Tacr3 tachykinin receptor 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tacr3provided by RGD
Official Full Name: tachykinin receptor 3provided by RGD
Primary source: RGD:3810
See related: Ensembl:ENSRNOG00000009372 AllianceGenome:RGD:3810
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nkr; Nmkr; Tac3r
Summary: Enables tachykinin receptor activity. Involved in several processes, including positive regulation of uterine smooth muscle contraction; regulation of dopamine metabolic process; and response to estradiol. Located in dendrite membrane and neuronal cell body membrane. Used to study hypertension. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 11 with or without anosmia. Orthologous to human TACR3 (tachykinin receptor 3). [provided by Alliance of Genome Resources, Apr 2025]
Expression: Biased expression in Brain (RPKM 30.9), Kidney (RPKM 7.7) and 4 other tissues See more
Orthologs: all
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Genomic context

Location:: 2q43

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (225940497..226037756)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (223266536..223363791)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (240021152..240118971)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The different impacts of diverse long-term exercise intensities on the male pituitary-gonadal axis maybe relay by the various changes in hypothalamic Nkb and Pdyn gene expressions.
Title: Various responses of male pituitary-gonadal axis to different intensities of long-term exercise: Role of expression of KNDYrelated genes.
Results give support to the involvement of NK3 receptors in the anxiogenic-like actions of SP6-11(C-terminal), where this metabolite seems to behave as an antagonist, in a way similar to SR142801.
Title: Evidence for involvement of NK₃ receptors in the anxiogenic-like effect of SP6-11(C-terminal), a metabolite of substance P, in rats evaluated in the elevated plus-maze.
Median preoptic nucleus NK3R neurons facilitate cutaneous vasodilation, an important heat-dissipation effector.
Title: Neurokinin 3 Receptor-Expressing Neurons in the Median Preoptic Nucleus Modulate Heat-Dissipation Effectors in the Female Rat.
data suggest that endogenous NeuroKinin B-Neurokinin 3 Receptor signalling plays a role in controlling the timing of puberty.
Title: Neurokinin B receptor antagonism decreases luteinising hormone pulse frequency and amplitude and delays puberty onset in the female rat.
Data indicate that the suppression of the GnRH pulse generator by acute systemic stress equires hypothalamic NKB/neurokinin B (NKB) receptor (NK3R) signaling.
Title: Neurokinin B signaling in the female rat: a novel link between stress and reproduction.
evidence that the neurokinin3 receptors (NK3-R) and their influence on acetylcholine release may represent a crucial mechanism that underlies age-related deficits in learning and memory
Title: Neurokinin3 receptor as a target to predict and improve learning and memory in the aged organism.
Activation of the NK3R appears to recruit multiple pathways, including acetylation, and possibly histone deactylases, histone methylases, or DNA methylases to affect chromatin structure and gene expression.
Title: Activation of tachykinin, neurokinin 3 receptors affects chromatin structure and gene expression by means of histone acetylation.
data provide unique evidence that KNDy neurons promote cutaneous vasodilatation and participate in the E(2) modulation of body temperature
Title: Role for kisspeptin/neurokinin B/dynorphin (KNDy) neurons in cutaneous vasodilatation and the estrogen modulation of body temperature.
Nkr3 peptide may exacerbate 6-OHDA toxicity in an in-vivo model, by modulation of N-methyl-D-aspartate receptor (Grin)1 subunit and c-Jun N-terminal kinase (JNK) pathway activities.
Title: Neurokinin receptor 3 peptide exacerbates 6-hydroxydopamine-induced dopaminergic degeneration in rats through JNK pathway.
Since NK3-R is widely distributed in the CNS, the presence of NK3-R in nuclei from multiple brain regions suggests that it may broadly influence CNS gene expression in a ligand-dependent manner.
Title: Characterization of nuclear neurokinin 3 receptor expression in rat brain.

Submit: New GeneRIF Correction See all GeneRIFs (24)

General gene information

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Markers

Tacr3 (e-PCR), detects polymorphism
- UniSTS:507269

Tacr3 (e-PCR), detects polymorphism
- UniSTS:144539

D2Rat64 (e-PCR)
- UniSTS:118714

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables neuromedin K receptor activity	IEA Inferred from Electronic Annotation more info
enables neuromedin K receptor activity	ISO Inferred from Sequence Orthology more info
enables tachykinin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables tachykinin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables tachykinin receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in conditioned place preference	IDA Inferred from Direct Assay more info	PubMed
involved_in drinking behavior	IDA Inferred from Direct Assay more info	PubMed
involved_in drinking behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipase C-activating tachykinin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in phospholipase C-activating tachykinin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in phospholipase C-activating tachykinin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood pressure	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of flagellated sperm motility	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of flagellated sperm motility	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of flagellated sperm motility	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of heart rate	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of luteinizing hormone secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of uterine smooth muscle contraction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of uterine smooth muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in regulation of dopamine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of feeding behavior	IDA Inferred from Direct Assay more info	PubMed
involved_in response to cocaine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to estradiol	IDA Inferred from Direct Assay more info	PubMed
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in vagina development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon terminus	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite membrane	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine head	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in sperm midpiece	IBA Inferred from Biological aspect of Ancestor more info
located_in sperm midpiece	IEA Inferred from Electronic Annotation more info
located_in sperm midpiece	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: neuromedin-K receptor

Names: NK-3 receptor; NK-3R; Neuromedin K receptor (Neurokinin B/Tachikin 3); neurokinin B receptor; tachikin receptor 3

NP_058749.1

EC 2.7.11.14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017053.1 → NP_058749.1 neuromedin-K receptor

See identical proteins and their annotated locations for NP_058749.1

Status: PROVISIONAL

Source sequence(s)

J05189

UniProtKB/Swiss-Prot

P16177

UniProtKB/TrEMBL

A6HVV9

Related

ENSRNOP00000012473.2, ENSRNOT00000012473.4

Conserved Domains (2) summary

pfam00001
Location:89 → 343

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:81 → 204

7tm_4; Olfactory receptor