MTOR mechanistic target of rapamycin kinase [ Homo sapiens (human) ]

Gene ID: 2475, updated on 3-May-2025

Summary

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Official Symbol: MTORprovided by HGNC
Official Full Name: mechanistic target of rapamycin kinaseprovided by HGNC
Primary source: HGNC:HGNC:3942
See related: Ensembl:ENSG00000198793 MIM:601231; AllianceGenome:HGNC:3942
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SKS; FRAP; FRAP1; FRAP2; RAFT1; RAPT1
Summary: The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This kinase is a component of two distinct complexes, mTORC1, which controls protein synthesis, cell growth and proliferation, and mTORC2, which is a regulator of the actin cytoskeleton, and promotes cell survival and cell cycle progression. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. Inhibitors of mTOR are used in organ transplants as immunosuppressants, and are being evaluated for their therapeutic potential in SARS-CoV-2 infections. Mutations in this gene are associated with Smith-Kingsmore syndrome and somatic focal cortical dysplasia type II. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Aug 2020]
Annotation information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is relevant for COVID-19 treatment.
Expression: Broad expression in testis (RPKM 23.6), brain (RPKM 8.1) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

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See MTOR in Genome Data Viewer

Location:: 1p36.22

Exon count:: 60

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (11106535..11262551, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (10648106..10804142, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (11166592..11322608, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Multifocal, multiphenotypic tumours arising from an MTOR mutation acquired in early embryogenesis.
Title: Multifocal, multiphenotypic tumours arising from an MTOR mutation acquired in early embryogenesis.
Hypoxic glioma-derived exosomal miR-25-3p promotes macrophage M2 polarization by activating the PI3K-AKT-mTOR signaling pathway.
Title: Hypoxic glioma-derived exosomal miR-25-3p promotes macrophage M2 polarization by activating the PI3K-AKT-mTOR signaling pathway.
mTOR signalling controls the formation of smooth muscle cell-derived luminal myofibroblasts during vasculitis.
Title: mTOR signalling controls the formation of smooth muscle cell-derived luminal myofibroblasts during vasculitis.
Lactate-upregulated ARG2 expression induces cellular senescence in fibroblast-like synoviocytes of osteoarthritis via activating the mTOR/S6K1 signaling pathway.
Title: Lactate-upregulated ARG2 expression induces cellular senescence in fibroblast-like synoviocytes of osteoarthritis via activating the mTOR/S6K1 signaling pathway.
Brain insulin resistance in Down syndrome: Involvement of PI3K-Akt/mTOR axis in early-onset of Alzheimer's disease and its potential as a therapeutic target.
Title: Brain insulin resistance in Down syndrome: Involvement of PI3K-Akt/mTOR axis in early-onset of Alzheimer's disease and its potential as a therapeutic target.
Assembly of mTORC3 Involves Binding of ETV7 to Two Separate Sequences in the mTOR Kinase Domain.
Title: Assembly of mTORC3 Involves Binding of ETV7 to Two Separate Sequences in the mTOR Kinase Domain.
Homocysteine metabolites impair the PHF8/H4K20me1/mTOR/autophagy pathway by upregulating the expression of histone demethylase PHF8-targeting microRNAs in human vascular endothelial cells and mice.
Title: Homocysteine metabolites impair the PHF8/H4K20me1/mTOR/autophagy pathway by upregulating the expression of histone demethylase PHF8-targeting microRNAs in human vascular endothelial cells and mice.
The downregulation of SASH1 expression promotes breast cancer occurrence and invasion accompanied by the activation of PI3K-Akt-mTOR signaling pathway.
Title: The downregulation of SASH1 expression promotes breast cancer occurrence and invasion accompanied by the activation of PI3K-Akt-mTOR signaling pathway.
Protein kinase C iota promotes glycolysis via PI3K/AKT/mTOR signalling in high grade serous ovarian cancer.
Title: Protein kinase C iota promotes glycolysis via PI3K/AKT/mTOR signalling in high grade serous ovarian cancer.
MiR-199a-3p regulates HCT-8 cell autophagy and apoptosis in response to Cryptosporidium parvum infection by targeting MTOR.
Title: MiR-199a-3p regulates HCT-8 cell autophagy and apoptosis in response to Cryptosporidium parvum infection by targeting MTOR.

Submit: New GeneRIF Correction See all GeneRIFs (2211)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Isolated focal cortical dysplasia type II MedGen: C1846385 OMIM: 607341 GeneReviews: Not available	Compare labs
Macrocephaly-intellectual disability-neurodevelopmental disorder-small thorax syndrome MedGen: C4225259 OMIM: 616638 GeneReviews: Not available	Compare labs

EBI GWAS Catalog

Description
Association of variants in FRAP1 and PDGFRA with corneal curvature in Asian populations from Singapore. EBI GWAS Catalog EBI GWAS CatalogPubMed
CMPK1 and RBP3 are associated with corneal curvature in Asian populations. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Syncytia arising from the fusion of cells expressing HIV-1 gp120 with cells expressing the CD4/CXCR4 complex causes phosphorylation of p53, which is mediated by the upregulation of mammalian target of FKBP12-rapamycin-associated protein (FRAP)	PubMed
Nef	nef	HIV-1 Nef synergizes with KSHV oncoprotein K1 to activate PI3K/AKT/mTOR signaling pathway, and induces cell proliferation and microtubule formation in endothelial cells	PubMed
Tat	tat	HIV-1 Tat induces phosphorylation of mTOR in Tat-expressing cells and HIV-1-infected cells	PubMed
capsid	gag	Treatment with Torin 1, mTOR kinase inhibitor, significantly downregulates HIV-1 p24 levels in HIV-1-infected primary CD4+ T cells, Jurkat cells, and MOLT-X4 cells, suggesting mTOR kinase regulates HIV-1 production	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH25957 (e-PCR)
- UniSTS:87618

SHGC-74210 (e-PCR)
- UniSTS:33870

SHGC-12595 (e-PCR)
- UniSTS:31326

SHGC-56461 (e-PCR)
- UniSTS:6014

G60245 (e-PCR)
- UniSTS:137353

G60252 (e-PCR)
- UniSTS:137359

SHGC-132097 (e-PCR)
- UniSTS:170644

SHGC-132902 (e-PCR)
- UniSTS:183199

SHGC-79836 (e-PCR)
- UniSTS:96193

SHGC-74211 (e-PCR)
- UniSTS:63173

SHGC-74214 (e-PCR)
- UniSTS:68329

MARC_21302-21303:1032900670:1 (e-PCR)
- UniSTS:268525

SHGC-74243 (e-PCR)
- UniSTS:3313

D1S1298 (e-PCR)
- UniSTS:149495

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase III type 1 promoter sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase III type 2 promoter sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase III type 3 promoter sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables TFIIIC-class transcription factor complex binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables inositol hexakisphosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables phosphoprotein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	EXP Inferred from Experiment more info	PubMed
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein serine/threonine kinase activity	TAS Traceable Author Statement more info
enables protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables ribosome binding	IDA Inferred from Direct Assay more info	PubMed
enables ribosome binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 'de novo' pyrimidine nucleobase biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in DNA damage response	NAS Non-traceable Author Statement more info	PubMed
involved_in T cell costimulation	TAS Traceable Author Statement more info
involved_in T-helper 1 cell lineage commitment	IEA Inferred from Electronic Annotation more info
involved_in TOR signaling	IEA Inferred from Electronic Annotation more info
involved_in TOR signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in TOR signaling	NAS Non-traceable Author Statement more info	PubMed
involved_in TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in TORC1 signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in TORC1 signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in TORC2 signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in TORC2 signaling	IEA Inferred from Electronic Annotation more info
involved_in TORC2 signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in anoikis	NAS Non-traceable Author Statement more info	PubMed
involved_in behavioral response to pain	IEA Inferred from Electronic Annotation more info
acts_upstream_of calcineurin-NFAT signaling cascade	IEA Inferred from Electronic Annotation more info
involved_in cardiac cell development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cardiac muscle cell development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cardiac muscle contraction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cardiac muscle tissue development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell projection organization	IEA Inferred from Electronic Annotation more info
involved_in cellular response to L-leucine	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to amino acid starvation	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to amino acid stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hypoxia	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to hypoxia	NAS Non-traceable Author Statement more info	PubMed
involved_in cellular response to insulin stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to insulin stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to leucine starvation	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to methionine	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to nutrient	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to nutrient levels	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to nutrient levels	IEA Inferred from Electronic Annotation more info
involved_in cellular response to nutrient levels	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to nutrient levels	NAS Non-traceable Author Statement more info	PubMed
involved_in cellular response to osmotic stress	NAS Non-traceable Author Statement more info	PubMed
involved_in cellular response to starvation	IDA Inferred from Direct Assay more info	PubMed
involved_in cytoskeleton organization	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within energy reserve metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within germ cell development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heart morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heart valve morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of macroautophagy	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organism growth	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of autophagy	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of autophagy	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of autophagy	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of autophagy	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within negative regulation of calcineurin-NFAT signaling cascade	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of cell size	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of insulin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of lysosome organization	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of macroautophagy	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of macroautophagy	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of macroautophagy	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein localization to nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in neuronal action potential	IEA Inferred from Electronic Annotation more info
acts_upstream_of oligodendrocyte differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of actin filament polymerization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell growth	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of cytoplasmic translational initiation	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of epithelial to mesenchymal transition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of glycolytic process	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of keratinocyte migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of lamellipodium assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of lipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of lipid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of lipid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of lipid biosynthetic process	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within positive regulation of myotube differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of oligodendrocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of pentose-phosphate shunt	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	TAS Traceable Author Statement more info
acts_upstream_of_or_within positive regulation of stress fiber assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase III	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription of nucleolar large rRNA by RNA polymerase I	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of translation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of translational initiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of positive regulation of ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of wound healing, spreading of epidermal cells	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within post-embryonic development	IEA Inferred from Electronic Annotation more info
involved_in protein destabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in protein stabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of autophagosome assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of autophagy	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell growth	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cellular component organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of cellular response to heat	TAS Traceable Author Statement more info
involved_in regulation of cellular response to stress	IEA Inferred from Electronic Annotation more info
involved_in regulation of circadian rhythm	IEA Inferred from Electronic Annotation more info
involved_in regulation of circadian rhythm	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of locomotor rhythm	IEA Inferred from Electronic Annotation more info
involved_in regulation of locomotor rhythm	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of lysosome organization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of macroautophagy	TAS Traceable Author Statement more info
acts_upstream_of_or_within regulation of membrane permeability	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of myelination	IEA Inferred from Electronic Annotation more info
involved_in regulation of osteoclast differentiation	IEA Inferred from Electronic Annotation more info
involved_in regulation of osteoclast differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein metabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of signal transduction by p53 class mediator	TAS Traceable Author Statement more info
involved_in response to amino acid	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to amino acid	IEA Inferred from Electronic Annotation more info
involved_in response to heat	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to insulin	IEA Inferred from Electronic Annotation more info
involved_in response to nutrient levels	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to virus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ruffle organization	IEA Inferred from Electronic Annotation more info
involved_in vascular endothelial cell response to laminar fluid shear stress	TAS Traceable Author Statement more info
acts_upstream_of_or_within voluntary musculoskeletal movement	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
colocalizes_with PML body	IEA Inferred from Electronic Annotation more info
located_in PML body	IEA Inferred from Electronic Annotation more info
colocalizes_with PML body	ISS Inferred from Sequence or Structural Similarity more info
part_of TORC1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of TORC1 complex	IDA Inferred from Direct Assay more info	PubMed
part_of TORC1 complex	IEA Inferred from Electronic Annotation more info
part_of TORC1 complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of TORC1 complex	IPI Inferred from Physical Interaction more info	PubMed
part_of TORC2 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of TORC2 complex	IDA Inferred from Direct Assay more info	PubMed
part_of TORC2 complex	IEA Inferred from Electronic Annotation more info
part_of TORC2 complex	IPI Inferred from Physical Interaction more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	TAS Traceable Author Statement more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in endomembrane system	IDA Inferred from Direct Assay more info	PubMed
is_active_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	HDA more info	PubMed
is_active_in lysosomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in lysosomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in lysosome	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane	HDA more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in phagocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in phagocytic vesicle	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of serine/threonine protein kinase complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: serine/threonine-protein kinase mTOR

Names: FK506 binding protein 12-rapamycin associated protein 2; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP-rapamycin associated protein; FKBP12-rapamycin complex-associated protein 1; mammalian target of rapamycin; mechanistic target of rapamycin (serine/threonine kinase); rapamycin and FKBP12 target 1; rapamycin associated protein FRAP2; rapamycin target protein 1; tyrosine-protein kinase mTOR

NP_001373429.1

EC 2.7.10.2

EC 2.7.11.1

NP_001373430.1

EC 2.7.10.2

EC 2.7.11.1

NP_004949.1

EC 2.7.10.2

EC 2.7.11.1

XP_011539468.1

EC 2.7.10.2

EC 2.7.11.1

XP_016856389.1

EC 2.7.10.2

EC 2.7.11.1

XP_047272677.1

EC 2.7.10.2

EC 2.7.11.1

XP_047272680.1

EC 2.7.10.2

EC 2.7.11.1

XP_054191719.1

EC 2.7.10.2

EC 2.7.11.1

XP_054191720.1

EC 2.7.10.2

EC 2.7.11.1

XP_054191721.1

EC 2.7.10.2

EC 2.7.11.1

XP_054191722.1

EC 2.7.10.2

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_033239.1 RefSeqGene

Range

5001..161021

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_734

mRNA and Protein(s)

NM_001386500.1 → NP_001373429.1 serine/threonine-protein kinase mTOR isoform 1

Status: REVIEWED

Description

Transcript Variant: Variants 1 and 2 encode the same isoform (1).

Source sequence(s)

AL049653, AL109811, AL391561

Consensus CDS

CCDS127.1

UniProtKB/Swiss-Prot

P42345, Q4LE76, Q5TER1, Q6LE87, Q96QG3, Q9Y4I3

UniProtKB/TrEMBL

A0A8V8TRG9

Conserved Domains (2) summary

COG5032
Location:363 → 2549

TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]

sd00044
Location:655 → 681

HEAT; HEAT repeat [structural motif]
NM_001386501.1 → NP_001373430.1 serine/threonine-protein kinase mTOR isoform 2

Status: REVIEWED

Source sequence(s)

AL049653, AL109811, AL391561

UniProtKB/TrEMBL

A0A8V8TRG9

Conserved Domains (2) summary

COG5032
Location:66 → 2133

TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]

sd00044
Location:239 → 265

HEAT; HEAT repeat [structural motif]
NM_004958.4 → NP_004949.1 serine/threonine-protein kinase mTOR isoform 1

See identical proteins and their annotated locations for NP_004949.1

Status: REVIEWED

Description

Transcript Variant: Variants 1 and 2 encode the same isoform (1).

Source sequence(s)

AA725390, AB209995, BC117166, BP250183, DC403129, L34075, U88966

Consensus CDS

CCDS127.1

UniProtKB/Swiss-Prot

P42345, Q4LE76, Q5TER1, Q6LE87, Q96QG3, Q9Y4I3

UniProtKB/TrEMBL

A0A8V8TRG9

Related

ENSP00000354558.4, ENST00000361445.9

Conserved Domains (2) summary

COG5032
Location:363 → 2549

TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]

sd00044
Location:655 → 681

HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

11106535..11262551 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017000900.1 → XP_016856389.1 serine/threonine-protein kinase mTOR isoform X2

UniProtKB/TrEMBL

A0A8V8TRG9
XM_047416724.1 → XP_047272680.1 serine/threonine-protein kinase mTOR isoform X3
XM_047416721.1 → XP_047272677.1 serine/threonine-protein kinase mTOR isoform X1

UniProtKB/TrEMBL

A0A8V8TQN3
XM_011541166.3 → XP_011539468.1 serine/threonine-protein kinase mTOR isoform X4

UniProtKB/TrEMBL

A0A8V8TQ52, A0A8V8TQM6

Related

ENSP00000515198.1, ENST00000703141.1

Conserved Domains (3) summary

COG5032
Location:363 → 1587

TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]

pfam11865
Location:854 → 1024

DUF3385; Domain of unknown function (DUF3385)

sd00044
Location:655 → 681

HEAT; HEAT repeat [structural motif]

RNA

XR_007058581.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

NC_060925.1 Alternate T2T-CHM13v2.0

Range

10648106..10804142 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054335745.1 → XP_054191720.1 serine/threonine-protein kinase mTOR isoform X2

UniProtKB/TrEMBL

A0A8V8TRG9
XM_054335746.1 → XP_054191721.1 serine/threonine-protein kinase mTOR isoform X3
XM_054335744.1 → XP_054191719.1 serine/threonine-protein kinase mTOR isoform X1

UniProtKB/TrEMBL

A0A8V8TQN3
XM_054335747.1 → XP_054191722.1 serine/threonine-protein kinase mTOR isoform X4

UniProtKB/TrEMBL

A0A8V8TQ52, A0A8V8TQM6