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Il27 interleukin 27 [ Mus musculus (house mouse) ]

Gene ID: 246779, updated on 19-Feb-2024

Summary

Official Symbol
Il27provided by MGI
Official Full Name
interleukin 27provided by MGI
Primary source
MGI:MGI:2384409
See related
Ensembl:ENSMUSG00000044701 AllianceGenome:MGI:2384409
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p28; Il30; IL-27; IL27-A; IL-27-A; IL-27p28
Summary
Enables interleukin-27 receptor binding activity. Acts upstream of or within positive regulation of defense response to virus by host and regulation of T cell proliferation. Located in extracellular space. Is expressed in decidua; embryo; and extraembryonic component. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; and pulmonary tuberculosis. Orthologous to human IL27 (interleukin 27). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in genital fat pad adult (RPKM 5.8), spleen adult (RPKM 2.5) and 18 other tissues See more
Orthologs
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Genomic context

See Il27 in Genome Data Viewer
Location:
7 F3; 7 69.18 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126188181..126194197, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (126589009..126595035, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 25579 Neighboring gene CLN3 lysosomal/endosomal transmembrane protein, battenin Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:133726956-133727139 Neighboring gene microRNA 7059 Neighboring gene apolipoprotein B receptor Neighboring gene predicted gene, 39086 Neighboring gene predicted gene, 39087 Neighboring gene nuclear protein transcription regulator 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 
enables interleukin-27 receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables interleukin-27 receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
interleukin-27 subunit alpha
Names
IL-27 p28 subunit
IL-27 subunit alpha
interleukin 30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145636.2NP_663611.1  interleukin-27 subunit alpha precursor

    See identical proteins and their annotated locations for NP_663611.1

    Status: VALIDATED

    Source sequence(s)
    AC125169, AI662173, AK153466
    Consensus CDS
    CCDS21835.1
    UniProtKB/Swiss-Prot
    Q8K3I6
    Related
    ENSMUSP00000054637.6, ENSMUST00000058429.6

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    126188181..126194197 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507857.3XP_006507920.1  interleukin-27 subunit alpha isoform X1

  2. XM_036153130.1XP_036009023.1  interleukin-27 subunit alpha isoform X2