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Prkca protein kinase C, alpha [ Rattus norvegicus (Norway rat) ]

Gene ID: 24680, updated on 12-Jan-2022

Summary

Official Symbol
Prkcaprovided by RGD
Official Full Name
protein kinase C, alphaprovided by RGD
Primary source
RGD:3395
See related
Ensembl:ENSRNOG00000003491
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pkca
Summary
Enables calcium-dependent protein kinase C activity. Involved in several processes, including positive regulation of ERK1 and ERK2 cascade; protein phosphorylation; and regulation of vesicle-mediated transport. Located in several cellular components, including membrane raft; mitochondrion; and perinuclear region of cytoplasm. Part of protein-containing complex. Used to study hypertension. Biomarker of brain ischemia; congestive heart failure; and ischemia. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; high grade glioma (multiple); large cell carcinoma; and reproductive organ cancer (multiple). Orthologous to human PRKCA (protein kinase C alpha). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Muscle (RPKM 146.0), Brain (RPKM 140.7) and 9 other tissues See more
Orthologs
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Genomic context

See Prkca in Genome Data Viewer
Location:
10q32.1
Exon count:
19
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (92889390..93288013, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (96186509..96585168, complement)

Chromosome 10 - NC_051345.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352151 Neighboring gene calcium voltage-gated channel auxiliary subunit gamma 5 Neighboring gene centrosomal protein 112 Neighboring gene apolipoprotein H Neighboring gene uncharacterized LOC120095198

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium-dependent protein kinase C activity IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium-dependent protein kinase C activity IEA
Inferred from Electronic Annotation
more info
 
enables calcium-dependent protein kinase C activity ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding IEA
Inferred from Electronic Annotation
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables histone kinase activity (H3-T6 specific) IEA
Inferred from Electronic Annotation
more info
 
enables histone kinase activity (H3-T6 specific) ISO
Inferred from Sequence Orthology
more info
 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase C activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase C activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in aging IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to carbohydrate stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in central nervous system neuron axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within chondrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in desmosome assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in desmosome assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of protein localization TAS
Traceable Author Statement
more info
PubMed 
involved_in histone H3-T6 phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in histone H3-T6 phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within induction of positive chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in learning or memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of anion channel activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of glial cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of glial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of glial cell apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within negative regulation of glucose import ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of heart contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neutrophil chemotaxis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within peptidyl-serine autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-threonine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-threonine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of blood vessel endothelial cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of bone resorption ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cardiac muscle hypertrophy IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of dense core granule biogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dense core granule biogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of endothelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of lipopolysaccharide-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of lipopolysaccharide-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of lipopolysaccharide-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of macrophage differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of macrophage differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of synapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in presynaptic modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell communication IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of muscle contraction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of platelet aggregation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of platelet aggregation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of platelet aggregation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of receptor-mediated endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of response to osmotic stress ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of synaptic vesicle exocytosis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of the force of heart contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in response to antibiotic IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to corticosterone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to estradiol IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to ethanol IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to interleukin-1 IEA
Inferred from Electronic Annotation
more info
 
involved_in response to interleukin-1 ISO
Inferred from Sequence Orthology
more info
 
involved_in response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to peptide hormone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to reactive oxygen species IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to toxic substance IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
part_of alphav-beta3 integrin-PKCalpha complex ISO
Inferred from Sequence Orthology
more info
 
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
is_active_in calyx of Held ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in intercalated disc ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in photoreceptor outer segment ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane bounded cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in presynaptic cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein kinase C alpha type
Names
PKC-A
PKC-alpha
XP_017452495.2
XP_017452496.2
XP_038941139.1
XP_038941140.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399299.1NP_001386228.1  protein kinase C alpha type

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000220

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051345.1 Reference mRatBN7.2 Primary Assembly

    Range
    92889390..93288013 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039085211.1XP_038941139.1  protein kinase C alpha type isoform X1

    Conserved Domains (4) summary
    cd04026
    Location:159289
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    cd20833
    Location:3592
    C1_cPKC_rpt1; first protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
    cd20836
    Location:102155
    C1_cPKC_rpt2; second protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
    cl21453
    Location:328718
    PKc_like; Protein Kinases, catalytic domain
  2. XM_017597006.2XP_017452495.2  protein kinase C alpha type isoform X2

    Related
    ENSRNOP00000079110.1, ENSRNOT00000100596.1
    Conserved Domains (4) summary
    cd04026
    Location:159289
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    cd05615
    Location:328684
    STKc_cPKC_alpha; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha
    cd20833
    Location:3592
    C1_cPKC_rpt1; first protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
    cd20836
    Location:102155
    C1_cPKC_rpt2; second protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
  3. XM_039085212.1XP_038941140.1  protein kinase C alpha type isoform X4

    Conserved Domains (4) summary
    cd04026
    Location:96226
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    cd20836
    Location:3992
    C1_cPKC_rpt2; second protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
    cl00040
    Location:625
    C1; protein kinase C conserved region 1 (C1 domain) superfamily
    cl21453
    Location:265655
    PKc_like; Protein Kinases, catalytic domain
  4. XM_017597007.2XP_017452496.2  protein kinase C alpha type isoform X3

    Related
    ENSRNOP00000004699.8, ENSRNOT00000004699.9
    Conserved Domains (4) summary
    cd04026
    Location:159289
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    cd05615
    Location:328668
    STKc_cPKC_alpha; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha
    cd20833
    Location:3592
    C1_cPKC_rpt1; first protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
    cd20836
    Location:102155
    C1_cPKC_rpt2; second protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001105713.1: Suppressed sequence

    Description
    NM_001105713.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
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