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Tbxa2r thromboxane A2 receptor [ Rattus norvegicus (Norway rat) ]

Gene ID: 24816, updated on 30-Sep-2021

Summary

Official Symbol
Tbxa2rprovided by RGD
Official Full Name
thromboxane A2 receptorprovided by RGD
Primary source
RGD:3825
See related
EnsemblRapid:ENSRNOG00000020585
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
binds thromboxane and induces an increase in cytosolic Ca2+ levels; may play a role renal electrolyte metabolism; may mediate vascular smooth muscle cell contraction and proliferation [RGD, Feb 2006]
Expression
Biased expression in Thymus (RPKM 104.9), Lung (RPKM 32.5) and 7 other tissues See more
Orthologs
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Genomic context

See Tbxa2r in Genome Data Viewer
Location:
7q11
Exon count:
4
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (8383347..8390753, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (11253153..11259233, complement)

Chromosome 7 - NC_051342.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102552827 Neighboring gene high mobility group 20 B Neighboring gene GIPC PDZ domain containing family, member 3 Neighboring gene cactin, spliceosome C complex subunit Neighboring gene phosphatidylinositol-4-phosphate 5-kinase type 1 gamma

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables thromboxane A2 receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables thromboxane receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables thromboxane receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of blood coagulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of blood pressure IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vasoconstriction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of vasoconstriction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
 
involved_in response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
involved_in response to nutrient IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to testosterone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within second-messenger-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in thromboxane A2 signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in water homeostasis TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in acrosomal vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
thromboxane A2 receptor
Names
TXA2-R
TXR2
Thromboxane receptor
prostanoid TP receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017054.2NP_058750.2  thromboxane A2 receptor

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000177
    Related
    ENSRNOP00000027932.2, ENSRNOT00000027932.5
    Conserved Domains (2) summary
    cd14964
    Location:2652
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:25317
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051342.1 Reference mRatBN7.2 Primary Assembly

    Range
    8383347..8390753 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039078434.1XP_038934362.1  thromboxane A2 receptor isoform X1

    Conserved Domains (2) summary
    cd14964
    Location:2652
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:25317
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  2. XM_006240846.3XP_006240908.1  thromboxane A2 receptor isoform X1

    See identical proteins and their annotated locations for XP_006240908.1

    UniProtKB/Swiss-Prot
    P34978
    Conserved Domains (2) summary
    cd14964
    Location:2652
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:25317
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  3. XM_039078435.1XP_038934363.1  thromboxane A2 receptor isoform X1

    Conserved Domains (2) summary
    cd14964
    Location:2652
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:25317
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  4. XM_039078433.1XP_038934361.1  thromboxane A2 receptor isoform X1

    Conserved Domains (2) summary
    cd14964
    Location:2652
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:25317
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
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