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Thrb thyroid hormone receptor beta [ Rattus norvegicus (Norway rat) ]

Gene ID: 24831, updated on 30-Jul-2025
Official Symbol
Thrbprovided by RGD
Official Full Name
thyroid hormone receptor betaprovided by RGD
Primary source
RGD:3858
See related
Ensembl:ENSRNOG00000006649 AllianceGenome:RGD:3858
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
ERBA2; Nr1a2; T3rec; TRbeta; RATT3REC; c-erbA-2; C-erba-beta
Summary
Enables double-stranded DNA binding activity; identical protein binding activity; and nuclear receptor activity. Involved in several processes, including positive regulation of chondrocyte differentiation; positive regulation of ossification; and regulation of lipid metabolic process. Predicted to be located in nuclear body. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Used to study breast cancer. Human ortholog(s) of this gene implicated in several diseases, including cervix uteri carcinoma in situ; prostate cancer; renal cell carcinoma; selective pituitary thyroid hormone resistance; and thyroid hormone resistance syndrome. Orthologous to human THRB (thyroid hormone receptor beta). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Kidney (RPKM 121.4), Heart (RPKM 107.7) and 8 other tissues See more
Orthologs
human mouse all
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See Thrb in Genome Data Viewer
Location:
15p16
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (10115954..10465231, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (7685180..8031920, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (8890578..9239815, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene nuclear receptor subfamily 1, group D, member 2 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase like 7 Neighboring gene uncharacterized LOC120096915 Neighboring gene uncharacterized LOC120096913 Neighboring gene uncharacterized LOC120096912 Neighboring gene eukaryotic translation initiation factor 1, pseudogene 2 Neighboring gene uncharacterized LOC134482082 Neighboring gene uncharacterized LOC134482083 Neighboring gene biorientation of chromosomes in cell division 1, pseudogene 1 Neighboring gene uncharacterized LOC120096914 Neighboring gene uncharacterized LOC108352884 Neighboring gene polypyrimidine tract binding protein 1, pseudogene 1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Molecular modeling and molecular dynamics simulation studies on thyroid hormone receptor from Rattus norvegicus: role of conserved water molecules. Mukherjee S, et al. J Mol Model, 2021 Apr 8. PMID 33834296
  2. Targeting thyroid hormone receptor-beta agonists to the liver reduces cholesterol and triglycerides and improves the therapeutic index. Erion MD, et al. Proc Natl Acad Sci U S A, 2007 Sep 25. PMID 17878314, Free PMC Article
  3. The rat thyroid hormone receptor (TR) Deltabeta3 displays cell-, TR isoform-, and thyroid hormone response element-specific actions. Harvey CB, et al. Endocrinology, 2007 Apr. PMID 17218414, Free PMC Article
  4. Microsatellite analysis of allelic imbalance in tumour and blood from patients with prostate cancer. Schwarzenbach H, et al. BJU Int, 2008 Jul. PMID 18336598
  5. The N-Terminal A/B domain of the thyroid hormone receptor-beta2 isoform influences ligand-dependent recruitment of coactivators to the ligand-binding domain. Tian H, et al. Mol Endocrinol, 2006 Sep. PMID 16645037

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Molecular modeling and molecular dynamics simulation studies on thyroid hormone receptor from Rattus norvegicus: role of conserved water molecules.
    Title: Molecular modeling and molecular dynamics simulation studies on thyroid hormone receptor from Rattus norvegicus: role of conserved water molecules.
  2. Thyroid Hormone Signaling in Embryonic Stem Cells: Crosstalk with the Retinoic Acid Pathway.
    Title: Thyroid Hormone Signaling in Embryonic Stem Cells: Crosstalk with the Retinoic Acid Pathway.
  3. This study demonstrated that Thyroid receptor beta involvement in the effects of acute nicotine on hippocampus-dependent memory
    Title: Thyroid receptor β involvement in the effects of acute nicotine on hippocampus-dependent memory.
  4. down-regulated in hepatocellular carcinoma
    Title: Local hypothyroidism favors the progression of preneoplastic lesions to hepatocellular carcinoma in rats.
  5. a novel inverse recruitment mechanism in which liganded TRbeta recruits corepressors to inhibit PLA2g2a expression.
    Title: Nuclear corepressors mediate the repression of phospholipase A2 group IIa gene transcription by thyroid hormone.
  6. role for TRalpha1 in the regulation of hypothalamic TRH mRNA expression, whereas TRbeta plays a dominant role in pituitary and liver thyroid hormone metabolism.
    Title: Action of specific thyroid hormone receptor α(1) and β(1) antagonists in the central and peripheral regulation of thyroid hormone metabolism in the rat.
  7. Although systemic administration of thrb agonist increases energy expenditure and induces further weight loss in STZ-diabetic rats, it neither increased brown adipose tissue glucose uptake nor attenuated diabetic hyperglycemia.
    Title: In uncontrolled diabetes, thyroid hormone and sympathetic activators induce thermogenesis without increasing glucose uptake in brown adipose tissue.
  8. Protein-disulfide isomerase regulates the thyroid hormone receptor-mediated gene expression via redox factor-1 through thiol reduction-oxidation.
    Title: Protein-disulfide isomerase regulates the thyroid hormone receptor-mediated gene expression via redox factor-1 through thiol reduction-oxidation.
  9. conjugation of SUMO to TR has a TR-isoform preference and is important for T3-dependent gene induction and repression.
    Title: Thyroid hormone receptor isoform-specific modification by small ubiquitin-like modifier (SUMO) modulates thyroid hormone-dependent gene regulation.
  10. ligand-binding domain ofthyroid hormone receptor-beta2 in recruiting different coactivators to the receptor[thyroid hormone receptor-beta2]
    Title: The N-Terminal A/B domain of the thyroid hormone receptor-beta2 isoform influences ligand-dependent recruitment of coactivators to the ligand-binding domain.
Submit: New GeneRIF Correction See all GeneRIFs (29)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables nuclear receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables nuclear receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables thyroid hormone binding ISO
Inferred from Sequence Orthology
more info
  
enables thyroid hormone binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables transcription coactivator binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within animal organ morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to thyroid hormone stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in embryonic organ development IEA
Inferred from Electronic Annotation
more info
  
involved_in embryonic organ development IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within female courtship behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of female receptivity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of chondrocyte differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of ossification IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of thyroid hormone receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cholesterol metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of heart contraction ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of lipid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of triglyceride metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within retinal cone cell apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of retinal cone cell development ISO
Inferred from Sequence Orthology
more info
  
involved_in retinoic acid receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within sensory perception of sound ISO
Inferred from Sequence Orthology
more info
  
involved_in thyroid hormone receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within type I pneumocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
thyroid hormone receptor beta
Names
TRbeta2Delta
nuclear receptor subfamily 1 group A member 2
thyroid hormone receptor beta 3
thyroid hormone receptor beta2delta
thyroid hormone receptor, beta (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 2)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270854.1 → NP_001257783.1  thyroid hormone receptor beta isoform 2

    See identical proteins and their annotated locations for NP_001257783.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/Swiss-Prot
    P18113, P37826
    UniProtKB/TrEMBL
    A6K040, F1LP32, F1LQ07
    Conserved Domains (2) summary
    cd06935
    Location:216 → 458
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:106 → 192
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

  2. NM_012672.3 → NP_036804.2  thyroid hormone receptor beta isoform 1

    See identical proteins and their annotated locations for NP_036804.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    D3ZGG0, D7R7X1, Q3HW36
    Conserved Domains (2) summary
    cd06935
    Location:252 → 494
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:106 → 228
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    10115954..10465231 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063273969.1 → XP_063130039.1  thyroid hormone receptor beta isoform X1

    UniProtKB/Swiss-Prot
    P18113, P37826
    UniProtKB/TrEMBL
    A6K040, F1LP32, F1LQ07

  2. XM_063273981.1 → XP_063130051.1  thyroid hormone receptor beta isoform X1

    UniProtKB/Swiss-Prot
    P18113, P37826
    UniProtKB/TrEMBL
    A6K040, F1LP32, F1LQ07

  3. XM_063273982.1 → XP_063130052.1  thyroid hormone receptor beta isoform X1

    UniProtKB/Swiss-Prot
    P18113, P37826
    UniProtKB/TrEMBL
    A6K040, F1LP32, F1LQ07

  4. XM_063273979.1 → XP_063130049.1  thyroid hormone receptor beta isoform X1

    UniProtKB/Swiss-Prot
    P18113, P37826
    UniProtKB/TrEMBL
    A6K040, F1LP32, F1LQ07

  5. XM_063273971.1 → XP_063130041.1  thyroid hormone receptor beta isoform X1

    UniProtKB/Swiss-Prot
    P18113, P37826
    UniProtKB/TrEMBL
    A6K040, F1LP32, F1LQ07

  6. XM_063273974.1 → XP_063130044.1  thyroid hormone receptor beta isoform X1

    UniProtKB/Swiss-Prot
    P18113, P37826
    UniProtKB/TrEMBL
    A6K040, F1LP32, F1LQ07

  7. XM_063273975.1 → XP_063130045.1  thyroid hormone receptor beta isoform X1

    UniProtKB/Swiss-Prot
    P18113, P37826
    UniProtKB/TrEMBL
    A6K040, F1LP32, F1LQ07

  8. XM_063273972.1 → XP_063130042.1  thyroid hormone receptor beta isoform X1

    UniProtKB/Swiss-Prot
    P18113, P37826
    UniProtKB/TrEMBL
    A6K040, F1LP32, F1LQ07

  9. XM_063273976.1 → XP_063130046.1  thyroid hormone receptor beta isoform X1

    UniProtKB/Swiss-Prot
    P18113, P37826
    UniProtKB/TrEMBL
    A6K040, F1LP32, F1LQ07

  10. XM_063273978.1 → XP_063130048.1  thyroid hormone receptor beta isoform X1

    UniProtKB/Swiss-Prot
    P18113, P37826
    UniProtKB/TrEMBL
    A6K040, F1LP32, F1LQ07

  11. XM_063273970.1 → XP_063130040.1  thyroid hormone receptor beta isoform X1

    UniProtKB/Swiss-Prot
    P18113, P37826
    UniProtKB/TrEMBL
    A6K040, F1LP32, F1LQ07
    Related
    ENSRNOP00000008989.2, ENSRNOT00000008989.8

  12. XM_063273980.1 → XP_063130050.1  thyroid hormone receptor beta isoform X1

    UniProtKB/Swiss-Prot
    P18113, P37826
    UniProtKB/TrEMBL
    A6K040, F1LP32, F1LQ07

  13. XM_039092997.2 → XP_038948925.1  thyroid hormone receptor beta isoform X1

    UniProtKB/Swiss-Prot
    P18113, P37826
    UniProtKB/TrEMBL
    A6K040, F1LP32, F1LQ07
    Conserved Domains (2) summary
    cd06935
    Location:216 → 458
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:106 → 192
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

  14. XM_063273984.1 → XP_063130054.1  thyroid hormone receptor beta isoform X1

    UniProtKB/Swiss-Prot
    P18113, P37826
    UniProtKB/TrEMBL
    A6K040, F1LP32, F1LQ07
    Related
    ENSRNOP00000058119.6, ENSRNOT00000061402.8

  15. XM_039092998.2 → XP_038948926.1  thyroid hormone receptor beta isoform X2

    Conserved Domains (2) summary
    cd06935
    Location:129 → 371
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:19 → 105
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

  16. XM_063273988.1 → XP_063130058.1  thyroid hormone receptor beta isoform X2

  17. XM_063273985.1 → XP_063130055.1  thyroid hormone receptor beta isoform X1

    UniProtKB/Swiss-Prot
    P18113, P37826
    UniProtKB/TrEMBL
    A6K040, F1LP32, F1LQ07

  18. XM_063273989.1 → XP_063130059.1  thyroid hormone receptor beta isoform X2

  19. XM_063273986.1 → XP_063130056.1  thyroid hormone receptor beta isoform X1

    UniProtKB/Swiss-Prot
    P18113, P37826
    UniProtKB/TrEMBL
    A6K040, F1LP32, F1LQ07

  20. XM_063273973.1 → XP_063130043.1  thyroid hormone receptor beta isoform X1

    UniProtKB/Swiss-Prot
    P18113, P37826
    UniProtKB/TrEMBL
    A6K040, F1LP32, F1LQ07

  21. XM_063273983.1 → XP_063130053.1  thyroid hormone receptor beta isoform X1

    UniProtKB/Swiss-Prot
    P18113, P37826
    UniProtKB/TrEMBL
    A6K040, F1LP32, F1LQ07

  22. XM_063273990.1 → XP_063130060.1  thyroid hormone receptor beta isoform X4

    UniProtKB/TrEMBL
    D3ZGG0, D7R7X1, Q3HW36

  23. XM_006251709.4 → XP_006251771.1  thyroid hormone receptor beta isoform X3

    See identical proteins and their annotated locations for XP_006251771.1

    UniProtKB/TrEMBL
    A0A8I5ZV63, A6K042
    Related
    ENSRNOP00000082752.2, ENSRNOT00000114169.2
    Conserved Domains (2) summary
    cd06935
    Location:269 → 511
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:159 → 245
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P18113.2 GenPept UniProtKB/Swiss-Prot:P18113

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