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Thy1 Thy-1 cell surface antigen [ Rattus norvegicus (Norway rat) ]

Gene ID: 24832, updated on 5-Mar-2024

Summary

Official Symbol
Thy1provided by RGD
Official Full Name
Thy-1 cell surface antigenprovided by RGD
Primary source
RGD:3860
See related
Ensembl:ENSRNOG00000006604 AllianceGenome:RGD:3860
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CD7
Summary
Enables GPI anchor binding activity; GTPase activator activity; and protein kinase binding activity. Involved in several processes, including T cell receptor signaling pathway; focal adhesion assembly; and negative regulation of neuron projection development. Located in several cellular components, including growth cone; neuron projection membrane; and neuronal cell body membrane. Is anchored component of plasma membrane. Biomarker of retinal disease and retinal ischemia. Orthologous to human THY1 (Thy-1 cell surface antigen). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 2242.5) and Brain (RPKM 1279.6) See more
Orthologs
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Genomic context

See Thy1 in Genome Data Viewer
Location:
8q22
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (53286396..53291541)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (44389495..44394688)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (48382121..48387271)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108351689 Neighboring gene uncharacterized LOC134480042 Neighboring gene ubiquitin specific peptidase 2 Neighboring gene membrane frizzled-related protein

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GPI anchor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables integrin binding IEA
Inferred from Electronic Annotation
more info
 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
 
enables integrin binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in T cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within_positive_effect cell-cell signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell-cell signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in focal adhesion assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in heterotypic cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in integrin-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in mast cell activation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of T cell receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of axonogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of fibroblast proliferation NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within_positive_effect negative regulation of neuron projection regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neuron projection regeneration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T cell activation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cellular extravasation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cellular extravasation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of focal adhesion assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of focal adhesion assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of focal adhesion assembly ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of peptidyl-tyrosine phosphorylation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of release of sequestered calcium ion into cytosol IDA
Inferred from Direct Assay
more info
PubMed 
involved_in receptor clustering IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in response to axon injury IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in retinal cone cell development ISO
Inferred from Sequence Orthology
more info
 
involved_in retinal cone cell development ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in axolemma IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface TAS
Traceable Author Statement
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in growth cone IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in membrane raft IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
thy-1 membrane glycoprotein
Names
CD90
Thy-1 protein
Thymus cell surface antigen
thy-1 antigen
thy-1 glycoprotein
thymus cell antigen 1, theta
NP_036805.1
XP_017450965.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012673.2NP_036805.1  thy-1 membrane glycoprotein preproprotein

    See identical proteins and their annotated locations for NP_036805.1

    Status: VALIDATED

    Source sequence(s)
    CB741211, CB797376, CO561977, X03150
    UniProtKB/Swiss-Prot
    P01830
    UniProtKB/TrEMBL
    A0A8I5ZPP2, A6J3U9, A6J3V0
    Conserved Domains (2) summary
    cd00096
    Location:3340
    Ig; Ig strand B [structural motif]
    cl11960
    Location:24122
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    53286396..53291541
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017595476.2XP_017450965.1  thy-1 membrane glycoprotein isoform X1

    UniProtKB/TrEMBL
    A0A8L2Q3U4
    Related
    ENSRNOP00000008685.2