Thrb thyroid hormone receptor beta [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Thrbprovided by RGD
Official Full Name: thyroid hormone receptor betaprovided by RGD
Primary source: RGD:3858
See related: Ensembl:ENSRNOG00000006649 AllianceGenome:RGD:3858
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ERBA2; Nr1a2; T3rec; TRbeta; RATT3REC; c-erbA-2; C-erba-beta
Summary: Enables double-stranded DNA binding activity; identical protein binding activity; and nuclear receptor activity. Involved in several processes, including positive regulation of chondrocyte differentiation; positive regulation of ossification; and regulation of lipid metabolic process. Predicted to be located in nuclear body. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Used to study breast cancer. Human ortholog(s) of this gene implicated in several diseases, including cervix uteri carcinoma in situ; prostate cancer; renal cell carcinoma; selective pituitary thyroid hormone resistance; and thyroid hormone resistance syndrome. Orthologous to human THRB (thyroid hormone receptor beta). [provided by Alliance of Genome Resources, May 2025]
Expression: Biased expression in Kidney (RPKM 121.4), Heart (RPKM 107.7) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p16

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (10115954..10465231, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (7685180..8031920, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (8890578..9239815, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Molecular modeling and molecular dynamics simulation studies on thyroid hormone receptor from Rattus norvegicus: role of conserved water molecules.
Title: Molecular modeling and molecular dynamics simulation studies on thyroid hormone receptor from Rattus norvegicus: role of conserved water molecules.
Thyroid Hormone Signaling in Embryonic Stem Cells: Crosstalk with the Retinoic Acid Pathway.
Title: Thyroid Hormone Signaling in Embryonic Stem Cells: Crosstalk with the Retinoic Acid Pathway.
This study demonstrated that Thyroid receptor beta involvement in the effects of acute nicotine on hippocampus-dependent memory
Title: Thyroid receptor β involvement in the effects of acute nicotine on hippocampus-dependent memory.
down-regulated in hepatocellular carcinoma
Title: Local hypothyroidism favors the progression of preneoplastic lesions to hepatocellular carcinoma in rats.
a novel inverse recruitment mechanism in which liganded TRbeta recruits corepressors to inhibit PLA2g2a expression.
Title: Nuclear corepressors mediate the repression of phospholipase A2 group IIa gene transcription by thyroid hormone.
role for TRalpha1 in the regulation of hypothalamic TRH mRNA expression, whereas TRbeta plays a dominant role in pituitary and liver thyroid hormone metabolism.
Title: Action of specific thyroid hormone receptor α(1) and β(1) antagonists in the central and peripheral regulation of thyroid hormone metabolism in the rat.
Although systemic administration of thrb agonist increases energy expenditure and induces further weight loss in STZ-diabetic rats, it neither increased brown adipose tissue glucose uptake nor attenuated diabetic hyperglycemia.
Title: In uncontrolled diabetes, thyroid hormone and sympathetic activators induce thermogenesis without increasing glucose uptake in brown adipose tissue.
Protein-disulfide isomerase regulates the thyroid hormone receptor-mediated gene expression via redox factor-1 through thiol reduction-oxidation.
Title: Protein-disulfide isomerase regulates the thyroid hormone receptor-mediated gene expression via redox factor-1 through thiol reduction-oxidation.
conjugation of SUMO to TR has a TR-isoform preference and is important for T3-dependent gene induction and repression.
Title: Thyroid hormone receptor isoform-specific modification by small ubiquitin-like modifier (SUMO) modulates thyroid hormone-dependent gene regulation.
ligand-binding domain ofthyroid hormone receptor-beta2 in recruiting different coactivators to the receptor[thyroid hormone receptor-beta2]
Title: The N-Terminal A/B domain of the thyroid hormone receptor-beta2 isoform influences ligand-dependent recruitment of coactivators to the ligand-binding domain.

Submit: New GeneRIF Correction See all GeneRIFs (29)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

d15rat76 (e-PCR)
- UniSTS:121094

BF399305 (e-PCR)
- UniSTS:247635

BE119389 (e-PCR)
- UniSTS:249177

Thrb (e-PCR), detects polymorphism
- UniSTS:463228

RH132907 (e-PCR)
- UniSTS:216190

D15Wox5 (e-PCR)
- UniSTS:517825

PMC27204P1 (e-PCR)
- UniSTS:272380

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin DNA binding	IEA Inferred from Electronic Annotation more info
enables chromatin DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables enzyme binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables nuclear receptor activity	IEA Inferred from Electronic Annotation more info
enables nuclear receptor activity	ISO Inferred from Sequence Orthology more info
enables nuclear receptor activity	TAS Traceable Author Statement more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables thyroid hormone binding	IEA Inferred from Electronic Annotation more info
enables thyroid hormone binding	ISO Inferred from Sequence Orthology more info
enables thyroid hormone binding	ISS Inferred from Sequence or Structural Similarity more info
enables transcription coactivator binding	IEA Inferred from Electronic Annotation more info
enables transcription coactivator binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within animal organ morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to thyroid hormone stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to thyroid hormone stimulus	ISO Inferred from Sequence Orthology more info
involved_in embryonic organ development	IEP Inferred from Expression Pattern more info	PubMed
involved_in female courtship behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within female courtship behavior	ISO Inferred from Sequence Orthology more info
involved_in intracellular receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in mRNA transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in mRNA transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of female receptivity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of female receptivity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of chondrocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of ossification	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of thyroid hormone receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of thyroid hormone receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of cholesterol metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of heart contraction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of heart contraction	ISO Inferred from Sequence Orthology more info
involved_in regulation of lipid metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of triglyceride metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retinal cone cell apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within retinal cone cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in retinal cone cell development	IEA Inferred from Electronic Annotation more info
acts_upstream_of retinal cone cell development	ISO Inferred from Sequence Orthology more info
involved_in retinoic acid receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory perception of sound	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sensory perception of sound	ISO Inferred from Sequence Orthology more info
involved_in thyroid hormone receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in type I pneumocyte differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within type I pneumocyte differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RNA polymerase II transcription regulator complex	IEA Inferred from Electronic Annotation more info
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: thyroid hormone receptor beta

Names: TRbeta2Delta; nuclear receptor subfamily 1 group A member 2; thyroid hormone receptor beta 3; thyroid hormone receptor beta2delta; thyroid hormone receptor, beta (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 2)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001270854.1 → NP_001257783.1 thyroid hormone receptor beta isoform 2

See identical proteins and their annotated locations for NP_001257783.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

JAXUCZ010000015

UniProtKB/Swiss-Prot

P18113, P37826

UniProtKB/TrEMBL

A6K040, F1LP32, F1LQ07

Conserved Domains (2) summary

cd06935
Location:216 → 458

NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors

cd06961
Location:106 → 192

NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
NM_012672.3 → NP_036804.2 thyroid hormone receptor beta isoform 1

See identical proteins and their annotated locations for NP_036804.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

JAXUCZ010000015

UniProtKB/TrEMBL

D3ZGG0, D7R7X1, Q3HW36

Conserved Domains (2) summary

cd06935
Location:252 → 494

NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors

cd06961
Location:106 → 228

NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

10115954..10465231 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063273969.1 → XP_063130039.1 thyroid hormone receptor beta isoform X1

UniProtKB/Swiss-Prot

P18113, P37826

UniProtKB/TrEMBL

A6K040, F1LP32, F1LQ07
XM_063273981.1 → XP_063130051.1 thyroid hormone receptor beta isoform X1

UniProtKB/Swiss-Prot

P18113, P37826

UniProtKB/TrEMBL

A6K040, F1LP32, F1LQ07
XM_063273982.1 → XP_063130052.1 thyroid hormone receptor beta isoform X1

UniProtKB/Swiss-Prot

P18113, P37826

UniProtKB/TrEMBL

A6K040, F1LP32, F1LQ07
XM_063273979.1 → XP_063130049.1 thyroid hormone receptor beta isoform X1

UniProtKB/Swiss-Prot

P18113, P37826

UniProtKB/TrEMBL

A6K040, F1LP32, F1LQ07
XM_063273971.1 → XP_063130041.1 thyroid hormone receptor beta isoform X1

UniProtKB/Swiss-Prot

P18113, P37826

UniProtKB/TrEMBL

A6K040, F1LP32, F1LQ07
XM_063273974.1 → XP_063130044.1 thyroid hormone receptor beta isoform X1

UniProtKB/Swiss-Prot

P18113, P37826

UniProtKB/TrEMBL

A6K040, F1LP32, F1LQ07
XM_063273975.1 → XP_063130045.1 thyroid hormone receptor beta isoform X1

UniProtKB/Swiss-Prot

P18113, P37826

UniProtKB/TrEMBL

A6K040, F1LP32, F1LQ07
XM_063273972.1 → XP_063130042.1 thyroid hormone receptor beta isoform X1

UniProtKB/Swiss-Prot

P18113, P37826

UniProtKB/TrEMBL

A6K040, F1LP32, F1LQ07
XM_063273976.1 → XP_063130046.1 thyroid hormone receptor beta isoform X1

UniProtKB/Swiss-Prot

P18113, P37826

UniProtKB/TrEMBL

A6K040, F1LP32, F1LQ07
XM_063273978.1 → XP_063130048.1 thyroid hormone receptor beta isoform X1

UniProtKB/Swiss-Prot

P18113, P37826

UniProtKB/TrEMBL

A6K040, F1LP32, F1LQ07
XM_063273970.1 → XP_063130040.1 thyroid hormone receptor beta isoform X1

UniProtKB/Swiss-Prot

P18113, P37826

UniProtKB/TrEMBL

A6K040, F1LP32, F1LQ07

Related

ENSRNOP00000008989.2, ENSRNOT00000008989.8
XM_063273980.1 → XP_063130050.1 thyroid hormone receptor beta isoform X1

UniProtKB/Swiss-Prot

P18113, P37826

UniProtKB/TrEMBL

A6K040, F1LP32, F1LQ07
XM_039092997.2 → XP_038948925.1 thyroid hormone receptor beta isoform X1

UniProtKB/Swiss-Prot

P18113, P37826

UniProtKB/TrEMBL

A6K040, F1LP32, F1LQ07

Conserved Domains (2) summary

cd06935
Location:216 → 458

NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors

cd06961
Location:106 → 192

NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
XM_063273984.1 → XP_063130054.1 thyroid hormone receptor beta isoform X1

UniProtKB/Swiss-Prot

P18113, P37826

UniProtKB/TrEMBL

A6K040, F1LP32, F1LQ07

Related

ENSRNOP00000058119.6, ENSRNOT00000061402.8
XM_039092998.2 → XP_038948926.1 thyroid hormone receptor beta isoform X2

Conserved Domains (2) summary

cd06935
Location:129 → 371

NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors

cd06961
Location:19 → 105

NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
XM_063273988.1 → XP_063130058.1 thyroid hormone receptor beta isoform X2
XM_063273985.1 → XP_063130055.1 thyroid hormone receptor beta isoform X1

UniProtKB/Swiss-Prot

P18113, P37826

UniProtKB/TrEMBL

A6K040, F1LP32, F1LQ07
XM_063273989.1 → XP_063130059.1 thyroid hormone receptor beta isoform X2
XM_063273986.1 → XP_063130056.1 thyroid hormone receptor beta isoform X1

UniProtKB/Swiss-Prot

P18113, P37826

UniProtKB/TrEMBL

A6K040, F1LP32, F1LQ07
XM_063273973.1 → XP_063130043.1 thyroid hormone receptor beta isoform X1

UniProtKB/Swiss-Prot

P18113, P37826

UniProtKB/TrEMBL

A6K040, F1LP32, F1LQ07
XM_063273983.1 → XP_063130053.1 thyroid hormone receptor beta isoform X1

UniProtKB/Swiss-Prot

P18113, P37826

UniProtKB/TrEMBL

A6K040, F1LP32, F1LQ07
XM_063273990.1 → XP_063130060.1 thyroid hormone receptor beta isoform X4

UniProtKB/TrEMBL

D3ZGG0, D7R7X1, Q3HW36
XM_006251709.4 → XP_006251771.1 thyroid hormone receptor beta isoform X3

See identical proteins and their annotated locations for XP_006251771.1

UniProtKB/TrEMBL

A0A8I5ZV63, A6K042

Related

ENSRNOP00000082752.2, ENSRNOT00000114169.2

Conserved Domains (2) summary

cd06935
Location:269 → 511

NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors

cd06961
Location:159 → 245

NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers