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Bax BCL2 associated X, apoptosis regulator [ Rattus norvegicus (Norway rat) ]

Gene ID: 24887, updated on 19-Aug-2018

Summary

Official Symbol
Baxprovided by RGD
Official Full Name
BCL2 associated X, apoptosis regulatorprovided by RGD
Primary source
RGD:2192
See related
Ensembl:ENSRNOG00000020876
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Bcl2-related gene; involved in the regulation of apoptotic cell death [RGD, Feb 2006]
Expression
Biased expression in Spleen (RPKM 111.1), Thymus (RPKM 105.0) and 9 other tissues See more
Orthologs

Genomic context

See Bax in Genome Data Viewer
Location:
1q22
Exon count:
6
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (101451801..101457207, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (102530747..102536153, complement)

Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene glycogen synthase 1 Neighboring gene ferritin light chain 1 Neighboring gene dihydrodiol dehydrogenase Neighboring gene tubby-like protein 2 Neighboring gene nucleobindin 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • AGE-RAGE signaling pathway in diabetic complications, organism-specific biosystem (from KEGG)
    AGE-RAGE signaling pathway in diabetic complications, organism-specific biosystemAdvanced glycation end products (AGEs) are a complex group of compounds produced through the non-enzymatic glycation and oxidation of proteins, lipids and nucleic acids, primarily due to aging and un...
  • AGE-RAGE signaling pathway in diabetic complications, conserved biosystem (from KEGG)
    AGE-RAGE signaling pathway in diabetic complications, conserved biosystemAdvanced glycation end products (AGEs) are a complex group of compounds produced through the non-enzymatic glycation and oxidation of proteins, lipids and nucleic acids, primarily due to aging and un...
  • ATM Signaling Pathway, organism-specific biosystem (from WikiPathways)
    ATM Signaling Pathway, organism-specific biosystem
    ATM Signaling Pathway
  • Activation, translocation and oligomerization of BAX, organism-specific biosystem (from REACTOME)
    Activation, translocation and oligomerization of BAX, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Amyotrophic lateral sclerosis (ALS), organism-specific biosystem (from KEGG)
    Amyotrophic lateral sclerosis (ALS), organism-specific biosystemAmyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord...
  • Amyotrophic lateral sclerosis (ALS), conserved biosystem (from KEGG)
    Amyotrophic lateral sclerosis (ALS), conserved biosystemAmyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord...
  • Apoptosis, organism-specific biosystem (from KEGG)
    Apoptosis, organism-specific biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
  • Apoptosis, organism-specific biosystem (from WikiPathways)
    Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
  • Apoptosis, conserved biosystem (from KEGG)
    Apoptosis, conserved biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
  • Apoptosis, organism-specific biosystem (from REACTOME)
    Apoptosis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Apoptosis - multiple species, organism-specific biosystem (from KEGG)
    Apoptosis - multiple species, organism-specific biosystemApoptosis is an evolutionarily conserved process used by multicellular organisms to developmentally regulate cell number or to eliminate cells that are potentially detrimental to the organism. The ma...
  • Apoptosis - multiple species, conserved biosystem (from KEGG)
    Apoptosis - multiple species, conserved biosystemApoptosis is an evolutionarily conserved process used by multicellular organisms to developmentally regulate cell number or to eliminate cells that are potentially detrimental to the organism. The ma...
  • Colorectal cancer, organism-specific biosystem (from KEGG)
    Colorectal cancer, organism-specific biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
  • Colorectal cancer, conserved biosystem (from KEGG)
    Colorectal cancer, conserved biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
  • EGFR tyrosine kinase inhibitor resistance, organism-specific biosystem (from KEGG)
    EGFR tyrosine kinase inhibitor resistance, organism-specific biosystemEGFR is a tyrosine kinase that participates in the regulation of cellular homeostasis. EGFR also serves as a stimulus for cancer growth. EGFR gene mutations and protein overexpression, both of which ...
  • EGFR tyrosine kinase inhibitor resistance, conserved biosystem (from KEGG)
    EGFR tyrosine kinase inhibitor resistance, conserved biosystemEGFR is a tyrosine kinase that participates in the regulation of cellular homeostasis. EGFR also serves as a stimulus for cancer growth. EGFR gene mutations and protein overexpression, both of which ...
  • Endocrine resistance, organism-specific biosystem (from KEGG)
    Endocrine resistance, organism-specific biosystemEndocrine therapy is a key treatment strategy to control or eradicate hormone-responsive breast cancer. The most commonly used endocrine therapy agents are selective estrogen receptor modulators (SER...
  • Endocrine resistance, conserved biosystem (from KEGG)
    Endocrine resistance, conserved biosystemEndocrine therapy is a key treatment strategy to control or eradicate hormone-responsive breast cancer. The most commonly used endocrine therapy agents are selective estrogen receptor modulators (SER...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • HTLV-I infection, organism-specific biosystem (from KEGG)
    HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • HTLV-I infection, conserved biosystem (from KEGG)
    HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • Hepatitis B, organism-specific biosystem (from KEGG)
    Hepatitis B, organism-specific biosystemHepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and...
  • Huntington's disease, organism-specific biosystem (from KEGG)
    Huntington's disease, organism-specific biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
  • Huntington's disease, conserved biosystem (from KEGG)
    Huntington's disease, conserved biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
  • IL-3 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-3 Signaling Pathway, organism-specific biosystemInterleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common b...
  • IL-5 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-5 Signaling Pathway, organism-specific biosystem
    IL-5 Signaling Pathway
  • Intrinsic Pathway for Apoptosis, organism-specific biosystem (from REACTOME)
    Intrinsic Pathway for Apoptosis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Longevity regulating pathway, organism-specific biosystem (from KEGG)
    Longevity regulating pathway, organism-specific biosystemRegulation of longevity depends on genetic and environmental factors. Caloric restriction (CR), that is limiting food intake, is recognized in mammals as the best characterized and most reproducible ...
  • Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
    Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
  • Neurotrophin signaling pathway, conserved biosystem (from KEGG)
    Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
  • Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystem (from KEGG)
    Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
  • Non-alcoholic fatty liver disease (NAFLD), conserved biosystem (from KEGG)
    Non-alcoholic fatty liver disease (NAFLD), conserved biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
  • Pathways in cancer, organism-specific biosystem (from KEGG)
    Pathways in cancer, organism-specific biosystem
    Pathways in cancer
  • Platinum drug resistance, organism-specific biosystem (from KEGG)
    Platinum drug resistance, organism-specific biosystemPlatinum-based drugs cisplatin, carboplatin and oxaliplatin are widely used in the therapy of solid malignancies, including testicular, ovarian, head and neck, colorectal, bladder and lung cancers. T...
  • Platinum drug resistance, conserved biosystem (from KEGG)
    Platinum drug resistance, conserved biosystemPlatinum-based drugs cisplatin, carboplatin and oxaliplatin are widely used in the therapy of solid malignancies, including testicular, ovarian, head and neck, colorectal, bladder and lung cancers. T...
  • Prion diseases, organism-specific biosystem (from KEGG)
    Prion diseases, organism-specific biosystemPrion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal neurodegenerative diseases that affect humans and a number of other animal species. The etiology of ...
  • Prion diseases, conserved biosystem (from KEGG)
    Prion diseases, conserved biosystemPrion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal neurodegenerative diseases that affect humans and a number of other animal species. The etiology of ...
  • Programmed Cell Death, organism-specific biosystem (from REACTOME)
    Programmed Cell Death, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
  • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
  • Relationship between glutathione and NADPH, organism-specific biosystem (from WikiPathways)
    Relationship between glutathione and NADPH, organism-specific biosystem
    Relationship between glutathione and NADPH
  • Sphingolipid signaling pathway, organism-specific biosystem (from KEGG)
    Sphingolipid signaling pathway, organism-specific biosystemSphingomyelin (SM) and its metabolic products are now known to have second messenger functions in a variety of cellular signaling pathways. Particularly, the sphingolipid metabolites, ceramide (Cer) ...
  • Sphingolipid signaling pathway, conserved biosystem (from KEGG)
    Sphingolipid signaling pathway, conserved biosystemSphingomyelin (SM) and its metabolic products are now known to have second messenger functions in a variety of cellular signaling pathways. Particularly, the sphingolipid metabolites, ceramide (Cer) ...
  • TP53 Regulates Transcription of Cell Cycle Genes, organism-specific biosystem (from REACTOME)
    TP53 Regulates Transcription of Cell Cycle Genes, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest, organism-specific biosystem (from REACTOME)
    TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Transcriptional Regulation by TP53, organism-specific biosystem (from REACTOME)
    Transcriptional Regulation by TP53, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Tuberculosis, organism-specific biosystem (from KEGG)
    Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
  • Tuberculosis, conserved biosystem (from KEGG)
    Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
  • Viral carcinogenesis, organism-specific biosystem (from KEGG)
    Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
  • Viral carcinogenesis, conserved biosystem (from KEGG)
    Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
  • p53 pathway, organism-specific biosystem (from WikiPathways)
    p53 pathway, organism-specific biosystemp53 (also known as protein 53 or tumor protein 53), is a transcription factor which in humans is encoded by the TP53 gene. p53 is important in multicellular organisms, where it regulates the cell cyc...
  • p53 signal pathway, organism-specific biosystem (from WikiPathways)
    p53 signal pathway, organism-specific biosystemWe've used the following pathway as a reference: http://www.genome.jp/dbget-bin/show_pathway?rno04115+58918
  • p53 signaling pathway, organism-specific biosystem (from KEGG)
    p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
  • p53 signaling pathway, conserved biosystem (from KEGG)
    p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
BH domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
BH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
BH3 domain binding ISO
Inferred from Sequence Orthology
more info
 
BH3 domain binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Hsp70 protein binding IEA
Inferred from Electronic Annotation
more info
 
Hsp70 protein binding ISO
Inferred from Sequence Orthology
more info
 
channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
channel activity IEA
Inferred from Electronic Annotation
more info
 
channel activity ISO
Inferred from Sequence Orthology
more info
 
channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
chaperone binding IEA
Inferred from Electronic Annotation
more info
 
chaperone binding IPI
Inferred from Physical Interaction
more info
PubMed 
chaperone binding ISO
Inferred from Sequence Orthology
more info
 
heat shock protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
lipid binding IEA
Inferred from Electronic Annotation
more info
 
lipid binding ISO
Inferred from Sequence Orthology
more info
 
lipid binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
B cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
B cell apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
B cell homeostasis IEA
Inferred from Electronic Annotation
more info
 
B cell homeostasis ISO
Inferred from Sequence Orthology
more info
 
B cell homeostatic proliferation IEA
Inferred from Electronic Annotation
more info
 
B cell homeostatic proliferation ISO
Inferred from Sequence Orthology
more info
 
B cell negative selection IEA
Inferred from Electronic Annotation
more info
 
B cell negative selection ISO
Inferred from Sequence Orthology
more info
 
B cell receptor apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
B cell receptor apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Sertoli cell proliferation IEA
Inferred from Electronic Annotation
more info
 
Sertoli cell proliferation ISO
Inferred from Sequence Orthology
more info
 
T cell homeostatic proliferation IEA
Inferred from Electronic Annotation
more info
 
T cell homeostatic proliferation ISO
Inferred from Sequence Orthology
more info
 
activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
activation of cysteine-type endopeptidase activity involved in apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c IEA
Inferred from Electronic Annotation
more info
 
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c ISO
Inferred from Sequence Orthology
more info
 
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c ISS
Inferred from Sequence or Structural Similarity
more info
 
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
aging IEP
Inferred from Expression Pattern
more info
PubMed 
apoptotic mitochondrial changes ISO
Inferred from Sequence Orthology
more info
 
apoptotic mitochondrial changes ISS
Inferred from Sequence or Structural Similarity
more info
 
apoptotic process IEP
Inferred from Expression Pattern
more info
PubMed 
apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
apoptotic process ISO
Inferred from Sequence Orthology
more info
 
apoptotic process involved in blood vessel morphogenesis IEA
Inferred from Electronic Annotation
more info
 
apoptotic process involved in blood vessel morphogenesis ISO
Inferred from Sequence Orthology
more info
 
apoptotic process involved in embryonic digit morphogenesis IEA
Inferred from Electronic Annotation
more info
 
apoptotic process involved in embryonic digit morphogenesis ISO
Inferred from Sequence Orthology
more info
 
apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
apoptotic signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
blood vessel remodeling IEA
Inferred from Electronic Annotation
more info
 
blood vessel remodeling ISO
Inferred from Sequence Orthology
more info
 
brain development IEP
Inferred from Expression Pattern
more info
PubMed 
cell proliferation ISO
Inferred from Sequence Orthology
more info
 
cellular respiration IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to UV IEA
Inferred from Electronic Annotation
more info
 
cellular response to UV ISO
Inferred from Sequence Orthology
more info
 
cellular response to organic substance IEA
Inferred from Electronic Annotation
more info
 
cellular response to organic substance ISO
Inferred from Sequence Orthology
more info
 
cerebral cortex development IEA
Inferred from Electronic Annotation
more info
 
cerebral cortex development IEP
Inferred from Expression Pattern
more info
PubMed 
cerebral cortex development ISO
Inferred from Sequence Orthology
more info
 
development of secondary sexual characteristics IEA
Inferred from Electronic Annotation
more info
 
development of secondary sexual characteristics ISO
Inferred from Sequence Orthology
more info
 
ectopic germ cell programmed cell death IEA
Inferred from Electronic Annotation
more info
 
ectopic germ cell programmed cell death ISO
Inferred from Sequence Orthology
more info
 
establishment or maintenance of transmembrane electrochemical gradient IEA
Inferred from Electronic Annotation
more info
 
establishment or maintenance of transmembrane electrochemical gradient ISO
Inferred from Sequence Orthology
more info
 
establishment or maintenance of transmembrane electrochemical gradient ISS
Inferred from Sequence or Structural Similarity
more info
 
extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
extrinsic apoptotic signaling pathway in absence of ligand IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
 
extrinsic apoptotic signaling pathway in absence of ligand ISO
Inferred from Sequence Orthology
more info
 
extrinsic apoptotic signaling pathway via death domain receptors IEA
Inferred from Electronic Annotation
more info
 
extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
 
fertilization IEA
Inferred from Electronic Annotation
more info
 
fertilization ISO
Inferred from Sequence Orthology
more info
 
germ cell development IEA
Inferred from Electronic Annotation
more info
 
germ cell development ISO
Inferred from Sequence Orthology
more info
 
glial cell apoptotic process IEP
Inferred from Expression Pattern
more info
PubMed 
glycosphingolipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
glycosphingolipid metabolic process ISO
Inferred from Sequence Orthology
more info
 
homeostasis of number of cells ISO
Inferred from Sequence Orthology
more info
 
homeostasis of number of cells within a tissue IEA
Inferred from Electronic Annotation
more info
 
homeostasis of number of cells within a tissue ISO
Inferred from Sequence Orthology
more info
 
hypothalamus development IEA
Inferred from Electronic Annotation
more info
 
hypothalamus development ISO
Inferred from Sequence Orthology
more info
 
inner mitochondrial membrane organization IDA
Inferred from Direct Assay
more info
PubMed 
intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
intrinsic apoptotic signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
intrinsic apoptotic signaling pathway by p53 class mediator IEA
Inferred from Electronic Annotation
more info
 
intrinsic apoptotic signaling pathway by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
intrinsic apoptotic signaling pathway in response to DNA damage IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intrinsic apoptotic signaling pathway in response to DNA damage IEA
Inferred from Electronic Annotation
more info
 
intrinsic apoptotic signaling pathway in response to DNA damage ISO
Inferred from Sequence Orthology
more info
 
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IEA
Inferred from Electronic Annotation
more info
 
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
 
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress ISS
Inferred from Sequence or Structural Similarity
more info
 
kidney development IEA
Inferred from Electronic Annotation
more info
 
kidney development ISO
Inferred from Sequence Orthology
more info
 
leukocyte homeostasis ISO
Inferred from Sequence Orthology
more info
 
limb morphogenesis ISO
Inferred from Sequence Orthology
more info
 
male gonad development ISO
Inferred from Sequence Orthology
more info
 
mitochondrial fragmentation involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
mitochondrial fragmentation involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
mitochondrial fragmentation involved in apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrial fusion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial fusion IEA
Inferred from Electronic Annotation
more info
 
mitochondrial fusion ISO
Inferred from Sequence Orthology
more info
 
mitochondrial fusion ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrion morphogenesis IEA
Inferred from Electronic Annotation
more info
 
mitochondrion morphogenesis ISO
Inferred from Sequence Orthology
more info
 
myeloid cell homeostasis IEA
Inferred from Electronic Annotation
more info
 
myeloid cell homeostasis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of endoplasmic reticulum calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
negative regulation of endoplasmic reticulum calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein binding IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
nervous system development ISO
Inferred from Sequence Orthology
more info
 
neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
neuron migration IEA
Inferred from Electronic Annotation
more info
 
neuron migration ISO
Inferred from Sequence Orthology
more info
 
odontogenesis of dentin-containing tooth IEA
Inferred from Electronic Annotation
more info
 
odontogenesis of dentin-containing tooth ISO
Inferred from Sequence Orthology
more info
 
outer mitochondrial membrane organization IDA
Inferred from Direct Assay
more info
PubMed 
ovarian follicle development IEA
Inferred from Electronic Annotation
more info
 
ovarian follicle development IEP
Inferred from Expression Pattern
more info
PubMed 
ovarian follicle development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of B cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of B cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic DNA fragmentation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic DNA fragmentation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of apoptotic process involved in mammary gland involution IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic process involved in mammary gland involution ISO
Inferred from Sequence Orthology
more info
 
positive regulation of calcium ion transport into cytosol ISO
Inferred from Sequence Orthology
more info
 
positive regulation of developmental pigmentation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of developmental pigmentation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endoplasmic reticulum unfolded protein response IEA
Inferred from Electronic Annotation
more info
 
positive regulation of endoplasmic reticulum unfolded protein response ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endoplasmic reticulum unfolded protein response ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
 
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
Inferred from Sequence Orthology
more info
 
positive regulation of intrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of intrinsic apoptotic signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of mitochondrial membrane permeability involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein oligomerization IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein oligomerization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein oligomerization ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of release of cytochrome c from mitochondria IEA
Inferred from Electronic Annotation
more info
 
positive regulation of release of cytochrome c from mitochondria ISO
Inferred from Sequence Orthology
more info
 
positive regulation of release of cytochrome c from mitochondria ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of release of sequestered calcium ion into cytosol IEA
Inferred from Electronic Annotation
more info
 
positive regulation of release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
 
post-embryonic camera-type eye morphogenesis IEA
Inferred from Electronic Annotation
more info
 
post-embryonic camera-type eye morphogenesis ISO
Inferred from Sequence Orthology
more info
 
post-embryonic development ISO
Inferred from Sequence Orthology
more info
 
protein complex oligomerization ISO
Inferred from Sequence Orthology
more info
 
protein homooligomerization IEA
Inferred from Electronic Annotation
more info
 
protein homooligomerization ISO
Inferred from Sequence Orthology
more info
 
protein insertion into mitochondrial membrane involved in apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
protein insertion into mitochondrial membrane involved in apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
regulation of mammary gland epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
regulation of mammary gland epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
regulation of mitochondrial membrane permeability involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
regulation of mitochondrial membrane permeability involved in programmed necrotic cell death IEA
Inferred from Electronic Annotation
more info
 
regulation of mitochondrial membrane permeability involved in programmed necrotic cell death ISO
Inferred from Sequence Orthology
more info
 
regulation of mitochondrial membrane potential IEA
Inferred from Electronic Annotation
more info
 
regulation of mitochondrial membrane potential ISO
Inferred from Sequence Orthology
more info
 
NOT regulation of mitochondrial membrane potential ISO
Inferred from Sequence Orthology
more info
 
regulation of mitochondrial membrane potential ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
regulation of nitrogen utilization IEA
Inferred from Electronic Annotation
more info
 
regulation of nitrogen utilization ISO
Inferred from Sequence Orthology
more info
 
regulation of protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
regulation of protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
regulation of protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
regulation of protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
regulation of protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
release of cytochrome c from mitochondria IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
release of cytochrome c from mitochondria IEA
Inferred from Electronic Annotation
more info
 
release of cytochrome c from mitochondria ISO
Inferred from Sequence Orthology
more info
 
release of matrix enzymes from mitochondria IEA
Inferred from Electronic Annotation
more info
 
release of matrix enzymes from mitochondria ISO
Inferred from Sequence Orthology
more info
 
release of matrix enzymes from mitochondria ISS
Inferred from Sequence or Structural Similarity
more info
 
response to axon injury IEA
Inferred from Electronic Annotation
more info
 
response to axon injury ISO
Inferred from Sequence Orthology
more info
 
response to cocaine IEP
Inferred from Expression Pattern
more info
PubMed 
response to copper ion IEP
Inferred from Expression Pattern
more info
PubMed 
response to corticosterone IEP
Inferred from Expression Pattern
more info
PubMed 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to gamma radiation IEA
Inferred from Electronic Annotation
more info
 
response to gamma radiation ISO
Inferred from Sequence Orthology
more info
 
response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
 
response to salt stress IEA
Inferred from Electronic Annotation
more info
 
response to salt stress ISO
Inferred from Sequence Orthology
more info
 
response to toxic substance IEA
Inferred from Electronic Annotation
more info
 
response to toxic substance ISO
Inferred from Sequence Orthology
more info
 
response to toxic substance ISS
Inferred from Sequence or Structural Similarity
more info
 
response to wounding ISO
Inferred from Sequence Orthology
more info
 
retina development in camera-type eye IEA
Inferred from Electronic Annotation
more info
 
retina development in camera-type eye ISO
Inferred from Sequence Orthology
more info
 
retinal cell programmed cell death IEA
Inferred from Electronic Annotation
more info
 
retinal cell programmed cell death ISO
Inferred from Sequence Orthology
more info
 
sex differentiation ISO
Inferred from Sequence Orthology
more info
 
spermatid differentiation IEA
Inferred from Electronic Annotation
more info
 
spermatid differentiation ISO
Inferred from Sequence Orthology
more info
 
spermatogenesis ISO
Inferred from Sequence Orthology
more info
 
thymocyte apoptotic process IEA
Inferred from Electronic Annotation
more info
 
thymocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
 
vagina development IEA
Inferred from Electronic Annotation
more info
 
vagina development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
BAX complex IEA
Inferred from Electronic Annotation
more info
 
BAX complex ISO
Inferred from Sequence Orthology
more info
 
BAX complex ISS
Inferred from Sequence or Structural Similarity
more info
 
Bcl-2 family protein complex ISO
Inferred from Sequence Orthology
more info
 
Bcl-2 family protein complex ISS
Inferred from Sequence or Structural Similarity
more info
 
cell periphery IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with cell periphery ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular ISO
Inferred from Sequence Orthology
more info
 
mitochondrial membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
 
mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
mitochondrial permeability transition pore complex IEA
Inferred from Electronic Annotation
more info
 
mitochondrial permeability transition pore complex ISO
Inferred from Sequence Orthology
more info
 
mitochondrial permeability transition pore complex ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
nuclear envelope IEA
Inferred from Electronic Annotation
more info
 
nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
pore complex ISO
Inferred from Sequence Orthology
more info
 
pore complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
apoptosis regulator BAX
Names
Bcl2-associated X protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017059.2NP_058755.2  apoptosis regulator BAX

    See identical proteins and their annotated locations for NP_058755.2

    Status: VALIDATED

    Source sequence(s)
    AF235993, CB586216
    UniProtKB/TrEMBL
    G3V8T9, Q9JKL3
    Related
    ENSRNOP00000028328.2, ENSRNOT00000028328.5
    Conserved Domains (2) summary
    cd06845
    Location:25164
    Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
    TIGR00865
    Location:13192
    bcl-2; apoptosis regulator

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

    Range
    101451801..101457207 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000069.1 Alternate Rn_Celera

    Range
    90195913..90201319 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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