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Sod2 superoxide dismutase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24787, updated on 5-Jan-2023

Summary

Official Symbol
Sod2provided by RGD
Official Full Name
superoxide dismutase 2provided by RGD
Primary source
RGD:3732
See related
Ensembl:ENSRNOG00000019048 AllianceGenome:RGD:3732
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
MnSOD
Summary
Enables several functions, including identical protein binding activity; manganese ion binding activity; and superoxide dismutase activity. Involved in several processes, including hydrogen peroxide biosynthetic process; negative regulation of membrane hyperpolarization; and positive regulation of hydrogen peroxide biosynthetic process. Located in mitochondrial nucleoid. Used to study esophagus adenocarcinoma; hypertension; intestinal disease; and myocardial infarction. Biomarker of several diseases, including adult respiratory distress syndrome; artery disease (multiple); bladder neck obstruction; congenital diaphragmatic hernia; and hyperhomocysteinemia. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); lipid storage disease (multiple); liver disease (multiple); and optic nerve disease (multiple). Orthologous to human SOD2 (superoxide dismutase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 2100.6), Heart (RPKM 1328.2) and 8 other tissues See more
Orthologs
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Genomic context

See Sod2 in Genome Data Viewer
Location:
1q11
Exon count:
5
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (47638318..47645163, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (47914757..47921587, complement)

Chromosome 1 - NC_051336.1Genomic Context describing neighboring genes Neighboring gene fibronectin type III domain containing 1 Neighboring gene uncharacterized LOC103690969 Neighboring gene ATP synthase F1 subunit gamma, pseudogene 1 Neighboring gene uncharacterized LOC102553528 Neighboring gene WT1 associated protein Neighboring gene acetyl-CoA acetyltransferase 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

  • Homologs of the Sod2 gene: The Sod2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
  • Orthologs from Annotation Pipeline: 487 organisms have orthologs with human gene Sod2
  • Orthologs

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables manganese ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables manganese ion binding ISO
Inferred from Sequence Orthology
more info
 
enables manganese ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
 
enables oxygen binding IDA
Inferred from Direct Assay
more info
PubMed 
enables superoxide dismutase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables superoxide dismutase activity ISO
Inferred from Sequence Orthology
more info
 
enables superoxide dismutase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure ISO
Inferred from Sequence Orthology
more info
 
involved_in aging IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within apoptotic mitochondrial changes ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to oxidative stress ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within detection of oxygen ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within erythrophore differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within glutathione metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within heart development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within hemopoiesis ISO
Inferred from Sequence Orthology
more info
 
involved_in hydrogen peroxide biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in hydrogen peroxide metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular oxygen homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within iron ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within liver development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within locomotory behavior ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mitochondrion organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of membrane hyperpolarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of vascular associated smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuron development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of hydrogen peroxide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular associated smooth muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within post-embryonic development ISO
Inferred from Sequence Orthology
more info
 
involved_in protein homotetramerization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of catalytic activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of mitochondrial membrane potential ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within release of cytochrome c from mitochondria ISO
Inferred from Sequence Orthology
more info
 
involved_in removal of superoxide radicals IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within removal of superoxide radicals ISO
Inferred from Sequence Orthology
more info
 
involved_in removal of superoxide radicals ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within respiratory electron transport chain ISO
Inferred from Sequence Orthology
more info
 
involved_in response to L-ascorbic acid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to activity IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within response to activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to axon injury ISO
Inferred from Sequence Orthology
more info
 
involved_in response to cadmium ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to cold IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to electrical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within response to gamma radiation ISO
Inferred from Sequence Orthology
more info
 
involved_in response to hydrogen peroxide IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to hyperoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to immobilization stress IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to isolation stress IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to magnetism IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to manganese ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to nutrient levels IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to oxidative stress IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
involved_in response to radiation IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
 
involved_in response to selenium ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to silicon dioxide IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within response to superoxide ISO
Inferred from Sequence Orthology
more info
 
involved_in response to superoxide ISO
Inferred from Sequence Orthology
more info
 
involved_in response to xenobiotic stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to zinc ion IEP
Inferred from Expression Pattern
more info
PubMed 
NOT acts_upstream_of_or_within sensory perception of sound ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within superoxide anion generation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within superoxide metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in superoxide metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in superoxide metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within vasodilation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial nucleoid IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
superoxide dismutase [Mn], mitochondrial
Names
Superoxide dimutase 2, mitochondrial
manganese superoxide dismutase
mitochondrial superoxide dismutase 2
superoxide dismutase 2, mitochondrial
NP_058747.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017051.2NP_058747.1  superoxide dismutase [Mn], mitochondrial precursor

    See identical proteins and their annotated locations for NP_058747.1

    Status: PROVISIONAL

    Source sequence(s)
    BC070913
    UniProtKB/Swiss-Prot
    P07895
    Related
    ENSRNOP00000025794.3, ENSRNOT00000025794.5
    Conserved Domains (1) summary
    COG0605
    Location:25217
    SodA; Superoxide dismutase [Inorganic ion transport and metabolism]

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051336.1 Reference mRatBN7.2 Primary Assembly

    Range
    47638318..47645163 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)