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Ptprc protein tyrosine phosphatase, receptor type, C [ Rattus norvegicus (Norway rat) ]

Gene ID: 24699, updated on 22-Nov-2020

Summary

Official Symbol
Ptprcprovided by RGD
Official Full Name
protein tyrosine phosphatase, receptor type, Cprovided by RGD
Primary source
RGD:3451
See related
Ensembl:ENSRNOG00000000655
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Lca; RT7; CD45; L-CA; T200
Summary
member of a family of heavily glycosylated leukocyte cell surface glycoproteins; displays extensive O-glycosylation [RGD, Feb 2006]
Expression
Biased expression in Spleen (RPKM 1284.0), Thymus (RPKM 1219.5) and 4 other tissues See more
Orthologs
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Genomic context

See Ptprc in Genome Data Viewer
Location:
13q13
Exon count:
34
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (55061561..55174150, complement)
106 current Rn_Celera (GCF_000002265.2) 13 AC_000081.1 (49881478..49993142, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 13 NC_005112.3 (60094038..60205773, complement)

Chromosome 13 - NC_005112.4Genomic Context describing neighboring genes Neighboring gene microRNA 181a-1 Neighboring gene microRNA 181b-1 Neighboring gene microRNA 3570 Neighboring gene uncharacterized LOC102548579 Neighboring gene ATPase H+ transporting V1 subunit G3

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ankyrin binding ISO
Inferred from Sequence Orthology
more info
 
heparan sulfate proteoglycan binding ISO
Inferred from Sequence Orthology
more info
 
heparin binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein kinase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein kinase regulator activity TAS
Traceable Author Statement
more info
PubMed 
protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein tyrosine phosphatase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
protein tyrosine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
spectrin binding ISO
Inferred from Sequence Orthology
more info
 
transmembrane receptor protein tyrosine phosphatase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
B cell differentiation ISO
Inferred from Sequence Orthology
more info
 
B cell proliferation ISO
Inferred from Sequence Orthology
more info
 
B cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
B cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
B cell receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
T cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
T cell receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
T cell receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
activation of MAPK activity ISO
Inferred from Sequence Orthology
more info
 
bone marrow development ISO
Inferred from Sequence Orthology
more info
 
calcium-mediated signaling using intracellular calcium source ISO
Inferred from Sequence Orthology
more info
 
cell cycle phase transition ISO
Inferred from Sequence Orthology
more info
 
cellular response to extracellular stimulus ISO
Inferred from Sequence Orthology
more info
 
defense response to virus ISO
Inferred from Sequence Orthology
more info
 
defense response to virus ISS
Inferred from Sequence or Structural Similarity
more info
 
dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
hematopoietic progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
 
heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
leukocyte cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
natural killer cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
negative regulation of T cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of T cell mediated cytotoxicity ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell adhesion involved in substrate-bound cell migration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cytokine-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of interleukin-2 production ISO
Inferred from Sequence Orthology
more info
 
negative regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
negative thymic T cell selection ISO
Inferred from Sequence Orthology
more info
 
peptidyl-tyrosine dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
plasma membrane raft distribution ISO
Inferred from Sequence Orthology
more info
 
positive regulation of B cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of T cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of T cell mediated immunity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of T cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of alpha-beta T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of antigen receptor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of antigen receptor-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gamma-delta T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of hematopoietic stem cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of humoral immune response mediated by circulating immunoglobulin ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-2 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of isotype switching to IgG isotypes ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-tyrosine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of stem cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
positive thymic T cell selection ISO
Inferred from Sequence Orthology
more info
 
protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
protein dephosphorylation TAS
Traceable Author Statement
more info
PubMed 
regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
regulation of cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
regulation of humoral immune response mediated by circulating immunoglobulin ISO
Inferred from Sequence Orthology
more info
 
regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
regulation of phagocytosis ISO
Inferred from Sequence Orthology
more info
 
regulation of protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
regulation of receptor signaling pathway via JAK-STAT ISO
Inferred from Sequence Orthology
more info
 
release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
 
release of sequestered calcium ion into cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
response to gamma radiation IDA
Inferred from Direct Assay
more info
PubMed 
stem cell development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
bleb ISO
Inferred from Sequence Orthology
more info
 
cell periphery ISO
Inferred from Sequence Orthology
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cell surface ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic side of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
focal adhesion ISO
Inferred from Sequence Orthology
more info
 
focal adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane microdomain ISO
Inferred from Sequence Orthology
more info
 
membrane raft ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
receptor-type tyrosine-protein phosphatase C
Names
T200 glycoprotein
leucocyte common antigen
leukocyte common antigen A
leukocyte common antigen B
protein tyrosine phosphatase, receptor-type, c polypeptide
NP_001103357.1
NP_001103358.1
NP_001103359.1
NP_001103360.1
NP_612516.2
XP_006249972.1
XP_006249974.1
XP_008767756.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109887.2NP_001103357.1  receptor-type tyrosine-protein phosphatase C isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two in-frame exons compared to variant 4. The resulting isoform (3) is shorter compared to isoform 4.
    Source sequence(s)
    AABR07021058, AABR07021060
    UniProtKB/Swiss-Prot
    P04157
    Related
    ENSRNOP00000030503.4, ENSRNOT00000029878.6
    Conserved Domains (5) summary
    smart00194
    Location:538797
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:566797
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:283348
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12453
    Location:527
    PTP_N; Protein tyrosine phosphatase N terminal
    pfam12567
    Location:120174
    CD45; Leukocyte receptor CD45
  2. NM_001109888.2NP_001103358.1  receptor-type tyrosine-protein phosphatase C isoform 5 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks two in-frame exons compared to variant 4. The resulting isoform (5) is shorter compared to isoform 4.
    Source sequence(s)
    AABR07021058, AABR07021060
    UniProtKB/Swiss-Prot
    P04157
    Related
    ENSRNOP00000029889.4, ENSRNOT00000029865.6
    Conserved Domains (5) summary
    smart00194
    Location:531790
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:559790
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:276341
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12453
    Location:527
    PTP_N; Protein tyrosine phosphatase N terminal
    pfam12567
    Location:113167
    CD45; Leukocyte receptor CD45
  3. NM_001109889.2NP_001103359.1  receptor-type tyrosine-protein phosphatase C isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two in-frame exons compared to variant 4. The resulting isoform (2) is shorter compared to isoform 4.
    Source sequence(s)
    AABR07021058, AABR07021060
    UniProtKB/Swiss-Prot
    P04157
    Related
    ENSRNOP00000057042.2, ENSRNOT00000060292.4
    Conserved Domains (5) summary
    smart00194
    Location:530789
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:558789
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:275340
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12453
    Location:527
    PTP_N; Protein tyrosine phosphatase N terminal
    pfam12567
    Location:112166
    CD45; Leukocyte receptor CD45
  4. NM_001109890.2NP_001103360.1  receptor-type tyrosine-protein phosphatase C isoform 1 precursor

    See identical proteins and their annotated locations for NP_001103360.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks three in-frame exons compared to variant 4. The resulting isoform (1) is shorter compared to isoform 4.
    Source sequence(s)
    AABR07021058, AABR07021060
    UniProtKB/Swiss-Prot
    P04157
    Related
    ENSRNOP00000000814.4, ENSRNOT00000000814.4
    Conserved Domains (5) summary
    smart00194
    Location:489748
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:517748
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:234299
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12453
    Location:527
    PTP_N; Protein tyrosine phosphatase N terminal
    pfam12567
    Location:71125
    CD45; Leukocyte receptor CD45
  5. NM_138507.3NP_612516.2  receptor-type tyrosine-protein phosphatase C isoform 4 precursor

    See identical proteins and their annotated locations for NP_612516.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (4).
    Source sequence(s)
    AABR07021058, AABR07021060
    UniProtKB/Swiss-Prot
    P04157
    Related
    ENSRNOP00000063859.1, ENSRNOT00000064785.3
    Conserved Domains (5) summary
    smart00194
    Location:621880
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:649880
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:366431
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12453
    Location:527
    PTP_N; Protein tyrosine phosphatase N terminal
    pfam12567
    Location:203257
    CD45; Leukocyte receptor CD45

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005112.4 Reference Rnor_6.0 Primary Assembly

    Range
    55061561..55174150 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006249910.2XP_006249972.1  receptor-type tyrosine-protein phosphatase C isoform X1

    See identical proteins and their annotated locations for XP_006249972.1

    UniProtKB/Swiss-Prot
    P04157
    Conserved Domains (5) summary
    smart00194
    Location:621880
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:649880
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:366431
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12453
    Location:527
    PTP_N; Protein tyrosine phosphatase N terminal
    pfam12567
    Location:203257
    CD45; Leukocyte receptor CD45
  2. XM_006249912.3XP_006249974.1  receptor-type tyrosine-protein phosphatase C isoform X3

    Conserved Domains (6) summary
    PHA03255
    Location:22149
    PHA03255; BDLF3; Provisional
    smart00194
    Location:579838
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:607838
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:324389
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12453
    Location:527
    PTP_N; Protein tyrosine phosphatase N terminal
    pfam12567
    Location:161215
    CD45; Leukocyte receptor CD45
  3. XM_008769534.2XP_008767756.1  receptor-type tyrosine-protein phosphatase C isoform X2

    Conserved Domains (6) summary
    PHA03255
    Location:11152
    PHA03255; BDLF3; Provisional
    smart00194
    Location:580839
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:608839
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:325390
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12453
    Location:527
    PTP_N; Protein tyrosine phosphatase N terminal
    pfam12567
    Location:162216
    CD45; Leukocyte receptor CD45

Alternate Rn_Celera

Genomic

  1. AC_000081.1 Alternate Rn_Celera

    Range
    49881478..49993142 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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