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ALOX15B arachidonate 15-lipoxygenase type B [ Homo sapiens (human) ]

Gene ID: 247, updated on 23-Nov-2021

Summary

Official Symbol
ALOX15Bprovided by HGNC
Official Full Name
arachidonate 15-lipoxygenase type Bprovided by HGNC
Primary source
HGNC:HGNC:434
See related
Ensembl:ENSG00000179593 MIM:603697
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
15-LOX-2
Summary
This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Expression
Biased expression in prostate (RPKM 42.3), esophagus (RPKM 13.5) and 2 other tissues See more
Orthologs
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Genomic context

See ALOX15B in Genome Data Viewer
Location:
17p13.1
Exon count:
14
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (8039059..8049134)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7942377..7952452)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371517 Neighboring gene guanylate cyclase 2D, retinal Neighboring gene arachidonate lipoxygenase 3 pseudogene 1 Neighboring gene uncharacterized LOC107985075 Neighboring gene arachidonate 12-lipoxygenase, 12R type

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in apoptotic process TAS
Traceable Author Statement
more info
PubMed 
involved_in arachidonic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in arachidonic acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cannabinoid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in endocannabinoid signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in hepoxilin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in hepoxilin biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in linoleic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in lipid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lipid metabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in lipid oxidation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in lipoxin A4 biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lipoxygenase pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell migration TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of growth IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phospholipid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of chemokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of keratinocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of macrophage derived foam cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of peroxisome proliferator activated receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in prostate gland development NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of epithelial cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in adherens junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in extrinsic component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
polyunsaturated fatty acid lipoxygenase ALOX15B
Names
15-LOX-B
15S-lipoxygenase
arachidonate 15-lipoxygenase 2
arachidonate 15-lipoxygenase type II
arachidonate 15-lipoxygenase, second type
arachidonate omega(6) lipoxygenase
linoleate 13-lipoxygenase 15-LOb
NP_001034219.1
NP_001034220.1
NP_001132.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029482.1 RefSeqGene

    Range
    5020..15095
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001039130.2NP_001034219.1  polyunsaturated fatty acid lipoxygenase ALOX15B isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (a) lacks an exon in the 3' coding region but maintains the reading frame, compared to variant d. The encoded isoform (a) is shorter than isoform d.
    Source sequence(s)
    AF468052, BC063647, BP327830, CA307212, CA405703
    Consensus CDS
    CCDS32558.1
    UniProtKB/Swiss-Prot
    O15296
    Related
    ENSP00000369520.2, ENST00000380173.6
    Conserved Domains (2) summary
    cd01753
    Location:2121
    PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
    pfam00305
    Location:232638
    Lipoxygenase; Lipoxygenase
  2. NM_001039131.2NP_001034220.1  polyunsaturated fatty acid lipoxygenase ALOX15B isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (b) has multiple differences in the coding region but maintains the reading frame, compared to variant d. The encoded isoform (b) is shorter than isoform d.
    Source sequence(s)
    AF468053, BC063647, BP327830, CA307212, CA405703
    Consensus CDS
    CCDS32559.1
    UniProtKB/Swiss-Prot
    O15296
    Related
    ENSP00000460332.2, ENST00000573359.1
    Conserved Domains (2) summary
    cd01753
    Location:2121
    PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
    pfam00305
    Location:232593
    Lipoxygenase; Lipoxygenase
  3. NM_001141.3NP_001132.2  polyunsaturated fatty acid lipoxygenase ALOX15B isoform d

    See identical proteins and their annotated locations for NP_001132.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (d) represents the longest transcript and encodes the longest isoform (d).
    Source sequence(s)
    AF468051, BC063647, BP327830, CA307212, CA405703
    Consensus CDS
    CCDS11128.1
    UniProtKB/Swiss-Prot
    O15296
    Related
    ENSP00000369530.4, ENST00000380183.9
    Conserved Domains (2) summary
    cd01753
    Location:2121
    PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
    pfam00305
    Location:232667
    Lipoxygenase; Lipoxygenase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    8039059..8049134
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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