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Gclm Glutamate-cysteine ligase modifier subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 248194, updated on 8-Oct-2018

Summary

Official Symbol
Gclmprovided by FlyBase
Official Full Name
Glutamate-cysteine ligase modifier subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0046114
Locus tag
Dmel_CG4919
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster (old-lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
4919; box; CG4919; Dmel\CG4919; DmGCLM; DmGCSl; gclm; GCLm; GCLM; Gcsl; GCSl

Genomic context

See Gclm in Genome Data Viewer
Location:
94C1-94C1; 3-76 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.13 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22685006..22686510, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18510728..18512232, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene locomotion defects Neighboring gene ncRNA Neighboring gene wide awake Neighboring gene uncharacterized protein Neighboring gene wolfram syndrome 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the Gclm gene: The Gclm gene is conserved in human, chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, mosquito, C.elegans, and frog.

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enzyme regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enzyme regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
glutamate-cysteine ligase catalytic subunit binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
behavioral response to ethanol IMP
Inferred from Mutant Phenotype
more info
PubMed 
detoxification of arsenic-containing substance IMP
Inferred from Mutant Phenotype
more info
PubMed 
glutathione biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glutathione biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
glutathione biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
long-term memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of glutamate-cysteine ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of glutamate-cysteine ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
glutamate-cysteine ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glutamate-cysteine ligase complex IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
Glutamate-cysteine ligase modifier subunit
Names
CG4919-PA
CG4919-PB
Gclm-PA
Gclm-PB
gamma-Glutamylcysteine synthetase regulatory subunit
NP_001262845.1
NP_732780.1

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    22685006..22686510 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275916.1NP_001262845.1  Glutamate-cysteine ligase modifier subunit, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262845.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VCW6
    Related
    FBpp0306672, FBtr0334605
    Conserved Domains (1) summary
    cl00470
    Location:79238
    Aldo_ket_red; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial ...
  2. NM_170034.3NP_732780.1  Glutamate-cysteine ligase modifier subunit, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732780.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VCW6
    Related
    FBpp0083729, FBtr0084336
    Conserved Domains (1) summary
    cl00470
    Location:79238
    Aldo_ket_red; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial ...
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