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Slc9a1 solute carrier family 9 member A1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24782, updated on 11-Apr-2024

Summary

Official Symbol
Slc9a1provided by RGD
Official Full Name
solute carrier family 9 member A1provided by RGD
Primary source
RGD:3718
See related
Ensembl:ENSRNOG00000007982 AllianceGenome:RGD:3718
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Nhe1
Summary
Enables sodium:proton antiporter activity. Involved in several processes, including cellular response to electrical stimulus; positive regulation of mitochondrial membrane permeability; and regulation of apoptotic process. Located in several cellular components, including T-tubule; basolateral plasma membrane; and intercalated disc. Used to study cataract; middle cerebral artery infarction; and proteinuria. Biomarker of hyperthyroidism; hypothyroidism; renovascular hypertension; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 19 and congestive heart failure. Orthologous to human SLC9A1 (solute carrier family 9 member A1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 66.7), Adrenal (RPKM 51.8) and 9 other tissues See more
Orthologs
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Genomic context

Location:
5q36
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (150859412..150913525)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (145576341..145629630)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (151573122..151626360)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134487005 Neighboring gene transmembrane protein 222 Neighboring gene WD and tetratricopeptide repeats 1 Neighboring gene uncharacterized LOC134487006 Neighboring gene uncharacterized LOC134487001 Neighboring gene uncharacterized LOC134479037

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium-dependent protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables phospholipid binding ISO
Inferred from Sequence Orthology
more info
 
enables potassium:proton antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase 2B binding ISO
Inferred from Sequence Orthology
more info
 
enables sodium:proton antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables sodium:proton antiporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables sodium:proton antiporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables sodium:proton antiporter activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cardiac muscle cell contraction IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within cardiac muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to acidic pH ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to acidic pH ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to antibiotic IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to cold IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to electrical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to epinephrine stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to insulin stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in intracellular sodium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of calcineurin-NFAT signaling cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cardiac muscle hypertrophy ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of intracellular signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of mitochondrial membrane permeability IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of the force of heart contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in proton transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cardiac muscle contraction by calcium ion signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of intracellular pH IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of intracellular pH IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of intracellular pH ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of intracellular pH ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within regulation of pH ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of pH ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of pH ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of the force of heart contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of the force of heart contraction by cardiac conduction ISO
Inferred from Sequence Orthology
more info
 
involved_in response to acidic pH IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to acidic pH ISO
Inferred from Sequence Orthology
more info
 
involved_in response to acidic pH ISO
Inferred from Sequence Orthology
more info
 
involved_in response to acidic pH ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to muscle stretch ISO
Inferred from Sequence Orthology
more info
 
involved_in response to organic cyclic compound IDA
Inferred from Direct Assay
more info
PubMed 
involved_in sodium ion export across plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in sodium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in sodium ion import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within sodium ion transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within stem cell differentiation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in T-tubule IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of cation-transporting ATPase complex ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in intercalated disc IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in sarcolemma IDA
Inferred from Direct Assay
more info
PubMed 
part_of transporter complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
sodium/hydrogen exchanger 1
Names
NHE-1
Na(+)/H(+) exchanger 1
Solute carrier family 9 (sodium/hydrogen exchanger 1), antiporter, Na+/H+, (amiloride sensitive)
solute carrier family 9 (sodium/hydrogen exchanger), member 1
solute carrier family 9 member 1
solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012652.2NP_036784.1  sodium/hydrogen exchanger 1

    See identical proteins and their annotated locations for NP_036784.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    P26431
    UniProtKB/TrEMBL
    A6ISW5
    Related
    ENSRNOP00000011049.2, ENSRNOT00000011049.5
    Conserved Domains (3) summary
    TIGR00840
    Location:99664
    b_cpa1; sodium/hydrogen exchanger 3
    pfam00999
    Location:109507
    Na_H_Exchanger; Sodium/hydrogen exchanger family
    pfam16644
    Location:606704
    NEXCaM_BD; Regulatory region of Na+/H+ exchanger NHE binds to calmodulin

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    150859412..150913525
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063287163.1XP_063143233.1  sodium/hydrogen exchanger 1 isoform X1

  2. XM_063287164.1XP_063143234.1  sodium/hydrogen exchanger 1 isoform X2

RNA

  1. XR_005504368.2 RNA Sequence