Cyp4x1 cytochrome P450, family 4, subfamily x, polypeptide 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cyp4x1provided by RGD
Official Full Name: cytochrome P450, family 4, subfamily x, polypeptide 1provided by RGD
Primary source: RGD:628719
See related: Ensembl:ENSRNOG00000043513 AllianceGenome:RGD:628719
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable anandamide 14,15 epoxidase activity. Predicted to be involved in lipid metabolic process. Predicted to be located in endoplasmic reticulum membrane. Orthologous to human CYP4X1 (cytochrome P450 family 4 subfamily X member 1). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Restricted expression toward (RPKM 67.6) See more
Orthologs: all
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Genomic context

Location:: 5q35

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (133888439..133923254, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (128651681..128683338, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (133929532..133959447, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data suggest there is circadian regulation of Cyp4x1 and Cyp2c11 gene expression, and that eicosanoid production may contribute to circadian changes in blood flow and alter the risk of adverse cardiovascular events throughout the day.
Title: Rhythmic expression of cytochrome P450 epoxygenases CYP4x1 and CYP2c11 in the rat brain and vasculature.
molecular cloning & specific localization of Cyp4x1 to the brain
Title: Identification of a novel cytochrome P450, CYP4X1, with unique localization specific to the brain.

Submit: New GeneRIF Correction

General gene information

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Markers

Cyp4x1 (e-PCR), detects polymorphism
- UniSTS:468832

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables anandamide 14,15 epoxidase activity	IEA Inferred from Electronic Annotation more info
enables anandamide 14,15 epoxidase activity	ISO Inferred from Sequence Orthology more info
enables anandamide 14,15 epoxidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: cytochrome P450 4X1

Names: CYPIVX1

NP_663708.1

EC 1.14.14.1

XP_063143232.1

EC 1.14.14.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145675.2 → NP_663708.1 cytochrome P450 4X1

See identical proteins and their annotated locations for NP_663708.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q8K4D6

UniProtKB/TrEMBL

A6JZ35, A6JZ36

Related

ENSRNOP00000011985.1, ENSRNOT00000011985.4

Conserved Domains (1) summary

cd20678
Location:66 → 500

CYP4B-like; cytochrome P450 family 4, subfamily B and similar cytochrome P450s, including subfamilies A, T, X, and Z