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Rb1 RB transcriptional corepressor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24708, updated on 23-Jun-2022

Summary

Official Symbol
Rb1provided by RGD
Official Full Name
RB transcriptional corepressor 1provided by RGD
Primary source
RGD:3540
See related
Ensembl:ENSRNOG00000016029 AllianceGenome:RGD:3540
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including disordered domain specific binding activity; enzyme binding activity; and importin-alpha family protein binding activity. Involved in several processes, including negative regulation of apoptotic process; negative regulation of protein kinase activity; and spermatogenesis. Located in nucleus. Biomarker of acute kidney failure. Human ortholog(s) of this gene implicated in nervous system cancer (multiple); osteosarcoma; prostate cancer; small cell carcinoma; and urinary bladder cancer. Orthologous to human RB1 (RB transcriptional corepressor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 222.8), Thymus (RPKM 195.4) and 9 other tissues See more
Orthologs
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Genomic context

See Rb1 in Genome Data Viewer
Location:
15q11
Exon count:
28
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (48371295..48502473, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (55081582..55209060, complement)

Chromosome 15 - NC_051350.1Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L40, pseudogene 2 Neighboring gene uncharacterized LOC120097036 Neighboring gene RCC1 and BTB domain containing protein 2 Neighboring gene lysophosphatidic acid receptor 6 Neighboring gene integral membrane protein 2B Neighboring gene tRNA-yW synthesizing protein 5, pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables disordered domain specific binding IEA
Inferred from Electronic Annotation
more info
 
enables disordered domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables importin-alpha family protein binding IEA
Inferred from Electronic Annotation
more info
 
enables importin-alpha family protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables phosphoprotein binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphoprotein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in aortic valve morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in aortic valve morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division ISO
Inferred from Sequence Orthology
more info
 
involved_in cell morphogenesis involved in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell morphogenesis involved in neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell morphogenesis involved in neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to insulin stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in chondrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in chondrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in digestive tract development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within digestive tract development ISO
Inferred from Sequence Orthology
more info
 
involved_in enucleate erythrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within enucleate erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in glial cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within glial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in glial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of glial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in hepatocyte apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within hepatocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in heterochromatin assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in heterochromatin assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in maintenance of mitotic sister chromatid cohesion IEA
Inferred from Electronic Annotation
more info
 
involved_in maintenance of mitotic sister chromatid cohesion ISO
Inferred from Sequence Orthology
more info
 
involved_in myoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in myoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in myoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell growth IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell growth ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cold-induced thermogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in negative regulation of epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of glial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of glial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of hepatocyte apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of myofibroblast differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of myofibroblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of smoothened signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of tau-protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription involved in G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription involved in G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron maturation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within neuron maturation ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neuron projection development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of collagen fibril organization IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of collagen fibril organization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of extracellular matrix organization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of macrophage differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of macrophage differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitotic metaphase/anaphase transition IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of mitotic metaphase/anaphase transition ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription regulatory region DNA binding IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
involved_in protein localization to chromosome, centromeric region ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cohesin loading IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cohesin loading ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of lipid kinase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of lipid kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of lipid kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in sister chromatid biorientation IEA
Inferred from Electronic Annotation
more info
 
involved_in sister chromatid biorientation ISO
Inferred from Sequence Orthology
more info
 
involved_in skeletal muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within skeletal muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in smoothened signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in spermatogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in striated muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within striated muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in tissue homeostasis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within tissue homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in PML body IEA
Inferred from Electronic Annotation
more info
 
located_in PML body ISO
Inferred from Sequence Orthology
more info
 
located_in PML body ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of Rb-E2F complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of Rb-E2F complex IEA
Inferred from Electronic Annotation
more info
 
part_of Rb-E2F complex ISO
Inferred from Sequence Orthology
more info
 
part_of Rb-E2F complex ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of chromatin lock complex IEA
Inferred from Electronic Annotation
more info
 
part_of chromatin lock complex ISO
Inferred from Sequence Orthology
more info
 
part_of cyclin/CDK positive transcription elongation factor complex IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in spindle IEA
Inferred from Electronic Annotation
more info
 
located_in spindle ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
retinoblastoma-associated protein
Names
Retinoblastoma 1 (including osteosarcoma)
pRb
pp105

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017045.2NP_058741.2  retinoblastoma-associated protein

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000272
    Related
    ENSRNOP00000021752.6, ENSRNOT00000021752.6
    Conserved Domains (4) summary
    pfam01858
    Location:366566
    RB_A; Retinoblastoma-associated protein A domain
    pfam08934
    Location:760917
    Rb_C; Rb C-terminal domain
    pfam11934
    Location:108218
    DUF3452; Domain of unknown function (DUF3452)
    cd20599
    Location:637763
    CYCLIN_RB; cyclin box found in retinoblastoma-associated protein (RB) and similar proteins

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051350.1 Reference mRatBN7.2 Primary Assembly

    Range
    48371295..48502473 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039092994.1XP_038948922.1  retinoblastoma-associated protein isoform X1

    Conserved Domains (2) summary
    pfam01858
    Location:366556
    RB_A; Retinoblastoma-associated protein A domain
    pfam11934
    Location:108218
    DUF3452; Domain of unknown function (DUF3452)

RNA

  1. XR_005493691.1 RNA Sequence