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Slc9a3 solute carrier family 9 member A3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24784, updated on 18-Apr-2019

Summary

Official Symbol
Slc9a3provided by RGD
Official Full Name
solute carrier family 9 member A3provided by RGD
Primary source
RGD:3720
See related
Ensembl:ENSRNOG00000015159
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Nhe3
Summary
displays Na+/H+ exchanger transport activity; mediates sodium ion transport across the renal proximal tubule [RGD, Feb 2006]
Expression
Biased expression in Kidney (RPKM 198.2) and Brain (RPKM 11.8) See more
Orthologs

Genomic context

See Slc9a3 in Genome Data Viewer
Location:
1p11
Exon count:
16
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (31731652..31777144, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (33159607..33201753, complement)

Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene aryl-hydrocarbon receptor repressor Neighboring gene uncharacterized LOC102548594 Neighboring gene uncharacterized LOC108349507 Neighboring gene exocyst complex component 3 Neighboring gene centrosomal protein 72 Neighboring gene tubulin polymerization promoting protein

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
PDZ domain binding IEA
Inferred from Electronic Annotation
more info
 
PDZ domain binding ISO
Inferred from Sequence Orthology
more info
PubMed 
PDZ domain binding ISS
Inferred from Sequence or Structural Similarity
more info
 
potassium:proton antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sodium:proton antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sodium:proton antiporter activity IDA
Inferred from Direct Assay
more info
PubMed 
sodium:proton antiporter activity IEA
Inferred from Electronic Annotation
more info
 
sodium:proton antiporter activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
circadian rhythm IEP
Inferred from Expression Pattern
more info
PubMed 
potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
receptor-mediated endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of intracellular pH IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of pH IDA
Inferred from Direct Assay
more info
PubMed 
regulation of pH IEA
Inferred from Electronic Annotation
more info
 
regulation of pH ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of sodium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to glucocorticoid IEP
Inferred from Expression Pattern
more info
PubMed 
sodium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sodium ion import across plasma membrane IEA
Inferred from Electronic Annotation
more info
 
sodium ion import across plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
sodium ion import across plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
sodium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
sodium ion transport ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
apical plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
brush border IDA
Inferred from Direct Assay
more info
PubMed 
brush border membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
brush border membrane IDA
Inferred from Direct Assay
more info
PubMed 
brush border membrane IEA
Inferred from Electronic Annotation
more info
 
brush border membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
extracellular exosome IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
vesicle ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
sodium/hydrogen exchanger 3
Names
NHE-3
Na(+)/H(+) exchanger 3
Solute carrier family 9 (sodium/hydrogen exchanger 3), antiporter 3, Na+/H+ (amiloride insensitive)
plasma membrane ion transport protein
solute carrier family 9 (sodium/hydrogen exchanger), member 3
solute carrier family 9 member 3
solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012654.1NP_036786.1  sodium/hydrogen exchanger 3 precursor

    See identical proteins and their annotated locations for NP_036786.1

    Status: PROVISIONAL

    Source sequence(s)
    M85300
    UniProtKB/Swiss-Prot
    P26433
    Related
    ENSRNOP00000020711.2, ENSRNOT00000020711.3
    Conserved Domains (3) summary
    TIGR00840
    Location:45644
    b_cpa1; sodium/hydrogen exchanger 3
    pfam00999
    Location:102459
    Na_H_Exchanger; Sodium/hydrogen exchanger family
    pfam16644
    Location:602674
    NEXCaM_BD; Regulatory region of Na+/H+ exchanger NHE binds to calmodulin

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

    Range
    31731652..31777144 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008758677.2XP_008756899.1  sodium/hydrogen exchanger 3 isoform X1

    See identical proteins and their annotated locations for XP_008756899.1

    UniProtKB/TrEMBL
    G3V7Y7
    Conserved Domains (3) summary
    TIGR00840
    Location:45644
    b_cpa1; sodium/hydrogen exchanger 3
    pfam00999
    Location:102459
    Na_H_Exchanger; Sodium/hydrogen exchanger family
    pfam16644
    Location:602674
    NEXCaM_BD; Regulatory region of Na+/H+ exchanger NHE binds to calmodulin

Alternate Rn_Celera

Genomic

  1. AC_000069.1 Alternate Rn_Celera

    Range
    27776582..27819219 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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