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Clu clusterin [ Rattus norvegicus (Norway rat) ]

Gene ID: 24854, updated on 19-Apr-2019

Summary

Official Symbol
Cluprovided by RGD
Official Full Name
clusterinprovided by RGD
Primary source
RGD:3907
See related
Ensembl:ENSRNOG00000016460
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CLI; DAG; APOJ; SGP2; SP40; SGP-2; SP-40; Trpm2; Trpmb; TRPM-2; TRPM2B; RATTRPM2B
Summary
The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders.[provided by RefSeq, May 2011]
Expression
Biased expression in Heart (RPKM 3647.0), Liver (RPKM 1803.6) and 7 other tissues See more
Orthologs

Genomic context

See Clu in Genome Data Viewer
Location:
15p12
Exon count:
11
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (42626612..42665858)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 15 NC_005114.3 (48926511..48965757, complement)

Chromosome 15 - NC_005114.4Genomic Context describing neighboring genes Neighboring gene glioma tumor suppressor candidate region gene 2 protein-like Neighboring gene coiled-coil domain containing 25 Neighboring gene uncharacterized LOC108352932 Neighboring gene scavenger receptor class A, member 3 Neighboring gene serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like Neighboring gene gulonolactone (L-) oxidase Neighboring gene uncharacterized LOC102555773 Neighboring gene ADAM metallopeptidase domain 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
NOT ATPase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
NOT ATPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
amyloid-beta binding IEA
Inferred from Electronic Annotation
more info
 
amyloid-beta binding ISO
Inferred from Sequence Orthology
more info
PubMed 
chaperone binding ISO
Inferred from Sequence Orthology
more info
PubMed 
low-density lipoprotein particle receptor binding IEA
Inferred from Electronic Annotation
more info
 
low-density lipoprotein particle receptor binding ISO
Inferred from Sequence Orthology
more info
PubMed 
misfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
misfolded protein binding IEA
Inferred from Electronic Annotation
more info
 
misfolded protein binding ISO
Inferred from Sequence Orthology
more info
PubMed 
misfolded protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein N-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
PubMed 
signaling receptor binding ISO
Inferred from Sequence Orthology
more info
PubMed 
tau protein binding IEA
Inferred from Electronic Annotation
more info
 
tau protein binding ISO
Inferred from Sequence Orthology
more info
PubMed 
ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
PubMed 
ubiquitin protein ligase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
aging IEP
Inferred from Expression Pattern
more info
PubMed 
cell morphogenesis IEA
Inferred from Electronic Annotation
more info
 
cell morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
cell morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to growth factor stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
central nervous system myelin maintenance IEA
Inferred from Electronic Annotation
more info
 
central nervous system myelin maintenance ISO
Inferred from Sequence Orthology
more info
PubMed 
central nervous system myelin maintenance ISS
Inferred from Sequence or Structural Similarity
more info
 
chaperone-mediated protein complex assembly IEA
Inferred from Electronic Annotation
more info
 
chaperone-mediated protein complex assembly ISO
Inferred from Sequence Orthology
more info
PubMed 
chaperone-mediated protein complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
chaperone-mediated protein folding IEA
Inferred from Electronic Annotation
more info
 
chaperone-mediated protein folding ISO
Inferred from Sequence Orthology
more info
PubMed 
chaperone-mediated protein folding ISS
Inferred from Sequence or Structural Similarity
more info
 
endocrine pancreas development IMP
Inferred from Mutant Phenotype
more info
PubMed 
estrous cycle IEP
Inferred from Expression Pattern
more info
PubMed 
immune complex clearance IEA
Inferred from Electronic Annotation
more info
 
intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
intrinsic apoptotic signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
microglial cell activation IEA
Inferred from Electronic Annotation
more info
 
microglial cell activation ISO
Inferred from Sequence Orthology
more info
PubMed 
microglial cell activation ISS
Inferred from Sequence or Structural Similarity
more info
 
microglial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
microglial cell proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
microglial cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of amyloid fibril formation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of amyloid fibril formation ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of amyloid-beta formation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of amyloid-beta formation ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of amyloid-beta formation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell death ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of cellular response to thapsigargin IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cellular response to thapsigargin ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of cellular response to tunicamycin IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cellular response to tunicamycin ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IEA
Inferred from Electronic Annotation
more info
 
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of protein homooligomerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of protein homooligomerization IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein homooligomerization ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of protein homooligomerization ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of response to endoplasmic reticulum stress IEA
Inferred from Electronic Annotation
more info
 
negative regulation of response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
PubMed 
neuron projection morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of amyloid-beta formation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of amyloid-beta formation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of amyloid-beta formation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of intrinsic apoptotic signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of neurofibrillary tangle assembly IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neurofibrillary tangle assembly ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of neurofibrillary tangle assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of neuron death IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neuron death IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of neuron death ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of neuron death ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of nitric oxide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of nitric oxide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein homooligomerization IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein homooligomerization ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of receptor-mediated endocytosis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of tau-protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of tau-protein kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of tau-protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of tumor necrosis factor production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of tumor necrosis factor production ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
protein import IEA
Inferred from Electronic Annotation
more info
 
protein import ISO
Inferred from Sequence Orthology
more info
PubMed 
protein import ISS
Inferred from Sequence or Structural Similarity
more info
 
protein stabilization IDA
Inferred from Direct Assay
more info
PubMed 
protein stabilization IEA
Inferred from Electronic Annotation
more info
 
protein stabilization ISO
Inferred from Sequence Orthology
more info
PubMed 
protein stabilization ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of amyloid-beta clearance IEA
Inferred from Electronic Annotation
more info
 
regulation of amyloid-beta clearance ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of amyloid-beta clearance ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of neuron death ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of neuron death ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of neuronal signal transduction IEA
Inferred from Electronic Annotation
more info
 
regulation of neuronal signal transduction ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of neuronal signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
response to light stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
response to misfolded protein IEA
Inferred from Electronic Annotation
more info
 
response to misfolded protein ISO
Inferred from Sequence Orthology
more info
PubMed 
response to misfolded protein ISS
Inferred from Sequence or Structural Similarity
more info
 
response to potassium ion IEP
Inferred from Expression Pattern
more info
PubMed 
response to virus IEA
Inferred from Electronic Annotation
more info
 
response to virus ISO
Inferred from Sequence Orthology
more info
PubMed 
response to wounding IEP
Inferred from Expression Pattern
more info
PubMed 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
PubMed 
aggresome IDA
Inferred from Direct Assay
more info
PubMed 
apical dendrite IEA
Inferred from Electronic Annotation
more info
 
apical dendrite ISO
Inferred from Sequence Orthology
more info
PubMed 
apical dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
cell periphery IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with cell periphery ISO
Inferred from Sequence Orthology
more info
PubMed 
cell surface IEA
Inferred from Electronic Annotation
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
PubMed 
chromaffin granule IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with collagen-containing extracellular matrix ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with cytoskeleton ISO
Inferred from Sequence Orthology
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
PubMed 
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
PubMed 
extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
 
growth cone IDA
Inferred from Direct Assay
more info
PubMed 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
PubMed 
colocalizes_with membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
PubMed 
mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 
neurofibrillary tangle IEA
Inferred from Electronic Annotation
more info
 
neurofibrillary tangle ISO
Inferred from Sequence Orthology
more info
PubMed 
neurofibrillary tangle ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
perinuclear endoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
 
perinuclear endoplasmic reticulum lumen ISO
Inferred from Sequence Orthology
more info
PubMed 
perinuclear endoplasmic reticulum lumen ISS
Inferred from Sequence or Structural Similarity
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
PubMed 
spherical high-density lipoprotein particle IEA
Inferred from Electronic Annotation
more info
 
spherical high-density lipoprotein particle ISO
Inferred from Sequence Orthology
more info
PubMed 
spherical high-density lipoprotein particle ISS
Inferred from Sequence or Structural Similarity
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 
synapse ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
clusterin
Names
dimeric acid glycoprotein
sulfated glycoprotein 2
testosterone repressed prostate message 2
testosterone-repressed prostate message
testostrone-repressed prostate message 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053021.2NP_444180.2  clusterin precursor

    See identical proteins and their annotated locations for NP_444180.2

    Status: PROVISIONAL

    Source sequence(s)
    M16975
    UniProtKB/Swiss-Prot
    P05371
    Related
    ENSRNOP00000072116.1, ENSRNOT00000078861.1
    Conserved Domains (3) summary
    smart00030
    Location:22226
    CLb; CLUSTERIN Beta chain
    smart00035
    Location:227441
    CLa; CLUSTERIN alpha chain
    pfam01093
    Location:29443
    Clusterin; Clusterin

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005114.4 Reference Rnor_6.0 Primary Assembly

    Range
    42626612..42665858
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006252094.3XP_006252156.1  clusterin isoform X1

    See identical proteins and their annotated locations for XP_006252156.1

    UniProtKB/TrEMBL
    G3V836
    Related
    ENSRNOP00000022095.4, ENSRNOT00000022095.7
    Conserved Domains (3) summary
    smart00030
    Location:22226
    CLb; CLUSTERIN Beta chain
    smart00035
    Location:227441
    CLa; CLUSTERIN alpha chain
    pfam01093
    Location:29443
    Clusterin; Clusterin

Alternate Rn_Celera

Genomic

  1. AC_000083.1 Alternate Rn_Celera

    Range
    39832711..39871901
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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