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Thy1 Thy-1 cell surface antigen [ Rattus norvegicus (Norway rat) ]

Gene ID: 24832, updated on 17-Oct-2021

Summary

Official Symbol
Thy1provided by RGD
Official Full Name
Thy-1 cell surface antigenprovided by RGD
Primary source
RGD:3860
See related
EnsemblRapid:ENSRNOG00000006604
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CD7
Summary
cell surface glycoprotein antigen [RGD, Feb 2006]
Expression
Biased expression in Thymus (RPKM 2242.5) and Brain (RPKM 1279.6) See more
Orthologs
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Genomic context

See Thy1 in Genome Data Viewer
Location:
8q22
Exon count:
6
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (44389495..44394688)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (48382121..48387271)

Chromosome 8 - NC_051343.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC108351689 Neighboring gene ubiquitin specific peptidase 2 Neighboring gene membrane frizzled-related protein

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GPI anchor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GPI anchor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
 
enables integrin binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in T cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell-cell signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell-cell signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in focal adhesion assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in focal adhesion assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in integrin-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in mast cell activation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of T cell receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of axonogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of fibroblast proliferation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of neuron projection regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neuron projection regeneration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of T cell activation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cellular extravasation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of focal adhesion assembly ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-tyrosine phosphorylation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of release of sequestered calcium ion into cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of release of sequestered calcium ion into cytosol IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in receptor clustering IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of Rho-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of Rho-dependent protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in regulation of cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in retinal cone cell development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in retinal cone cell development ISO
Inferred from Sequence Orthology
more info
 
involved_in retinal cone cell development ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in anchored component of external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in anchored component of external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in anchored component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in axolemma IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface TAS
Traceable Author Statement
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in growth cone IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in membrane raft IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
thy-1 membrane glycoprotein
Names
CD90
Thy-1 protein
Thymus cell surface antigen
thy-1 antigen
thy-1 glycoprotein
thymus cell antigen 1, theta

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012673.2NP_036805.1  thy-1 membrane glycoprotein preproprotein

    See identical proteins and their annotated locations for NP_036805.1

    Status: VALIDATED

    Source sequence(s)
    CB741211, CB797376, CO561977, X03150
    UniProtKB/Swiss-Prot
    P01830
    Conserved Domains (2) summary
    cd00096
    Location:3340
    Ig; Ig strand B [structural motif]
    cl11960
    Location:24122
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051343.1 Reference mRatBN7.2 Primary Assembly

    Range
    44389495..44394688
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039080838.1XP_038936766.1  thy-1 membrane glycoprotein isoform X4

    Conserved Domains (2) summary
    cd00096
    Location:1825
    Ig; Ig strand B [structural motif]
    cl11960
    Location:9107
    Ig; Immunoglobulin domain
  2. XM_039080836.1XP_038936764.1  thy-1 membrane glycoprotein isoform X4

    Conserved Domains (2) summary
    cd00096
    Location:1825
    Ig; Ig strand B [structural motif]
    cl11960
    Location:9107
    Ig; Immunoglobulin domain
  3. XM_039080834.1XP_038936762.1  thy-1 membrane glycoprotein isoform X1

    Conserved Domains (2) summary
    cd00096
    Location:136143
    Ig; Ig strand B [structural motif]
    cl11960
    Location:127225
    Ig; Immunoglobulin domain
  4. XM_017595476.1XP_017450965.1  thy-1 membrane glycoprotein isoform X2

    Related
    ENSRNOP00000008685.2, ENSRNOT00000008685.4
  5. XM_039080837.1XP_038936765.1  thy-1 membrane glycoprotein isoform X4

    Conserved Domains (2) summary
    cd00096
    Location:1825
    Ig; Ig strand B [structural motif]
    cl11960
    Location:9107
    Ig; Immunoglobulin domain
  6. XM_039080835.1XP_038936763.1  thy-1 membrane glycoprotein isoform X3

    Related
    ENSRNOP00000079974.1, ENSRNOT00000095277.1
    Conserved Domains (2) summary
    cd00096
    Location:3340
    Ig; Ig strand B [structural motif]
    cl11960
    Location:24122
    Ig; Immunoglobulin domain
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