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Ppp3cb protein phosphatase 3 catalytic subunit beta [ Rattus norvegicus (Norway rat) ]

Gene ID: 24675, updated on 5-Sep-2021

Summary

Official Symbol
Ppp3cbprovided by RGD
Official Full Name
protein phosphatase 3 catalytic subunit betaprovided by RGD
Primary source
RGD:3383
See related
Ensembl:ENSRNOG00000054782
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Calna2
Expression
Biased expression in Brain (RPKM 499.2), Muscle (RPKM 383.8) and 9 other tissues See more
Orthologs
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Genomic context

See Ppp3cb in Genome Data Viewer
Location:
15p16
Exon count:
15
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (3759950..3804976)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (4209702..4236895)

Chromosome 15 - NC_051350.1Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 54 Neighboring gene transfer RNA threonine (anticodon AGU) Neighboring gene small nucleolar RNA SNORA68 Neighboring gene uncharacterized LOC103693236 Neighboring gene 60S ribosomal protein L15-like Neighboring gene MSS51 mitochondrial translational activator Neighboring gene annexin A7

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables calcium-dependent protein serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calmodulin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
 
enables calmodulin-dependent protein phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calmodulin-dependent protein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables calmodulin-dependent protein phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables calmodulin-dependent protein phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables protein dimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein phosphatase 2B binding IEA
Inferred from Electronic Annotation
more info
 
enables protein phosphatase 2B binding ISO
Inferred from Sequence Orthology
more info
 
enables protein phosphatase 2B binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein serine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine phosphatase activity TAS
Traceable Author Statement
more info
 
enables protein threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in T cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in T cell homeostasis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within T cell homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in brain development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in calcineurin-NFAT signaling cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in calcineurin-NFAT signaling cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in calcineurin-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in calcineurin-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in calcineurin-mediated signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in calcium-ion regulated exocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in calcium-ion regulated exocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium-ion regulated exocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in heart development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within heart development ISO
Inferred from Sequence Orthology
more info
 
involved_in locomotion involved in locomotory behavior IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within locomotion involved in locomotory behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in lymphangiogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lymphangiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in muscle cell cellular homeostasis IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in negative regulation of T cell mediated cytotoxicity IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of T cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in protein dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of insulin secretion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of synaptic vesicle endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of synaptic vesicle endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in response to amphetamine IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to cytokine IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within response to cytokine ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in T-tubule IEA
Inferred from Electronic Annotation
more info
 
located_in T-tubule ISO
Inferred from Sequence Orthology
more info
 
located_in Z disc IEA
Inferred from Electronic Annotation
more info
 
located_in Z disc ISO
Inferred from Sequence Orthology
more info
 
part_of calcineurin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of calcineurin complex IEA
Inferred from Electronic Annotation
more info
 
part_of calcineurin complex ISO
Inferred from Sequence Orthology
more info
 
part_of calcineurin complex ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
Names
CAM-PRP catalytic subunit
CNA beta
CaN Abeta
Calcineurin subunit A beta
protein phosphatase 3, catalytic subunit, beta isozyme
protein phosphatase-2Bb
NP_058738.1
XP_038948913.1
XP_038948914.1
XP_038948915.1
XP_038948916.1
XP_038948917.1
XP_038948918.1
XP_038948919.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017042.2NP_058738.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

    See identical proteins and their annotated locations for NP_058738.1

    Status: PROVISIONAL

    Source sequence(s)
    D90036
    UniProtKB/Swiss-Prot
    P20651
    Related
    ENSRNOP00000074339.1, ENSRNOT00000082236.1
    Conserved Domains (2) summary
    smart00156
    Location:67338
    PP2Ac; Protein phosphatase 2A homologues, catalytic domain
    cd07416
    Location:50354
    MPP_PP2B; PP2B, metallophosphatase domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051350.1 Reference mRatBN7.2 Primary Assembly

    Range
    3759950..3804976
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039092985.1XP_038948913.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1

    Conserved Domains (1) summary
    cd07416
    Location:50354
    MPP_PP2B; PP2B, metallophosphatase domain
  2. XM_039092989.1XP_038948917.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X5

    Conserved Domains (1) summary
    cd07416
    Location:50354
    MPP_PP2B; PP2B, metallophosphatase domain
  3. XM_039092986.1XP_038948914.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X2

    Conserved Domains (1) summary
    cd07416
    Location:50354
    MPP_PP2B; PP2B, metallophosphatase domain
  4. XM_039092990.1XP_038948918.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X6

    Conserved Domains (1) summary
    cd07416
    Location:50354
    MPP_PP2B; PP2B, metallophosphatase domain
  5. XM_039092988.1XP_038948916.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X4

    Conserved Domains (1) summary
    cd07416
    Location:50354
    MPP_PP2B; PP2B, metallophosphatase domain
  6. XM_039092991.1XP_038948919.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X7

    Conserved Domains (1) summary
    cd07416
    Location:50354
    MPP_PP2B; PP2B, metallophosphatase domain
  7. XM_039092987.1XP_038948915.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X3

    Conserved Domains (1) summary
    cd07416
    Location:50352
    MPP_PP2B; PP2B, metallophosphatase domain
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