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Tp53 tumor protein p53 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24842, updated on 27-Nov-2024

Summary

Official Symbol
Tp53provided by RGD
Official Full Name
tumor protein p53provided by RGD
Primary source
RGD:3889
See related
EnsemblRapid:ENSRNOG00000010756 AllianceGenome:RGD:3889
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
p53; Trp53
Summary
This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it is believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. p53 pseudogenes have been found on chromosomes 9 and 18. [provided by RefSeq, May 2024]
Expression
Biased expression in Spleen (RPKM 102.5), Thymus (RPKM 101.3) and 9 other tissues See more
Orthologs
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Genomic context

See Tp53 in Genome Data Viewer
Location:
10q24
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (54798871..54810300)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (54300070..54311525)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (56186299..56198449)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ephrin B3 Neighboring gene WD repeat containing, antisense to TP53 Neighboring gene ATPase Na+/K+ transporting subunit beta 2 Neighboring gene uncharacterized LOC134480815

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC112612

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 14-3-3 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables ATP-dependent DNA/DNA annealing activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP-dependent DNA/DNA annealing activity ISO
Inferred from Sequence Orthology
more info
 
enables ATP-dependent DNA/DNA annealing activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISS
Inferred from Sequence or Structural Similarity
more info
 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables MDM2/MDM4 family protein binding IEA
Inferred from Electronic Annotation
more info
 
enables MDM2/MDM4 family protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables MDM2/MDM4 family protein binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables TFIID-class transcription factor complex binding IEA
Inferred from Electronic Annotation
more info
 
enables TFIID-class transcription factor complex binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables copper ion binding IEA
Inferred from Electronic Annotation
more info
 
enables copper ion binding ISO
Inferred from Sequence Orthology
more info
 
enables copper ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables core promoter sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables core promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables disordered domain specific binding IEA
Inferred from Electronic Annotation
more info
 
enables disordered domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables general transcription initiation factor binding ISO
Inferred from Sequence Orthology
more info
 
enables histone deacetylase binding IEA
Inferred from Electronic Annotation
more info
 
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 
enables histone deacetylase regulator activity IEA
Inferred from Electronic Annotation
more info
 
enables histone deacetylase regulator activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA 3'-UTR binding IEA
Inferred from Electronic Annotation
more info
 
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular condensate scaffold activity IEA
Inferred from Electronic Annotation
more info
 
enables molecular condensate scaffold activity ISO
Inferred from Sequence Orthology
more info
 
enables molecular condensate scaffold activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables molecular function activator activity IEA
Inferred from Electronic Annotation
more info
 
enables molecular function activator activity ISO
Inferred from Sequence Orthology
more info
 
enables p53 binding IEA
Inferred from Electronic Annotation
more info
 
enables p53 binding ISO
Inferred from Sequence Orthology
more info
 
enables promoter-specific chromatin binding IEA
Inferred from Electronic Annotation
more info
 
enables promoter-specific chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables promoter-specific chromatin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protease binding IEA
Inferred from Electronic Annotation
more info
 
enables protease binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein phosphatase 2A binding IEA
Inferred from Electronic Annotation
more info
 
enables protein phosphatase 2A binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-folding chaperone binding IEA
Inferred from Electronic Annotation
more info
 
enables protein-folding chaperone binding ISO
Inferred from Sequence Orthology
more info
 
enables receptor tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
 
enables receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription cis-regulatory region binding IEA
Inferred from Electronic Annotation
more info
 
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription coregulator binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane transporter binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in B cell lineage commitment IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within B cell lineage commitment ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within DNA damage response ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA damage response ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within DNA damage response, signal transduction by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA damage response, signal transduction by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator ISO
Inferred from Sequence Orthology
more info
 
involved_in ER overload response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within ER overload response ISO
Inferred from Sequence Orthology
more info
 
involved_in Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in T cell differentiation in thymus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within T cell differentiation in thymus ISO
Inferred from Sequence Orthology
more info
 
involved_in T cell lineage commitment IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within T cell lineage commitment ISO
Inferred from Sequence Orthology
more info
 
involved_in T cell proliferation involved in immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within T cell proliferation involved in immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in bone marrow development IEA
Inferred from Electronic Annotation
more info
 
involved_in bone marrow development ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac muscle cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of cardiac muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac septum morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cardiac septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to UV ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to UV ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to UV-C IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to UV-C ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to actinomycin D IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to actinomycin D ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to gamma radiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to gamma radiation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to gamma radiation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to glucose starvation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to glucose starvation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to glucose starvation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to heat IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to polyamine macromolecule IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to reactive oxygen species IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to stress ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to triglyceride IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular senescence ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular senescence ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within central nervous system development ISO
Inferred from Sequence Orthology
more info
 
involved_in cerebellum development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cerebellum development ISO
Inferred from Sequence Orthology
more info
 
involved_in chromosome organization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within chromosome organization ISO
Inferred from Sequence Orthology
more info
 
involved_in circadian behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in circadian behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in circadian behavior ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in circadian rhythm ISO
Inferred from Sequence Orthology
more info
 
involved_in determination of adult lifespan IEA
Inferred from Electronic Annotation
more info
 
involved_in determination of adult lifespan ISO
Inferred from Sequence Orthology
more info
 
involved_in double-strand break repair IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within double-strand break repair ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryo development ending in birth or egg hatching ISO
Inferred from Sequence Orthology
more info
 
involved_in embryonic organ development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within embryonic organ development ISO
Inferred from Sequence Orthology
more info
 
involved_in entrainment of circadian clock by photoperiod IEA
Inferred from Electronic Annotation
more info
 
involved_in entrainment of circadian clock by photoperiod ISO
Inferred from Sequence Orthology
more info
 
involved_in entrainment of circadian clock by photoperiod ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in gastrulation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within gastrulation ISO
Inferred from Sequence Orthology
more info
 
involved_in glial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of glial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in glucose catabolic process to lactate via pyruvate IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of glucose catabolic process to lactate via pyruvate ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within heart development ISO
Inferred from Sequence Orthology
more info
 
involved_in hematopoietic progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in hematopoietic stem cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in hematopoietic stem cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
NOT acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within intrinsic apoptotic signaling pathway by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
involved_in intrinsic apoptotic signaling pathway by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IEA
Inferred from Electronic Annotation
more info
 
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
 
involved_in intrinsic apoptotic signaling pathway in response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in mRNA transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrial DNA repair IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within mitochondrial DNA repair ISO
Inferred from Sequence Orthology
more info
 
involved_in mitophagy IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of mitophagy ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mitotic G1 DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic G1 DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within multicellular organism growth ISO
Inferred from Sequence Orthology
more info
 
involved_in necroptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within necroptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA replication IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of G1 to G0 transition IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of G1 to G0 transition ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell growth IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell growth ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of glial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of glial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of glucose catabolic process to lactate via pyruvate IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of glucose catabolic process to lactate via pyruvate ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of miRNA processing IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of miRNA processing ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of mitophagy IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of mitophagy ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of neuroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of pentose-phosphate shunt IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of pentose-phosphate shunt ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of progesterone secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of proteolysis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of reactive oxygen species metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of stem cell proliferation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of stem cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of telomere maintenance via telomerase IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in neuroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of neuroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in nucleotide-excision repair IEA
Inferred from Electronic Annotation
more info
 
involved_in nucleotide-excision repair ISO
Inferred from Sequence Orthology
more info
 
involved_in nucleotide-excision repair ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in oligodendrocyte apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in oligodendrocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in oligodendrocyte apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in oxidative stress-induced premature senescence IEA
Inferred from Electronic Annotation
more info
 
involved_in oxidative stress-induced premature senescence ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of RNA polymerase II transcription preinitiation complex assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of RNA polymerase II transcription preinitiation complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cardiac muscle cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of cardiac muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cellular senescence IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of cellular senescence ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cellular senescence ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of execution phase of apoptosis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of execution phase of apoptosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of intrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of intrinsic apoptotic signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of leukocyte migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of miRNA transcription IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of miRNA transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of miRNA transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitochondrial membrane permeability IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of mitochondrial membrane permeability ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of outer hair cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of programmed necrotic cell death IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of programmed necrotic cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of reactive oxygen species metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of release of cytochrome c from mitochondria IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of release of cytochrome c from mitochondria ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of thymocyte apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of thymocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of thymocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in protein import into nucleus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein stabilization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein stabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein tetramerization IEA
Inferred from Electronic Annotation
more info
 
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in rRNA transcription IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within rRNA transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in reactive oxygen species metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA damage response, signal transduction by p53 class mediator IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of DNA damage response, signal transduction by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell cycle G2/M phase transition IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_negative_effect regulation of cell cycle G2/M phase transition ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cellular senescence ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of fibroblast apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of fibroblast apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of intracellular pH IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of intrinsic apoptotic signaling pathway by p53 class mediator IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of intrinsic apoptotic signaling pathway by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mitochondrial membrane permeability involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of mitochondrial membrane permeability involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of peptide hormone secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of prostaglandin secretion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of thymocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of tissue remodeling IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of tissue remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in release of cytochrome c from mitochondria IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within release of cytochrome c from mitochondria ISO
Inferred from Sequence Orthology
more info
 
involved_in replicative senescence IEA
Inferred from Electronic Annotation
more info
 
involved_in replicative senescence ISO
Inferred from Sequence Orthology
more info
 
involved_in response to UV IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within response to UV ISO
Inferred from Sequence Orthology
more info
 
involved_in response to UV-B IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to X-ray IEA
Inferred from Electronic Annotation
more info
 
involved_in response to X-ray IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to X-ray IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to X-ray ISO
Inferred from Sequence Orthology
more info
 
involved_in response to amino acid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to antibiotic ISO
Inferred from Sequence Orthology
more info
 
involved_in response to caffeine IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to cytokine IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within response to gamma radiation ISO
Inferred from Sequence Orthology
more info
 
involved_in response to gamma radiation ISO
Inferred from Sequence Orthology
more info
 
involved_in response to hyperoxia IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to ischemia IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within response to ischemia ISO
Inferred from Sequence Orthology
more info
 
involved_in response to metal ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to oxidative stress IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
involved_in response to retinoic acid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to salt stress IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within response to salt stress ISO
Inferred from Sequence Orthology
more info
 
involved_in response to vitamin B3 IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in rhythmic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within signal transduction by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
involved_in somitogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within somitogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in stem cell proliferation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of stem cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in thymocyte apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of thymocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in transcription initiation-coupled chromatin remodeling IEA
Inferred from Electronic Annotation
more info
 
involved_in transcription initiation-coupled chromatin remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in tumor necrosis factor-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in type II interferon-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in type II interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in viral process IEA
Inferred from Electronic Annotation
more info
 
involved_in viral process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in PML body IDA
Inferred from Direct Assay
more info
PubMed 
located_in PML body IEA
Inferred from Electronic Annotation
more info
 
located_in PML body ISO
Inferred from Sequence Orthology
more info
 
part_of RNA polymerase II transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome IEA
Inferred from Electronic Annotation
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromatin IEA
Inferred from Electronic Annotation
more info
 
located_in chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in germ cell nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in germ cell nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear matrix IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear matrix ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in replication fork IEA
Inferred from Electronic Annotation
more info
 
located_in replication fork ISO
Inferred from Sequence Orthology
more info
 
located_in site of double-strand break IEA
Inferred from Electronic Annotation
more info
 
located_in site of double-strand break ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 
part_of transcription repressor complex IEA
Inferred from Electronic Annotation
more info
 
part_of transcription repressor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cellular tumor antigen p53
Names
transformation related protein 53
tumor protein p53 (Li-Fraumeni syndrome)
tumor suppressor p53

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429993.1NP_001416922.1  cellular tumor antigen p53 isoform a

    Status: REVIEWED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    O09168, P10361, Q4KMA9, Q66HM0
    UniProtKB/TrEMBL
    A6HFR6
  2. NM_001429994.1NP_001416923.1  cellular tumor antigen p53 isoform a

    Status: REVIEWED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    O09168, P10361, Q4KMA9, Q66HM0
    UniProtKB/TrEMBL
    A6HFR6
  3. NM_001429995.1NP_001416924.1  cellular tumor antigen p53 isoform b

    Status: REVIEWED

    Source sequence(s)
    JAXUCZ010000010
  4. NM_001429996.1NP_001416925.1  cellular tumor antigen p53 isoform b

    Status: REVIEWED

    Source sequence(s)
    JAXUCZ010000010
  5. NM_030989.4NP_112251.2  cellular tumor antigen p53 isoform a

    See identical proteins and their annotated locations for NP_112251.2

    Status: REVIEWED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    O09168, P10361, Q4KMA9, Q66HM0
    UniProtKB/TrEMBL
    A0A8L2R913, A6HFR6
    Related
    ENSRNOP00000080907.1, ENSRNOT00000102405.2
    Conserved Domains (3) summary
    pfam00870
    Location:93287
    P53; P53 DNA-binding domain
    pfam07710
    Location:317356
    P53_tetramer; P53 tetramerization motif
    pfam08563
    Location:527
    P53_TAD; P53 transactivation motif

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    54798871..54810300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008767773.4XP_008765995.1  cellular tumor antigen p53 isoform X2

    Related
    ENSRNOP00000047840.3, ENSRNOT00000046490.5
    Conserved Domains (3) summary
    pfam00870
    Location:93287
    P53; P53 DNA-binding domain
    pfam07710
    Location:317356
    P53_tetramer; P53 tetramerization motif
    pfam08563
    Location:527
    P53_TAD; P53 transactivation motif
  2. XM_017597018.3XP_017452507.1  cellular tumor antigen p53 isoform X2

    Conserved Domains (3) summary
    pfam00870
    Location:93287
    P53; P53 DNA-binding domain
    pfam07710
    Location:317356
    P53_tetramer; P53 tetramerization motif
    pfam08563
    Location:527
    P53_TAD; P53 transactivation motif
  3. XM_063268430.1XP_063124500.1  cellular tumor antigen p53 isoform X1

    Related
    ENSRNOP00000074031.3, ENSRNOT00000085115.3
  4. XM_063268429.1XP_063124499.1  cellular tumor antigen p53 isoform X1