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Abcb4 ATP binding cassette subfamily B member 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24891, updated on 3-Jan-2019

Summary

Official Symbol
Abcb4provided by RGD
Official Full Name
ATP binding cassette subfamily B member 4provided by RGD
Primary source
RGD:620248
See related
Ensembl:ENSRNOG00000008012
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mdr2; Pgy3
Summary
energy-dependent efflux pump; may be involved in changes in bile formation in response to diabetes [RGD, Feb 2006]
Expression
Biased expression in Liver (RPKM 347.0), Spleen (RPKM 133.5) and 4 other tissues See more

Genomic context

See Abcb4 in Genome Data Viewer
Location:
4q12
Exon count:
29
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (22133984..22192687, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 4 NC_005103.3 (22070806..22128781, complement)

Chromosome 4 - NC_005103.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102555922 Neighboring gene carnitine O-octanoyltransferase Neighboring gene uncharacterized protein C11orf98 homolog pseudogene Neighboring gene uncharacterized LOC103692045 Neighboring gene ATP-binding cassette, subfamily B (MDR/TAP), member 1B

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • ABC transporters, organism-specific biosystem (from KEGG)
    ABC transporters, organism-specific biosystemThe ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of ...
  • ABC transporters, conserved biosystem (from KEGG)
    ABC transporters, conserved biosystemThe ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of ...
  • ABC-family proteins mediated transport, organism-specific biosystem (from REACTOME)
    ABC-family proteins mediated transport, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Bile secretion, organism-specific biosystem (from KEGG)
    Bile secretion, organism-specific biosystemBile is a vital secretion, essential for digestion and absorption of fats and fat-soluble vitamins in the small intestine. Moreover, bile is an important route of elimination for excess cholesterol a...
  • Bile secretion, conserved biosystem (from KEGG)
    Bile secretion, conserved biosystemBile is a vital secretion, essential for digestion and absorption of fats and fat-soluble vitamins in the small intestine. Moreover, bile is an important route of elimination for excess cholesterol a...
  • Nuclear receptors in lipid metabolism and toxicity, organism-specific biosystem (from WikiPathways)
    Nuclear receptors in lipid metabolism and toxicity, organism-specific biosystemNuclear receptors are transcription factors that are activated upon binding to its ligands. Initially, they had been classified as classic endocrine nuclear hormone receptors and orphan receptors. Ho...
  • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
    Transmembrane transport of small molecules, organism-specific biosystemcomputationally inferred pathway (not manually curated)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase activity, coupled to transmembrane movement of substances IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATPase activity, coupled to transmembrane movement of substances IEA
Inferred from Electronic Annotation
more info
 
ATPase activity, coupled to transmembrane movement of substances ISO
Inferred from Sequence Orthology
more info
 
ATPase activity, coupled to transmembrane movement of substances ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT ceramide-translocating ATPase activity ISO
Inferred from Sequence Orthology
more info
 
phosphatidylcholine transporter activity ISO
Inferred from Sequence Orthology
more info
 
phosphatidylcholine transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphatidylcholine-translocating ATPase activity IEA
Inferred from Electronic Annotation
more info
 
phosphatidylcholine-translocating ATPase activity ISO
Inferred from Sequence Orthology
more info
 
phosphatidylcholine-translocating ATPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
bile acid secretion IEA
Inferred from Electronic Annotation
more info
 
bile acid secretion ISO
Inferred from Sequence Orthology
more info
 
bile acid secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to bile acid IEA
Inferred from Electronic Annotation
more info
 
cellular response to bile acid ISO
Inferred from Sequence Orthology
more info
 
cellular response to bile acid ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT ceramide translocation ISO
Inferred from Sequence Orthology
more info
 
NOT drug transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
lipid homeostasis IEA
Inferred from Electronic Annotation
more info
 
lipid homeostasis ISO
Inferred from Sequence Orthology
more info
 
lipid homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
phospholipid translocation IEA
Inferred from Electronic Annotation
more info
 
phospholipid translocation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cholesterol transport IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cholesterol transport ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cholesterol transport ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of phospholipid translocation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of phospholipid translocation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phospholipid translocation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of phospholipid transport ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phospholipid transport ISS
Inferred from Sequence or Structural Similarity
more info
 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to fenofibrate IEA
Inferred from Electronic Annotation
more info
 
response to fenofibrate ISO
Inferred from Sequence Orthology
more info
 
response to fenofibrate ISS
Inferred from Sequence or Structural Similarity
more info
 
response to glucocorticoid IEP
Inferred from Expression Pattern
more info
PubMed 
transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi membrane IDA
Inferred from Direct Assay
more info
PubMed 
actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
clathrin-coated vesicle IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
focal adhesion IEA
Inferred from Electronic Annotation
more info
 
focal adhesion ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intercellular canaliculus IEA
Inferred from Electronic Annotation
more info
 
intercellular canaliculus ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
membrane raft IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
phosphatidylcholine translocator ABCB4
Names
ATP-binding cassette sub-family B (MDR/TAP) member 4 (P-glycoprotein 3/ multidrug resistance 2)
ATP-binding cassette sub-family B member 4
ATP-binding cassette, sub-family B (MDR/TAP), member 4 (P-glycoprotein 3/ multidrug resistance 2)
ATP-binding cassette, subfamily B (MDR/TAP), member 4
P-glycoprotein 2
P-glycoprotein 3
P-glycoprotein 3/ multidrug resistance 2
multidrug resistance protein 2
multidrug resistance protein 3
NP_036822.1
XP_006236061.1
XP_006236062.1
XP_008760919.1
XP_017447963.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012690.2NP_036822.1  phosphatidylcholine translocator ABCB4

    See identical proteins and their annotated locations for NP_036822.1

    Status: PROVISIONAL

    Source sequence(s)
    L15079
    UniProtKB/Swiss-Prot
    Q08201
    Related
    ENSRNOP00000042556.1, ENSRNOT00000043822.1
    Conserved Domains (3) summary
    cd03249
    Location:392628
    ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
    PTZ00265
    Location:291271
    PTZ00265; multidrug resistance protein (mdr1); Provisional
    pfam00664
    Location:58342
    ABC_membrane; ABC transporter transmembrane region

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005103.4 Reference Rnor_6.0 Primary Assembly

    Range
    22133984..22192687 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017592474.1XP_017447963.1  phosphatidylcholine translocator ABCB4 isoform X2

  2. XM_008762697.2XP_008760919.1  phosphatidylcholine translocator ABCB4 isoform X1

    Conserved Domains (3) summary
    cd03249
    Location:392628
    ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
    PTZ00265
    Location:291236
    PTZ00265; multidrug resistance protein (mdr1); Provisional
    pfam00664
    Location:58342
    ABC_membrane; ABC transporter transmembrane region
  3. XM_006236000.2XP_006236062.1  phosphatidylcholine translocator ABCB4 isoform X4

    Conserved Domains (4) summary
    cd03249
    Location:234470
    ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
    COG1126
    Location:233459
    GlnQ; ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]
    COG1132
    Location:5501116
    MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]
    pfam00664
    Location:556826
    ABC_membrane; ABC transporter transmembrane region
  4. XM_006235999.2XP_006236061.1  phosphatidylcholine translocator ABCB4 isoform X3

    Conserved Domains (3) summary
    cd03249
    Location:325561
    ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
    PTZ00265
    Location:761204
    PTZ00265; multidrug resistance protein (mdr1); Provisional
    pfam00664
    Location:17275
    ABC_membrane; ABC transporter transmembrane region

Alternate Rn_Celera

Genomic

  1. AC_000072.1 Alternate Rn_Celera

    Range
    20645103..20702285 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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