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Prl prolactin [ Rattus norvegicus (Norway rat) ]

Gene ID: 24683, updated on 8-Dec-2022

Summary

Official Symbol
Prlprovided by RGD
Official Full Name
prolactinprovided by RGD
Primary source
RGD:3403
See related
Ensembl:ENSRNOG00000017374 AllianceGenome:RGD:3403
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gha1; PRLB; Prol; PRLSD1; Prl1a1; RNPROL; RATPRLSD1
Summary
Predicted to enable hormone activity and prolactin receptor binding activity. Involved in several processes, including parturition; response to estradiol; and response to lipopolysaccharide. Located in extracellular region and secretory granule. Used to study portal hypertension and prolactinoma. Biomarker of hyperprolactinemia; prolactinoma; and renovascular hypertension. Human ortholog(s) of this gene implicated in carotid artery disease. Orthologous to human PRL (prolactin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 6.5) See more
Orthologs
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Genomic context

See Prl in Genome Data Viewer
Location:
17p12
Exon count:
5
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (37859999..37870062, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (39814236..39824299, complement)

Chromosome 17 - NC_051352.1Genomic Context describing neighboring genes Neighboring gene protein phosphatase 2 catalytic subunit alpha, pseudogene 1 Neighboring gene prolactin family 3, subfamily D member 2 Neighboring gene ribosomal protein L19, pseudogene 10 Neighboring gene thymine-DNA glycosylase, pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 
enables hormone activity TAS
Traceable Author Statement
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables prolactin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables prolactin receptor binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to hormone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in circadian rhythm IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in female pregnancy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in lactation TAS
Traceable Author Statement
more info
PubMed 
involved_in mammary gland development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within mammary gland development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within maternal behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in multicellular organismal response to stress IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in negative regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of estrogen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of hydrogen peroxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of progesterone biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in ovulation cycle IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in parturition IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epithelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of lactation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of miRNA transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of receptor signaling pathway via JAK-STAT IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of receptor signaling pathway via JAK-STAT ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of receptor signaling pathway via JAK-STAT ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular endothelial growth factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of multicellular organism growth ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of ossification IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of receptor signaling pathway via JAK-STAT ISO
Inferred from Sequence Orthology
more info
 
involved_in response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to macrophage colony-stimulating factor IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to nutrient IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to nutrient levels IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in secretory granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in secretory granule ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
prolactin
Names
growth hormone a1
prolactin family 1, subfamily a, member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012629.1NP_036761.1  prolactin precursor

    See identical proteins and their annotated locations for NP_036761.1

    Status: PROVISIONAL

    Source sequence(s)
    AF022935
    UniProtKB/Swiss-Prot
    P01237, P70520
    UniProtKB/TrEMBL
    B5DEM6
    Related
    ENSRNOP00000023412.4, ENSRNOT00000023412.5
    Conserved Domains (1) summary
    cd10288
    Location:30226
    prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051352.1 Reference mRatBN7.2 Primary Assembly

    Range
    37859999..37870062 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006253912.2XP_006253974.1  prolactin isoform X1

    See identical proteins and their annotated locations for XP_006253974.1

    UniProtKB/TrEMBL
    B2RYT1
    Conserved Domains (1) summary
    cd10288
    Location:29225
    prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones