboring gene uncharacterized LOC103691073 Neighboring gene cytochrome P450, family 2, subfamily a, polypeptide 3 Neighboring gene cytochrome P450, family 2, subfamily a, polypeptide 2 Neighboring gene uncharacterized LOC108349422

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in coumarin metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in coumarin metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in epoxygenase P450 pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in organic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in xenobiotic metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cytochrome P450 2A1
Names
CYPIIA1
P450-UT-F
cytochrome P450 IIA1 (hepatic steroid hydroxylase IIA1)
cytochrome P450-UT-F
steroid hormones 7-alpha-hydroxylase
steroid hydroxylase, hepatic
testosterone 7-alpha-hydroxylase
NP_036824.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012692.1NP_036824.1  cytochrome P450 2A1

    See identical proteins and their annotated locations for NP_036824.1

    Status: PROVISIONAL

    Source sequence(s)
    J02669
    UniProtKB/Swiss-Prot
    P11711
    Related
    ENSRNOP00000028237.2, ENSRNOT00000028237.5
    Conserved Domains (1) summary
    pfam00067
    Location:33489
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051336.1 Reference mRatBN7.2 Primary Assembly

    Range
    82231611..82244887
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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