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Tacr3 tachykinin receptor 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24808, updated on 22-Sep-2022

Summary

Official Symbol
Tacr3provided by RGD
Official Full Name
tachykinin receptor 3provided by RGD
Primary source
RGD:3810
See related
Ensembl:ENSRNOG00000009372 AllianceGenome:RGD:3810
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Nkr; Nmkr; Tac3r
Summary
Enables tachykinin receptor activity. Involved in several processes, including hyperosmotic salinity response; positive regulation of uterine smooth muscle contraction; and response to alkaloid. Located in several cellular components, including dendrite membrane; neuronal cell body membrane; and nucleus. Used to study hypertension. Biomarker of visual epilepsy. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 11 with or without anosmia. Orthologous to human TACR3 (tachykinin receptor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 30.9), Kidney (RPKM 7.7) and 4 other tissues See more
Orthologs
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Genomic context

See Tacr3 in Genome Data Viewer
Location:
2q43
Exon count:
5
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (223266536..223363791)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (240021152..240118971)

Chromosome 2 - NC_051337.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100946 Neighboring gene CXXC finger protein 4 Neighboring gene DTW domain containing 2, pseudogene 1 Neighboring gene 40S ribosomal protein S26-like Neighboring gene myosin light chain 12A, pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables tachykinin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables tachykinin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in sperm midpiece IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in sperm midpiece ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
neuromedin-K receptor
Names
NK-3 receptor
NK-3R
Neuromedin K receptor (Neurokinin B/Tachikin 3)
neurokinin B receptor
tachikin receptor 3
NP_058749.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017053.1NP_058749.1  neuromedin-K receptor

    See identical proteins and their annotated locations for NP_058749.1

    Status: PROVISIONAL

    Source sequence(s)
    J05189
    UniProtKB/Swiss-Prot
    P16177
    Related
    ENSRNOP00000012473.2, ENSRNOT00000012473.3
    Conserved Domains (2) summary
    pfam00001
    Location:89343
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:81204
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051337.1 Reference mRatBN7.2 Primary Assembly

    Range
    223266536..223363791
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)