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Prkar2b protein kinase cAMP-dependent type II regulatory subunit beta [ Rattus norvegicus (Norway rat) ]

Gene ID: 24679, updated on 4-Jun-2020

Summary

Official Symbol
Prkar2bprovided by RGD
Official Full Name
protein kinase cAMP-dependent type II regulatory subunit betaprovided by RGD
Primary source
RGD:3394
See related
Ensembl:ENSRNOG00000009079
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RATDNA
Summary
acts as a regulatory subunit of type II cAMP-dependent protein kinase [RGD, Feb 2006]
Expression
Biased expression in Thymus (RPKM 683.9), Adrenal (RPKM 590.0) and 7 other tissues See more
Orthologs

Genomic context

See Prkar2b in Genome Data Viewer
Location:
6q16
Exon count:
12
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (51265509..51356383, complement)
106 current Rn_Celera (GCF_000002265.2) 6 AC_000074.1 (47765297..47855503, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 6 NC_005105.3 (59936123..60027242, complement)

Chromosome 6 - NC_005105.4Genomic Context describing neighboring genes Neighboring gene component of oligomeric golgi complex 5 Neighboring gene G protein-coupled receptor 22 Neighboring gene 60S ribosomal protein L18a-like Neighboring gene HMG-box transcription factor 1 Neighboring gene phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma Neighboring gene hypothetical LOC100361355

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC116401

Gene Ontology Provided by RGD

Function Evidence Code Pubs
cAMP binding IDA
Inferred from Direct Assay
more info
PubMed 
cAMP binding IEA
Inferred from Electronic Annotation
more info
 
cAMP-dependent protein kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
cAMP-dependent protein kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cAMP-dependent protein kinase regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
cAMP-dependent protein kinase regulator activity IEA
Inferred from Electronic Annotation
more info
 
cAMP-dependent protein kinase regulator activity ISO
Inferred from Sequence Orthology
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase A catalytic subunit binding IC
Inferred by Curator
more info
PubMed 
protein kinase A catalytic subunit binding ISO
Inferred from Sequence Orthology
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
learning ISO
Inferred from Sequence Orthology
more info
 
modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cAMP-dependent protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of cAMP-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of protein kinase A signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
response to antipsychotic drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to clozapine IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
cAMP-dependent protein kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cAMP-dependent protein kinase complex IDA
Inferred from Direct Assay
more info
PubMed 
cAMP-dependent protein kinase complex IEA
Inferred from Electronic Annotation
more info
 
cAMP-dependent protein kinase complex ISO
Inferred from Sequence Orthology
more info
 
centrosome ISO
Inferred from Sequence Orthology
more info
 
ciliary base ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
dendritic shaft ISO
Inferred from Sequence Orthology
more info
 
dendritic shaft ISS
Inferred from Sequence or Structural Similarity
more info
 
dendritic spine ISO
Inferred from Sequence Orthology
more info
 
dendritic spine ISS
Inferred from Sequence or Structural Similarity
more info
 
glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
postsynapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cAMP-dependent protein kinase type II-beta regulatory subunit
Names
Type II beta regulatory subunit of cAMP-dependent protein kinase
protein kinase cAMP-dependent type 2 regulatory subunit beta
protein kinase, cAMP dependent regulatory, type II beta
protein kinase, cAMP-dependent, regulatory subunit type II beta
NP_001025191.1
XP_017449526.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001030020.1NP_001025191.1  cAMP-dependent protein kinase type II-beta regulatory subunit

    See identical proteins and their annotated locations for NP_001025191.1

    Status: VALIDATED

    Source sequence(s)
    BI298837, CB814252, CX569141, M12492
    UniProtKB/Swiss-Prot
    P12369
    Related
    ENSRNOP00000012415.6, ENSRNOT00000012415.6
    Conserved Domains (3) summary
    cd12104
    Location:343
    DD_RIIbeta_PKA; Dimerization/Docking domain of the Type II beta Regulatory subunit of cAMP-dependent protein kinase
    COG0664
    Location:268383
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:274394
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005105.4 Reference Rnor_6.0 Primary Assembly

    Range
    51265509..51356383 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017594037.1XP_017449526.1  cAMP-dependent protein kinase type II-beta regulatory subunit isoform X1

    Related
    ENSRNOP00000074658.1, ENSRNOT00000079719.1

Alternate Rn_Celera

Genomic

  1. AC_000074.1 Alternate Rn_Celera

    Range
    47765297..47855503 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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