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Tnf tumor necrosis factor [ Rattus norvegicus (Norway rat) ]

Gene ID: 24835, updated on 4-Sep-2021

Summary

Symbol
Tnfprovided by RGD
Full Name
tumor necrosis factorprovided by RGD
Primary source
RGD:3876
See related
Ensembl:ENSRNOG00000000837 Ensembl:ENSRNOG00000055156
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tnfa; RATTNF; TNF-alpha
Summary
acts as a cytokine; binds TNF receptors; plays a role in regulation of cell proliferation, induction of apoptosis, and inflammatory response [RGD, Feb 2006]
Expression
Biased expression in Thymus (RPKM 30.7), Spleen (RPKM 26.5) and 9 other tissues See more
Orthologs
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Genomic context

See Tnf in Genome Data Viewer
Location:
20p12
Exon count:
4
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (3622011..3624629)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (5189382..5192000, complement)

Chromosome 20 - NC_051355.1Genomic Context describing neighboring genes Neighboring gene ATPase H+ transporting V1 subunit G2 Neighboring gene NFKB inhibitor like 1 Neighboring gene lymphotoxin alpha Neighboring gene lymphotoxin beta Neighboring gene leukocyte specific transcript 1 Neighboring gene natural cytotoxicity triggering receptor 3

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC124630

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cytokine activity ISO
Inferred from Sequence Orthology
more info
 
enables cytokine activity TAS
Traceable Author Statement
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protease binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
 
enables tumor necrosis factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables tumor necrosis factor receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables tumor necrosis factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables tumor necrosis factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within JNK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in acute inflammatory response IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within animal organ morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell activation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular extravasation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to amino acid stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to amyloid-beta IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to interferon-gamma IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to molecule of bacterial origin IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to nicotine ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to retinoic acid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to toxic substance IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in chronic inflammatory response to antigenic stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in circadian rhythm IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cortical actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within defense response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within defense response to Gram-positive bacterium ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within defense response to bacterium ISO
Inferred from Sequence Orthology
more info
 
involved_in detection of mechanical stimulus involved in sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic digestive tract development ISO
Inferred from Sequence Orthology
more info
 
involved_in endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within epithelial cell proliferation involved in salivary gland morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within extracellular matrix organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in extrinsic apoptotic signaling pathway via death domain receptors IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
 
involved_in extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within glucose metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within humoral immune response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in inflammatory response TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within leukocyte migration ISO
Inferred from Sequence Orthology
more info
 
involved_in leukocyte migration involved in inflammatory response IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in leukocyte tethering or rolling ISO
Inferred from Sequence Orthology
more info
 
involved_in lipopolysaccharide-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in liver regeneration IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in microglial cell activation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within necroptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in necroptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in necroptotic signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of L-glutamate import across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of alkaline phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of amyloid-beta clearance ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of bicellular tight junction assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of bile acid secretion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of branching involved in lung morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cytokine production involved in immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of glucose import IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of glucose import ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of heart rate IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of lipid catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of myoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of myosin-light-chain-phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of oxidative phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of production of miRNAs involved in gene silencing by miRNA ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein-containing complex disassembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of negative regulation of signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of systemic arterial blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of vascular wound healing ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of I-kappaB phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of JUN kinase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within positive regulation of NIK/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NIK/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of action potential IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of amyloid-beta formation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of blood microparticle formation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of calcidiol 1-monooxygenase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of calcineurin-NFAT signaling cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of chemokine (C-X-C motif) ligand 2 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of chemokine production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of chronic inflammatory response to antigenic stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cytokine production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of positive regulation of cytokine production involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cytokine production involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of estradiol secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of extrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of fever generation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fractalkine production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of hair follicle development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of hepatocyte proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of hepatocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of humoral immune response mediated by circulating immunoglobulin ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of interferon-gamma production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-18 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of positive regulation of interleukin-33 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of leukocyte adhesion to arterial endothelial cell ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of leukocyte adhesion to vascular endothelial cell ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of membrane protein ectodomain proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitotic nuclear division IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neutrophil activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of nitric-oxide synthase activity IC
Inferred by Curator
more info
PubMed 
involved_in positive regulation of nitric-oxide synthase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of nitrogen compound metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of oxidative stress-induced neuron death IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phagocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of podosome assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of positive regulation of pri-miRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of programmed cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to cell surface ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein-containing complex disassembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of receptor signaling pathway via JAK-STAT IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of superoxide dismutase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of synoviocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of translational initiation by iron ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tyrosine phosphorylation of STAT protein IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of vascular associated smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vitamin D biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of branching involved in salivary gland morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of establishment of endothelial barrier ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of immunoglobulin production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of synapse organization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to 3,3',5-triiodo-L-thyronine IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to Gram-negative bacterium IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to activity IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to bacterium IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to glucocorticoid ISO
Inferred from Sequence Orthology
more info
 
involved_in response to gold nanoparticle IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to nutrient levels IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within response to organic substance ISO
Inferred from Sequence Orthology
more info
 
involved_in response to paracetamol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to radiation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to virus ISO
Inferred from Sequence Orthology
more info
 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in sequestering of triglyceride ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in skeletal muscle contraction IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in toll-like receptor 3 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in tumor necrosis factor-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in vascular endothelial growth factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in vascular endothelial growth factor production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in vasodilation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in phagocytic cup ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in recycling endosome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tumor necrosis factor
Names
cachectin
tumor necrosis factor (TNF superfamily, member 2)
tumor necrosis factor ligand superfamily member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012675.3NP_036807.1  tumor necrosis factor

    See identical proteins and their annotated locations for NP_036807.1

    Status: VALIDATED

    Source sequence(s)
    BX883046
    UniProtKB/Swiss-Prot
    P16599
    Related
    ENSRNOP00000074520.1, ENSRNOT00000079677.1
    Conserved Domains (1) summary
    pfam00229
    Location:105235
    TNF; TNF(tumor Necrosis Factor) family

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051355.1 Reference mRatBN7.2 Primary Assembly

    Range
    3622011..3624629
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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