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Raf1 Raf-1 proto-oncogene, serine/threonine kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 24703, updated on 10-Jul-2024

Summary

Official Symbol
Raf1provided by RGD
Official Full Name
Raf-1 proto-oncogene, serine/threonine kinaseprovided by RGD
Primary source
RGD:3531
See related
EnsemblRapid:ENSRNOG00000010153 AllianceGenome:RGD:3531
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables several functions, including ATP binding activity; adenylate cyclase activator activity; and enzyme binding activity. Involved in several processes, including MAPK cascade; protein phosphorylation; and response to hypoxia. Located in cytoplasm and plasma membrane. Biomarker of pancreatic carcinoma. Human ortholog(s) of this gene implicated in Noonan syndrome (multiple); Noonan syndrome with multiple lentigines 2; adenocarcinoma (multiple); and dilated cardiomyopathy 1NN. Orthologous to human RAF1 (Raf-1 proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 405.4), Heart (RPKM 314.2) and 9 other tissues See more
Orthologs
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Genomic context

See Raf1 in Genome Data Viewer
Location:
4q42
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (150352158..150412813, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (148679534..148740265, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (147532040..147592769, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene tRNA splicing endonuclease subunit 2 Neighboring gene MKRN2 opposite strand Neighboring gene makorin, ring finger protein, 2 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene transmembrane protein 40

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables MAP kinase kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables MAP kinase kinase kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables MAP kinase kinase kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables MAP kinase kinase kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables MAP kinase kinase kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables MAP kinase kinase kinase activity TAS
Traceable Author Statement
more info
PubMed 
enables adenylate cyclase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables adenylate cyclase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables mitogen-activated protein kinase kinase binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
 
NOT enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in ERBB2-ERBB3 signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in ERBB2-ERBB3 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in Schwann cell development IEA
Inferred from Electronic Annotation
more info
 
involved_in Schwann cell development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in death-inducing signaling complex assembly IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within death-inducing signaling complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in extrinsic apoptotic signaling pathway via death domain receptors IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
 
involved_in face development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within face development ISO
Inferred from Sequence Orthology
more info
 
involved_in heart development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in insulin secretion involved in cellular response to glucose stimulus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within insulin secretion involved in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in insulin-like growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in insulin-like growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in intermediate filament cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within intermediate filament cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within intracellular glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular signal transduction TAS
Traceable Author Statement
more info
PubMed 
involved_in myelination IEA
Inferred from Electronic Annotation
more info
 
involved_in myelination ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein-containing complex assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in neurotrophin TRK receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within neurotrophin TRK receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to muscle stretch IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within response to muscle stretch ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in somatic stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within somatic stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
 
involved_in thymus development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within thymus development ISO
Inferred from Sequence Orthology
more info
 
involved_in thyroid gland development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within thyroid gland development ISO
Inferred from Sequence Orthology
more info
 
involved_in type B pancreatic cell proliferation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_positive_effect type B pancreatic cell proliferation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in pseudopodium IEA
Inferred from Electronic Annotation
more info
 
located_in pseudopodium ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
RAF proto-oncogene serine/threonine-protein kinase
Names
C-RAF
cRaf
murine leukemia viral (v-raf-1) oncogene homolog 1 (3611-MSV)
proto-oncogene c-RAF
v-raf-1 murine leukemia viral oncogene homolog 1
v-raf-leukemia viral oncogene 1
NP_036771.1
XP_008761439.1
XP_008761440.1
XP_038962984.1
XP_038962985.1
XP_063141628.1
XP_063141629.1
XP_063141630.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012639.2NP_036771.1  RAF proto-oncogene serine/threonine-protein kinase

    See identical proteins and their annotated locations for NP_036771.1

    Status: PROVISIONAL

    Source sequence(s)
    BC062071
    UniProtKB/Swiss-Prot
    P11345
    UniProtKB/TrEMBL
    A0A8L2Q6F4, A6IKZ0
    Related
    ENSRNOP00000013831.7, ENSRNOT00000013831.8
    Conserved Domains (3) summary
    cd14149
    Location:336618
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    cd17135
    Location:55131
    RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
    cd20870
    Location:136187
    C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    150352158..150412813 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008763217.2XP_008761439.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

    See identical proteins and their annotated locations for XP_008761439.1

    UniProtKB/TrEMBL
    A0A8I5ZWZ7, A0A8L2Q6F4
    Related
    ENSRNOP00000082418.1, ENSRNOT00000105918.2
    Conserved Domains (3) summary
    cd14149
    Location:356638
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    cd17135
    Location:55131
    RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
    cd20870
    Location:136187
    C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins
  2. XM_063285558.1XP_063141628.1  RAF proto-oncogene serine/threonine-protein kinase isoform X2

    UniProtKB/Swiss-Prot
    P11345
    UniProtKB/TrEMBL
    A0A8L2Q6F4, A6IKZ0
  3. XM_039107056.2XP_038962984.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZWZ7, A0A8L2Q6F4
    Conserved Domains (3) summary
    cd14149
    Location:356638
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    cd17135
    Location:55131
    RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
    cd20870
    Location:136187
    C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins
  4. XM_008763218.4XP_008761440.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

    See identical proteins and their annotated locations for XP_008761440.1

    UniProtKB/TrEMBL
    A0A8I5ZWZ7, A0A8L2Q6F4
    Conserved Domains (3) summary
    cd14149
    Location:356638
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    cd17135
    Location:55131
    RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
    cd20870
    Location:136187
    C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins
  5. XM_039107057.2XP_038962985.1  RAF proto-oncogene serine/threonine-protein kinase isoform X2

    UniProtKB/Swiss-Prot
    P11345
    UniProtKB/TrEMBL
    A0A8L2Q6F4, A6IKZ0
    Conserved Domains (3) summary
    cd14149
    Location:336618
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    cd17135
    Location:55131
    RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
    cd20870
    Location:136187
    C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins
  6. XM_063285560.1XP_063141630.1  RAF proto-oncogene serine/threonine-protein kinase isoform X4

    UniProtKB/TrEMBL
    A0A8L2Q6F4
  7. XM_063285559.1XP_063141629.1  RAF proto-oncogene serine/threonine-protein kinase isoform X3

    UniProtKB/TrEMBL
    A0A8L2Q6F4