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MTOR mechanistic target of rapamycin kinase [ Homo sapiens (human) ]

Gene ID: 2475, updated on 3-May-2025
Official Symbol
MTORprovided by HGNC
Official Full Name
mechanistic target of rapamycin kinaseprovided by HGNC
Primary source
HGNC:HGNC:3942
See related
Ensembl:ENSG00000198793 MIM:601231; AllianceGenome:HGNC:3942
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SKS; FRAP; FRAP1; FRAP2; RAFT1; RAPT1
Summary
The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This kinase is a component of two distinct complexes, mTORC1, which controls protein synthesis, cell growth and proliferation, and mTORC2, which is a regulator of the actin cytoskeleton, and promotes cell survival and cell cycle progression. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. Inhibitors of mTOR are used in organ transplants as immunosuppressants, and are being evaluated for their therapeutic potential in SARS-CoV-2 infections. Mutations in this gene are associated with Smith-Kingsmore syndrome and somatic focal cortical dysplasia type II. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Aug 2020]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is relevant for COVID-19 treatment.
Expression
Broad expression in testis (RPKM 23.6), brain (RPKM 8.1) and 25 other tissues See more
Orthologs
NEW
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Try the new Transcript table
See MTOR in Genome Data Viewer
Location:
1p36.22
Exon count:
60
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (11106535..11262551, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (10648106..10804142, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (11166592..11322608, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 259 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 260 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 162 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 163 Neighboring gene exosome component 10 Neighboring gene spermidine synthase Neighboring gene ReSE screen-validated silencer GRCh37_chr1:11152350-11152530 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:11159092-11159654 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:11159655-11160215 Neighboring gene EXOSC10 antisense RNA 1 Neighboring gene MTOR antisense RNA 1 Neighboring gene RNA, U6 small nuclear 537, pseudogene Neighboring gene small nucleolar RNA U13 Neighboring gene NANOG hESC enhancer GRCh37_chr1:11237905-11238443 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:11249765-11250265 Neighboring gene MPRA-validated peak73 silencer Neighboring gene angiopoietin like 7 Neighboring gene RNA, U6 small nuclear 291, pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:11301605-11302164 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:11308472-11309038 Neighboring gene ribosomal protein L39 pseudogene 6 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 261 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 165 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 262 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 263 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 166 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 167 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:11349216-11349398 Neighboring gene ubiquitin conjugating enzyme E2 V2 pseudogene 3 Neighboring gene UbiA prenyltransferase domain containing 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:11365397-11366222 Neighboring gene uncharacterized LOC105376737

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Associated conditions

Description Tests
Isolated focal cortical dysplasia type II
MedGen: C1846385 OMIM: 607341 GeneReviews: Not available
Compare labs
Macrocephaly-intellectual disability-neurodevelopmental disorder-small thorax syndrome
MedGen: C4225259 OMIM: 616638 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Association of variants in FRAP1 and PDGFRA with corneal curvature in Asian populations from Singapore.
EBI GWAS Catalog
CMPK1 and RBP3 are associated with corneal curvature in Asian populations.
EBI GWAS Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Syncytia arising from the fusion of cells expressing HIV-1 gp120 with cells expressing the CD4/CXCR4 complex causes phosphorylation of p53, which is mediated by the upregulation of mammalian target of FKBP12-rapamycin-associated protein (FRAP) PubMed
Nef nef HIV-1 Nef synergizes with KSHV oncoprotein K1 to activate PI3K/AKT/mTOR signaling pathway, and induces cell proliferation and microtubule formation in endothelial cells PubMed
Tat tat HIV-1 Tat induces phosphorylation of mTOR in Tat-expressing cells and HIV-1-infected cells PubMed
capsid gag Treatment with Torin 1, mTOR kinase inhibitor, significantly downregulates HIV-1 p24 levels in HIV-1-infected primary CD4+ T cells, Jurkat cells, and MOLT-X4 cells, suggesting mTOR kinase regulates HIV-1 production PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • FLJ44809

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase III type 1 promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase III type 2 promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase III type 3 promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables TFIIIC-class transcription factor complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables inositol hexakisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphoprotein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity EXP
Inferred from Experiment
more info
PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
enables protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
enables ribosome binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ribosome binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane transporter binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in 'de novo' pyrimidine nucleobase biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA damage response NAS
Non-traceable Author Statement
more info
PubMed 
involved_in T cell costimulation TAS
Traceable Author Statement
more info
 
involved_in T-helper 1 cell lineage commitment IEA
Inferred from Electronic Annotation
more info
 
involved_in TOR signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in TOR signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in TOR signaling NAS
Non-traceable Author Statement
more info
PubMed 
involved_in TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in TORC1 signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in TORC2 signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in TORC2 signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in TORC2 signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in anoikis NAS
Non-traceable Author Statement
more info
PubMed 
involved_in behavioral response to pain IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of calcineurin-NFAT signaling cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in cardiac cell development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cardiac muscle cell development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cardiac muscle contraction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cardiac muscle tissue development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to L-leucine IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to amino acid starvation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to amino acid stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to hypoxia ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to hypoxia NAS
Non-traceable Author Statement
more info
PubMed 
involved_in cellular response to insulin stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to insulin stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to leucine starvation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to methionine IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to nutrient IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to nutrient levels IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to nutrient levels IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to nutrient levels ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to nutrient levels NAS
Non-traceable Author Statement
more info
PubMed 
involved_in cellular response to osmotic stress NAS
Non-traceable Author Statement
more info
PubMed 
involved_in cellular response to starvation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cytoskeleton organization NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within energy reserve metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within germ cell development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within heart morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within heart valve morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of macroautophagy IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of apoptotic process NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of autophagy IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of autophagy IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of autophagy ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of autophagy NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within negative regulation of calcineurin-NFAT signaling cascade IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of cell size IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of insulin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of lysosome organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of macroautophagy IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of macroautophagy IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of macroautophagy IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of protein localization to nucleus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neuronal action potential IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of oligodendrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of actin filament polymerization IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell growth NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of cytoplasmic translational initiation TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of glycolytic process NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of keratinocyte migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of lamellipodium assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of lipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of lipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of lipid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of lipid biosynthetic process NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within positive regulation of myotube differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of oligodendrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of pentose-phosphate shunt NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction TAS
Traceable Author Statement
more info
 
acts_upstream_of_or_within positive regulation of stress fiber assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase III IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription of nucleolar large rRNA by RNA polymerase I IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of translation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of translational initiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of positive regulation of ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of wound healing, spreading of epidermal cells IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within post-embryonic development IEA
Inferred from Electronic Annotation
more info
 
involved_in protein destabilization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein stabilization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of autophagosome assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of autophagy IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell growth IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cell size IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cellular component organization IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cellular response to heat TAS
Traceable Author Statement
more info
 
involved_in regulation of cellular response to stress IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of circadian rhythm IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of locomotor rhythm IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of locomotor rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of lysosome organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of macroautophagy TAS
Traceable Author Statement
more info
 
acts_upstream_of_or_within regulation of membrane permeability IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of myelination IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of osteoclast differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of osteoclast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of protein metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of signal transduction by p53 class mediator TAS
Traceable Author Statement
more info
 
involved_in response to amino acid IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to amino acid IEA
Inferred from Electronic Annotation
more info
 
involved_in response to heat IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within response to insulin IEA
Inferred from Electronic Annotation
more info
 
involved_in response to nutrient levels IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to virus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within ruffle organization IEA
Inferred from Electronic Annotation
more info
 
involved_in vascular endothelial cell response to laminar fluid shear stress TAS
Traceable Author Statement
more info
 
acts_upstream_of_or_within voluntary musculoskeletal movement IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with PML body IEA
Inferred from Electronic Annotation
more info
 
located_in PML body IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with PML body ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of TORC1 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of TORC1 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of TORC1 complex IEA
Inferred from Electronic Annotation
more info
 
part_of TORC1 complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of TORC1 complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of TORC2 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of TORC2 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of TORC2 complex IEA
Inferred from Electronic Annotation
more info
 
part_of TORC2 complex IPI
Inferred from Physical Interaction
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 
located_in endomembrane system IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
located_in lysosomal membrane HDA PubMed 
is_active_in lysosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
 
located_in lysosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
located_in lysosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in membrane HDA PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in phagocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in phagocytic vesicle IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
part_of serine/threonine protein kinase complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
serine/threonine-protein kinase mTOR
Names
FK506 binding protein 12-rapamycin associated protein 2
FK506-binding protein 12-rapamycin complex-associated protein 1
FKBP-rapamycin associated protein
FKBP12-rapamycin complex-associated protein 1
mammalian target of rapamycin
mechanistic target of rapamycin (serine/threonine kinase)
rapamycin and FKBP12 target 1
rapamycin associated protein FRAP2
rapamycin target protein 1
tyrosine-protein kinase mTOR
NP_001373429.1
NP_001373430.1
NP_004949.1
XP_011539468.1
XP_016856389.1
XP_047272677.1
XP_047272680.1
XP_054191719.1
XP_054191720.1
XP_054191721.1
XP_054191722.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033239.1 RefSeqGene

    Range
    5001..161021
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_734

mRNA and Protein(s)

  1. NM_001386500.1NP_001373429.1  serine/threonine-protein kinase mTOR isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AL049653, AL109811, AL391561
    Consensus CDS
    CCDS127.1
    UniProtKB/Swiss-Prot
    P42345, Q4LE76, Q5TER1, Q6LE87, Q96QG3, Q9Y4I3
    UniProtKB/TrEMBL
    A0A8V8TRG9
    Conserved Domains (2) summary
    COG5032
    Location:3632549
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    sd00044
    Location:655681
    HEAT; HEAT repeat [structural motif]
  2. NM_001386501.1NP_001373430.1  serine/threonine-protein kinase mTOR isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL049653, AL109811, AL391561
    UniProtKB/TrEMBL
    A0A8V8TRG9
    Conserved Domains (2) summary
    COG5032
    Location:662133
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    sd00044
    Location:239265
    HEAT; HEAT repeat [structural motif]
  3. NM_004958.4NP_004949.1  serine/threonine-protein kinase mTOR isoform 1

    See identical proteins and their annotated locations for NP_004949.1

    Status: REVIEWED

    Description
    Transcript Variant: Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AA725390, AB209995, BC117166, BP250183, DC403129, L34075, U88966
    Consensus CDS
    CCDS127.1
    UniProtKB/Swiss-Prot
    P42345, Q4LE76, Q5TER1, Q6LE87, Q96QG3, Q9Y4I3
    UniProtKB/TrEMBL
    A0A8V8TRG9
    Related
    ENSP00000354558.4, ENST00000361445.9
    Conserved Domains (2) summary
    COG5032
    Location:3632549
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    sd00044
    Location:655681
    HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    11106535..11262551 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017000900.1XP_016856389.1  serine/threonine-protein kinase mTOR isoform X2

    UniProtKB/TrEMBL
    A0A8V8TRG9
  2. XM_047416724.1XP_047272680.1  serine/threonine-protein kinase mTOR isoform X3

  3. XM_047416721.1XP_047272677.1  serine/threonine-protein kinase mTOR isoform X1

    UniProtKB/TrEMBL
    A0A8V8TQN3
  4. XM_011541166.3XP_011539468.1  serine/threonine-protein kinase mTOR isoform X4

    UniProtKB/TrEMBL
    A0A8V8TQ52, A0A8V8TQM6
    Related
    ENSP00000515198.1, ENST00000703141.1
    Conserved Domains (3) summary
    COG5032
    Location:3631587
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    pfam11865
    Location:8541024
    DUF3385; Domain of unknown function (DUF3385)
    sd00044
    Location:655681
    HEAT; HEAT repeat [structural motif]

RNA

  1. XR_007058581.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    10648106..10804142 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054335745.1XP_054191720.1  serine/threonine-protein kinase mTOR isoform X2

    UniProtKB/TrEMBL
    A0A8V8TRG9
  2. XM_054335746.1XP_054191721.1  serine/threonine-protein kinase mTOR isoform X3

  3. XM_054335744.1XP_054191719.1  serine/threonine-protein kinase mTOR isoform X1

    UniProtKB/TrEMBL
    A0A8V8TQN3
  4. XM_054335747.1XP_054191722.1  serine/threonine-protein kinase mTOR isoform X4

    UniProtKB/TrEMBL
    A0A8V8TQ52, A0A8V8TQM6

RNA

  1. XR_008485983.1 RNA Sequence