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Tf transferrin [ Rattus norvegicus (Norway rat) ]

Gene ID: 24825, updated on 5-Sep-2025
Official Symbol
Tfprovided by RGD
Official Full Name
transferrinprovided by RGD
Primary source
RGD:3845
See related
Ensembl:ENSRNOG00000030625 AllianceGenome:RGD:3845
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tfn; Trf
Summary
Enables ferric iron binding activity. Involved in several processes, including cellular response to cAMP; cellular response to follicle-stimulating hormone stimulus; and regulation of nervous system development. Located in several cellular components, including basement membrane; cell tip; and dendrite. Used to study hepatitis. Biomarker of anemia and obesity. Human ortholog(s) of this gene implicated in anemia (multiple); atransferrinemia; gastrointestinal system disease; glucose metabolism disease (multiple); and restless legs syndrome. Orthologous to human TF (transferrin). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Restricted expression toward (RPKM 154751.8) See more
Orthologs
human mouse all
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Location:
8q32
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (112668667..112695376, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (103789780..103816487, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (111694570..111721275, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene RAB6B, member RAS oncogene family Neighboring gene uncharacterized LOC134480222 Neighboring gene SRP receptor subunit beta Neighboring gene uncharacterized LOC134480223 Neighboring gene uncharacterized LOC134480224 Neighboring gene uncharacterized LOC120094247 Neighboring gene inhibitor of carbonic anhydrase

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Remyelination after cuprizone-induced demyelination in the rat is stimulated by apotransferrin. Adamo AM, et al. Exp Neurol, 2006 Apr. PMID 16480980
  2. Changes in serum parameters associated with iron metabolism in male rat exposed to lead. Moshtaghie M, et al. J Physiol Biochem, 2013 Jun. PMID 23007736
  3. Intranasal administration of aTf protects and repairs the neonatal white matter after a cerebral hypoxic-ischemic event. Guardia Clausi M, et al. Glia, 2012 Oct. PMID 22736466
  4. Urinary protein markers predict the severity of renal histological lesions in children with mesangial proliferative glomerulonephritis. Li Y, et al. BMC Nephrol, 2012 May 20. PMID 22607047, Free PMC Article
  5. Deferoxamine attenuates iron-induced long-term neurotoxicity in rats with traumatic brain injury. Zhang L, et al. Neurol Sci, 2013 May. PMID 22538758

See all (102) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Neuroprotective Effects of Transferrin in Experimental Glaucoma Models.
    Title: Neuroprotective Effects of Transferrin in Experimental Glaucoma Models.
  2. Tf can be incorporated by all glial cells-i.e., microglia, astrocytes, and oligodendroglial precursor cell-and that, acting on microglial cells in vitro, Tf increases microglial proliferation rates and phagocytic capacity.
    Title: Transferrin Enhances Microglial Phagocytic Capacity.
  3. our data establish that blood TSAT exerts a critical role in experimental stroke-induced brain damage. In addition, our findings suggest that the protective effect of iron-free transferrin (apotransferrin, ATf) at the neuronal level resides in preventing NMDA-induced HTf uptake and ROS production, which in turn reduces neuronal damage
    Title: Iron-loaded transferrin (Tf) is detrimental whereas iron-free Tf confers protection against brain ischemia by modifying blood Tf saturation and subsequent neuronal damage.
  4. In brain interstitial fluid, transferrin-bound iron and non-transferrin-bound iron (NTBI) exist as potential iron sources
    Title: Molecular mechanisms of non-transferrin-bound and transferring-bound iron uptake in primary hippocampal neurons.
  5. Transferrin and thyroid hormone converge to regulate oligodendrocyte maturation and myelinogenesis.
    Title: Transferrin and thyroid hormone converge in the control of myelinogenesis.
  6. This evidence supports a key role of Tf on the generation of oligodendrocytes (OLs) from Neural stem and progenitor cells (NSC/NPCs)and highlights its potential in demyelinating disorder treatment.
    Title: ApoTransferrin: dual role on adult subventricular zone-derived neurospheres.
  7. The ceruloplasmin/transferrin ratio tended to be higher in (jugular vein) plasma of nerve-injured rats as compared to controls.
    Title: The oxidative response in the chronic constriction injury model of neuropathic pain.
  8. we have discovered a novel mitochondrial iron transport system that goes awry in Parkinson's disease, and which may provide a new target for therapeutic intervention.
    Title: A novel transferrin/TfR2-mediated mitochondrial iron transport system is disrupted in Parkinson's disease.
  9. synthesis and secretion of transferrin in rat parotid acinar cells
    Title: Transferrin secretory pathways in rat parotid acinar cells.
  10. Apotransferrin added to oligodendroglial cell cultures can correct the effects of iron deficiency.
    Title: Effect of transferrin on hypomyelination induced by iron deficiency.
Submit: New GeneRIF Correction See all GeneRIFs (19)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Potential readthrough

Included gene: Srprb

Homology

Clone Names

  • MGC93500

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables ferric iron binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ferric iron binding IEA
Inferred from Electronic Annotation
more info
  
enables ferrous iron binding ISO
Inferred from Sequence Orthology
more info
  
enables iron chaperone activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferrin receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in acute-phase response IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in antibacterial humoral response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell surface receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to cAMP IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to follicle-stimulating hormone stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to iron ion ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular iron ion homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular iron ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular iron ion homeostasis TAS
Traceable Author Statement
more info
 PubMed 
involved_in iron ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in iron ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in iron ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within iron ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in iron ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in iron ion transport TAS
Traceable Author Statement
more info
 PubMed 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in multicellular organismal-level iron ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of myelination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of oligodendrocyte progenitor proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to bacterium ISO
Inferred from Sequence Orthology
more info
  
involved_in response to hypoxia IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to lead ion IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
part_of HFE-transferrin receptor complex ISO
Inferred from Sequence Orthology
more info
  
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in basal part of cell ISO
Inferred from Sequence Orthology
more info
  
located_in basal plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in basement membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in cell tip IDA
Inferred from Direct Assay
more info
 PubMed 
located_in clathrin-coated pit ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dense body ISO
Inferred from Sequence Orthology
more info
  
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
located_in endocytic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in recycling endosome ISO
Inferred from Sequence Orthology
more info
  
located_in vesicle ISO
Inferred from Sequence Orthology
more info
  
part_of vesicle coat ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
serotransferrin
Names
beta-1 metal-binding globulin
liver regeneration-related protein LRRG03
siderophilin

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013110.1 → NP_001013128.1  serotransferrin precursor

    See identical proteins and their annotated locations for NP_001013128.1

    Status: PROVISIONAL

    Source sequence(s)
    BC087021
    UniProtKB/Swiss-Prot
    P12346, Q63602, Q64628, Q64630, Q7TNX0
    UniProtKB/TrEMBL
    A6I2I8, A6I2I9
    Related
    ENSRNOP00000045637.2, ENSRNOT00000045628.7
    Conserved Domains (4) summary
    smart00094
    Location:360 → 683
    TR_FER; Transferrin
    cd13617
    Location:357 → 682
    PBP2_transferrin_C; The C-lobe of transferrin, a member of the type 2 periplasmic binding protein fold superfamily
    cd13618
    Location:24 → 346
    PBP2_transferrin_N; The N-lobe of transferrin, a member of the type 2 periplasmic binding protein fold superfamily
    pfam00405
    Location:25 → 347
    Transferrin; Transferrin

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    112668667..112695376 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P12346.3 GenPept UniProtKB/Swiss-Prot:P12346

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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