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Tk1 thymidine kinase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24834, updated on 11-Apr-2024

Summary

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Official Symbol
Tk1provided by RGD
Official Full Name
thymidine kinase 1provided by RGD
Primary source
RGD:621014
See related
Ensembl:ENSRNOG00000047314 AllianceGenome:RGD:621014
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tk
Summary
Enables identical protein binding activity. Involved in several processes, including fetal process involved in parturition; response to cortisol; and thymidine metabolic process. Predicted to be located in cytoplasm. Orthologous to human TK1 (thymidine kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 260.9), Thymus (RPKM 147.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
10q32.2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (103533449..103544818, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (103034755..103046125, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (106817556..106828888, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene smilar to human chromosome 17 open reading frame 99 Neighboring gene U6 spliceosomal RNA Neighboring gene synaptogyrin 2 Neighboring gene arylformamidase Neighboring gene uncharacterized LOC102548046 Neighboring gene baculoviral IAP repeat-containing 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. HSV type 1 thymidine kinase protein accumulation in round spermatids induces male infertility by spermatogenesis disruption and apoptotic loss of germ cells. Cai LY, et al. Reprod Toxicol, 2009 Jan. PMID 19063959
  2. Thymidine kinase 1 as a molecular target for boron neutron capture therapy of brain tumors. Barth RF, et al. Proc Natl Acad Sci U S A, 2008 Nov 11. PMID 18981415, Free PMC Article
  3. Serum thymidine kinase 1 is a prognostic and monitoring factor in patients with non-small cell lung cancer. Li HX, et al. Oncol Rep, 2005 Jan. PMID 15583816
  4. The clinical significance of thymidine kinase 1 measurement in serum of breast cancer patients using anti-TK1 antibody. He Q, et al. Int J Biol Markers, 2000 Apr-Jun. PMID 10883887
  5. The ontogeny of thymidine kinase in tissues of man and rat. Herzfeld A, et al. Pediatr Res, 1980 Dec. PMID 7208144

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A cytosolic form of TK2 was identified in all tested tissues in addition to mitochondrial TK2. TK1 was detected in liver and spleen cytosolic extracts while dCK was found in liver, spleen and lung cytosolic extracts.
    Title: Tissue specific distribution of pyrimidine deoxynucleoside salvage enzymes shed light on the mechanism of mitochondrial DNA depletion.
  2. These results suggest that the expression of HSV1-TK in testes brings about not only abnormal spermiogenesis but also a loss of germ cells due to apoptosis.
    Title: HSV type 1 thymidine kinase protein accumulation in round spermatids induces male infertility by spermatogenesis disruption and apoptotic loss of germ cells.
  3. Thymidine kinase 1 is a molecular target for boron neutron capture therapy of brain tumors.
    Title: Thymidine kinase 1 as a molecular target for boron neutron capture therapy of brain tumors.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables thymidine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables thymidine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables thymidine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA synthesis involved in mitotic DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in deoxyribonucleoside monophosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within deoxyribonucleoside monophosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in digestive tract development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in fetal process involved in parturition IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in liver development IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within nucleotide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein homotetramerization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein homotetramerization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to copper ion IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to cortisol IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to nutrient levels IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to toxic substance IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in skeletal muscle cell proliferation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in thymidine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in thymidine metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in thymidine metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
thymidine kinase, cytosolic
Names
thymidine kinase 1, soluble
NP_434687.1
XP_017452506.1
XP_038941153.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_052800.1 → NP_434687.1  thymidine kinase, cytosolic

    See identical proteins and their annotated locations for NP_434687.1

    Status: VALIDATED

    Source sequence(s)
    AW919734, BF547747, BP495650, CK471539, CV072953, EV770793, M22642
    UniProtKB/TrEMBL
    A6HL31, M0RCX2
    Related
    ENSRNOP00000088672.1, ENSRNOT00000098570.1
    Conserved Domains (1) summary
    cl23762
    Location:18 → 197
    TK; Thymidine kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    103533449..103544818 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017597017.3 → XP_017452506.1  thymidine kinase, cytosolic isoform X1

    UniProtKB/TrEMBL
    A6HL32, M0RCX2
    Related
    ENSRNOP00000067459.2
    Conserved Domains (1) summary
    cl23762
    Location:1 → 161
    TK; Thymidine kinase

  2. XM_039085225.2 → XP_038941153.1  thymidine kinase, cytosolic isoform X2

    Conserved Domains (1) summary
    cl23762
    Location:18 → 70
    TK; Thymidine kinase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P27158.1 GenPept UniProtKB/Swiss-Prot:P27158

Gene LinkOut

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