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POLR2J2 RNA polymerase II subunit J2 [ Homo sapiens (human) ]

Gene ID: 246721, updated on 23-Nov-2021

Summary

Official Symbol
POLR2J2provided by HGNC
Official Full Name
RNA polymerase II subunit J2provided by HGNC
Primary source
HGNC:HGNC:23208
See related
MIM:609881
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HRPB11B; RPB11b1
Summary
This gene is a member of the RNA polymerase II subunit 11 gene family, which includes three genes in a cluster on chromosome 7q22.1 and a pseudogene on chromosome 7p13. The founding member of this family, DNA directed RNA polymerase II polypeptide J, has been shown to encode a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This locus produces multiple, alternatively spliced transcripts that potentially express isoforms with distinct C-termini compared to DNA directed RNA polymerase II polypeptide J. Most or all variants are spliced to include additional non-coding exons at the 3' end which makes them candidates for nonsense-mediated decay (NMD). Consequently, it is not known if this locus expresses a protein or proteins in vivo. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in esophagus (RPKM 55.4), thyroid (RPKM 33.8) and 25 other tissues See more
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Genomic context

See POLR2J2 in Genome Data Viewer
Location:
7q22.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (102666046..102671663, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (102277195..102312182, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene POLR2J2-UPK3BL1 readthrough Neighboring gene uroplakin 3B like 1 Neighboring gene speedy/RINGO cell cycle regulator family member E2B Neighboring gene RAS p21 protein activator 4D, pseudogene Neighboring gene Sharpr-MPRA regulatory region 2028 Neighboring gene family with sequence similarity 185 member A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough POLR2J2-UPK3BL1

Readthrough gene: POLR2J2-UPK3BL1, Included gene: UPK3BL1

Homology

Clone Names

  • MGC54043, MGC105050

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to DNA-directed 5'-3' RNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II activity IEA
Inferred from Electronic Annotation
more info
 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of RNA polymerase II, core complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
DNA-directed RNA polymerase II subunit RPB11-b1
Names
DNA directed RNA polymerase II polypeptide J-related
DNA-directed RNA polymerase II subunit J2
RNA polymerase II subunit B11-b1
polymerase (RNA) II (DNA directed) polypeptide J2
polymerase (RNA) II subunit J2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032959.7NP_116581.3  DNA-directed RNA polymerase II subunit RPB11-b1

    See identical proteins and their annotated locations for NP_116581.3

    Status: REVIEWED

    Source sequence(s)
    AC105052
    Consensus CDS
    CCDS43627.1
    UniProtKB/Swiss-Prot
    Q9GZM3
    Related
    ENSP00000418603.1, ENST00000476151.5
    Conserved Domains (1) summary
    cd06926
    Location:14104
    RNAP_II_RPB11; RPB11 subunit of Eukaryotic RNA polymerase II

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    102666046..102671663 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_032958.3: Suppressed sequence

    Description
    NM_032958.3: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  2. NM_145325.2: Suppressed sequence

    Description
    NM_145325.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript, and it may be a nonsense-mediated mRNA decay (NMD) candidate.
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