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Wnt1 Wnt family member 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24881, updated on 30-Sep-2021

Summary

Official Symbol
Wnt1provided by RGD
Official Full Name
Wnt family member 1provided by RGD
Primary source
RGD:1597195
See related
EnsemblRapid:ENSRNOG00000061818
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Int1
Summary
mouse homolog promotes development of midbrain dopaminergic (DA) neurons [RGD, Feb 2006]
Expression
Restricted expression toward (RPKM 1.8) See more
Orthologs
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Genomic context

See Wnt1 in Genome Data Viewer
Location:
7q36
Exon count:
4
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (129938604..129942651)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (140464999..140469046)

Chromosome 7 - NC_051342.1Genomic Context describing neighboring genes Neighboring gene Wnt family member 10B Neighboring gene transfer RNA lysine (anticodon UUU) Neighboring gene uncharacterized LOC102555574 Neighboring gene dendrin Neighboring gene protein kinase AMP-activated non-catalytic subunit gamma 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cytokine activity ISO
Inferred from Sequence Orthology
more info
 
enables frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables molecular_function ND
No biological Data available
more info
 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables receptor ligand activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in Spemann organizer formation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within T cell differentiation in thymus ISO
Inferred from Sequence Orthology
more info
 
involved_in Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in animal organ regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in astrocyte-dopaminergic neuron signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in bone development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in cell fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell proliferation in midbrain ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-cell signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to peptide hormone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in central nervous system morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in cerebellum development ISO
Inferred from Sequence Orthology
more info
 
involved_in cerebellum formation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within diencephalon development ISO
Inferred from Sequence Orthology
more info
 
involved_in dopaminergic neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in embryonic axis specification ISO
Inferred from Sequence Orthology
more info
 
involved_in embryonic brain development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within forebrain anterior/posterior pattern specification ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within hematopoietic stem cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in hepatocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within inner ear morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within metencephalon development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within midbrain development ISO
Inferred from Sequence Orthology
more info
 
involved_in midbrain development ISO
Inferred from Sequence Orthology
more info
 
involved_in midbrain dopaminergic neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within midbrain-hindbrain boundary development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within midbrain-hindbrain boundary maturation during brain development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within myoblast fusion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within myotube differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell aging ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of oxidative stress-induced neuron death ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in neurogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within neuron fate commitment ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuron fate determination ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dermatome development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of insulin-like growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of lamellipodium assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in response to wounding ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction in response to DNA damage ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within spinal cord association neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ubiquitin-dependent SMAD protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
is_active_in cellular_component ND
No biological Data available
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
proto-oncogene Wnt-1
Names
Wingless-type MMTV integration site 1, homolog
wingless-related MMTV integration site 1
wingless-type MMTV integration site family, member 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105714.1NP_001099184.1  proto-oncogene Wnt-1 precursor

    See identical proteins and their annotated locations for NP_001099184.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474035
    UniProtKB/TrEMBL
    D4A9J2
    Related
    ENSRNOP00000071688.1, ENSRNOT00000090156.2
    Conserved Domains (1) summary
    cd19333
    Location:64370
    Wnt_Wnt1; Wnt domain found in proto-oncogene Wnt-1 and similar proteins

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051342.1 Reference mRatBN7.2 Primary Assembly

    Range
    129938604..129942651
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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