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Esr1 estrogen receptor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24890, updated on 10-Oct-2024

Summary

Official Symbol
Esr1provided by RGD
Official Full Name
estrogen receptor 1provided by RGD
Primary source
RGD:2581
See related
EnsemblRapid:ENSRNOG00000019358 AllianceGenome:RGD:2581
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Esr; ER-alpha; RNESTROR
Summary
Enables several functions, including phosphatidylinositol 3-kinase regulatory subunit binding activity; promoter-specific chromatin binding activity; and transcription coactivator binding activity. Involved in several processes, including cellular response to lipid; regulation of neuron death; and reproductive structure development. Located in several cellular components, including T-tubule; perikaryon; and perinuclear region of cytoplasm. Part of protein-containing complex. Used to study several diseases, including Parkinsonism; infertility; obesity; pleurisy; and prostate disease (multiple). Biomarker of cryptorchidism; osteoporosis; and ovarian cancer. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); bone disease (multiple); breast cancer (multiple); type 2 diabetes mellitus; and vitiligo. Orthologous to human ESR1 (estrogen receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Uterus (RPKM 235.5), Kidney (RPKM 77.3) and 7 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Esr1 in Genome Data Viewer
Location:
1q11
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (43511685..43904454)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (41106335..41499104)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (41192029..41594799)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482620 Neighboring gene acidic residue methyltransferase 1 Neighboring gene coiled-coil domain containing 170 Neighboring gene uncharacterized LOC134482628 Neighboring gene small nucleolar RNA SNORD88 Neighboring gene uncharacterized LOC134482627 Neighboring gene spectrin repeat containing nuclear envelope protein 1 Neighboring gene uncharacterized LOC134482626

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 14-3-3 protein binding IEA
Inferred from Electronic Annotation
more info
 
enables 14-3-3 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables ATPase binding IEA
Inferred from Electronic Annotation
more info
 
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables G protein-coupled estrogen receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables TBP-class protein binding IEA
Inferred from Electronic Annotation
more info
 
enables TBP-class protein binding ISO
Inferred from Sequence Orthology
more info
 
enables TFIIB-class transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
enables TFIIB-class transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables beta-catenin binding IEA
Inferred from Electronic Annotation
more info
 
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
 
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables estrogen response element binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables estrogen response element binding IEA
Inferred from Electronic Annotation
more info
 
enables estrogen response element binding ISO
Inferred from Sequence Orthology
more info
 
enables hormone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables hormone binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear estrogen receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables nuclear estrogen receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables nuclear estrogen receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclear estrogen receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nuclear receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables nuclear steroid receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylinositol 3-kinase regulatory subunit binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables promoter-specific chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables steroid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables steroid binding IEA
Inferred from Electronic Annotation
more info
 
enables transcription coactivator binding IEA
Inferred from Electronic Annotation
more info
 
enables transcription coactivator binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coactivator binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription coregulator binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription corepressor binding IEA
Inferred from Electronic Annotation
more info
 
enables transcription corepressor binding ISO
Inferred from Sequence Orthology
more info
 
enables type 1 metabotropic glutamate receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in RNA polymerase II preinitiation complex assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in RNA polymerase II preinitiation complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in Sertoli cell development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in Sertoli cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in androgen metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within androgen metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in antral ovarian follicle growth IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within antral ovarian follicle growth ISO
Inferred from Sequence Orthology
more info
 
involved_in baculum development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to estradiol stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to estradiol stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to estradiol stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to estrogen stimulus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to estrogen stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to estrogen stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within cellular response to estrogen stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to wortmannin IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in decidualization IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in epithelial cell development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within epithelial cell development ISO
Inferred from Sequence Orthology
more info
 
involved_in epithelial cell proliferation involved in mammary gland duct elongation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within epithelial cell proliferation involved in mammary gland duct elongation ISO
Inferred from Sequence Orthology
more info
 
involved_in estrogen receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in estrogen receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in estrogen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in male gonad development IEA
Inferred from Electronic Annotation
more info
 
involved_in male gonad development IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within male gonad development ISO
Inferred from Sequence Orthology
more info
 
involved_in mammary gland alveolus development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within mammary gland alveolus development ISO
Inferred from Sequence Orthology
more info
 
involved_in mammary gland branching involved in pregnancy IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within mammary gland branching involved in pregnancy ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of D-glucose import IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of canonical NF-kappaB signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of miRNA transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of miRNA transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of smooth muscle cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of triglyceride metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nuclear receptor-mediated steroid hormone signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in osteoblast development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of epidermal growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of nitric oxide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of nitric-oxide synthase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of nitric-oxide synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
involved_in prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in prostate epithelial cord elongation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within prostate epithelial cord elongation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to chromatin IEA
Inferred from Electronic Annotation
more info
 
involved_in protein localization to chromatin ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of branching involved in prostate gland morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of branching involved in prostate gland morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of epithelial cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of epithelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of toll-like receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of toll-like receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to estradiol ISO
Inferred from Sequence Orthology
more info
 
involved_in response to estrogen ISO
Inferred from Sequence Orthology
more info
 
involved_in stem cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in stem cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in steroid hormone receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in steroid hormone receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in uterus development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within uterus development ISO
Inferred from Sequence Orthology
more info
 
involved_in vagina development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within vagina development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in T-tubule IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in euchromatin IEA
Inferred from Electronic Annotation
more info
 
located_in euchromatin ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perikaryon IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in terminal bouton IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription regulator complex IEA
Inferred from Electronic Annotation
more info
 
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
estrogen receptor
Names
C-terminally-truncated estrogen receptor alpha product-1
Er alpha
estradiol receptor
estrogen receptor 1 (alpha)
estrogen receptor alpha i45aL
estrogen receptor alpha i45aS
estrogen receptor alpha i45c
estrogen receptor alpha i56a
estrogen receptor alpha i56b
estrogen receptor alpha i56c
estrogen receptor alpha i56dL
estrogen receptor alpha i56dS
estrogen receptor alpha i56e
estrogen receptor alpha variant delta 4
estrogen receptor protein
nuclear receptor subfamily 3 group A member 1
trunctaed estrogen receptor product-1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001433730.1NP_001420659.1  estrogen receptor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
  2. NM_001433731.1NP_001420660.1  estrogen receptor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
  3. NM_012689.2NP_036821.2  estrogen receptor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    Related
    ENSRNOP00000071400.1, ENSRNOT00000078494.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    43511685..43904454
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039101049.2XP_038956977.1  estrogen receptor isoform X3

    UniProtKB/TrEMBL
    A0A1W7GYV1
    Conserved Domains (3) summary
    cd07171
    Location:218299
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam02159
    Location:75219
    Oest_recep; Oestrogen receptor
    cl11397
    Location:348454
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  2. XM_017588797.3XP_017444286.2  estrogen receptor isoform X6

    UniProtKB/TrEMBL
    A0A0G2K0D4
    Conserved Domains (4) summary
    cd06949
    Location:348617
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:218299
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam02159
    Location:75219
    Oest_recep; Oestrogen receptor
    pfam12743
    Location:626665
    ESR1_C; Oestrogen-type nuclear receptor final C-terminal
  3. XM_039101051.2XP_038956979.1  estrogen receptor isoform X4

    UniProtKB/TrEMBL
    A0A8I6AKJ6
    Conserved Domains (3) summary
    cd07171
    Location:218299
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam02159
    Location:75219
    Oest_recep; Oestrogen receptor
    cl11397
    Location:348450
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  4. XM_039101033.2XP_038956961.1  estrogen receptor isoform X1

    UniProtKB/TrEMBL
    A6KIM0
    Conserved Domains (4) summary
    cd06949
    Location:348585
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:218299
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam02159
    Location:75219
    Oest_recep; Oestrogen receptor
    pfam12743
    Location:594633
    ESR1_C; Oestrogen-type nuclear receptor final C-terminal
  5. XM_039101029.2XP_038956957.1  estrogen receptor isoform X1

    UniProtKB/TrEMBL
    A6KIM0
    Conserved Domains (4) summary
    cd06949
    Location:348585
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:218299
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam02159
    Location:75219
    Oest_recep; Oestrogen receptor
    pfam12743
    Location:594633
    ESR1_C; Oestrogen-type nuclear receptor final C-terminal
  6. XM_017588795.3XP_017444284.1  estrogen receptor isoform X2

    UniProtKB/TrEMBL
    A0A0G2JZG2, A0A9K3Y766, D0FYH4, F1M839
    Conserved Domains (4) summary
    cd06949
    Location:315552
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:185266
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam02159
    Location:42186
    Oest_recep; Oestrogen receptor
    pfam12743
    Location:561600
    ESR1_C; Oestrogen-type nuclear receptor final C-terminal
  7. XM_006227832.5XP_006227894.1  estrogen receptor isoform X2

    See identical proteins and their annotated locations for XP_006227894.1

    UniProtKB/TrEMBL
    A0A0G2JZG2, A0A9K3Y766, D0FYH4, F1M839
    Conserved Domains (4) summary
    cd06949
    Location:315552
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:185266
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam02159
    Location:42186
    Oest_recep; Oestrogen receptor
    pfam12743
    Location:561600
    ESR1_C; Oestrogen-type nuclear receptor final C-terminal
  8. XM_008758704.4XP_008756926.1  estrogen receptor isoform X2

    See identical proteins and their annotated locations for XP_008756926.1

    UniProtKB/TrEMBL
    A0A0G2JZG2, A0A9K3Y766, D0FYH4, F1M839
    Conserved Domains (4) summary
    cd06949
    Location:315552
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:185266
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam02159
    Location:42186
    Oest_recep; Oestrogen receptor
    pfam12743
    Location:561600
    ESR1_C; Oestrogen-type nuclear receptor final C-terminal
  9. XM_063281065.1XP_063137135.1  estrogen receptor isoform X2

    UniProtKB/TrEMBL
    A0A9K3Y766, D0FYH4, F1M839
  10. XM_017588796.3XP_017444285.1  estrogen receptor isoform X5