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Ppp2ca protein phosphatase 2 catalytic subunit alpha [ Rattus norvegicus (Norway rat) ]

Gene ID: 24672, updated on 19-Apr-2019

Summary

Official Symbol
Ppp2caprovided by RGD
Official Full Name
protein phosphatase 2 catalytic subunit alphaprovided by RGD
Primary source
RGD:3380
See related
Ensembl:ENSRNOG00000005389
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pp2a1
Summary
catalyzes the removal of serine- and threonine- bound phosphate groups [RGD, Feb 2006]
Expression
Biased expression in Brain (RPKM 901.0), Heart (RPKM 751.6) and 9 other tissues See more
Orthologs

Genomic context

See Ppp2ca in Genome Data Viewer
Location:
10q22
Exon count:
8
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (37534449..37554861, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (37324233..37343985)

Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2B Neighboring gene cyclin-dependent kinase-like 3 Neighboring gene uncharacterized LOC103693326 Neighboring gene similar to growth and transformation-dependent protein

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
GABA receptor binding ISO
Inferred from Sequence Orthology
more info
PubMed 
beta-2 adrenergic receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
ion channel binding IPI
Inferred from Physical Interaction
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein C-terminus binding ISO
Inferred from Sequence Orthology
more info
PubMed 
protein antigen binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein dimerization activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein domain specific binding IDA
Inferred from Direct Assay
more info
PubMed 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
PubMed 
protein heterodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein kinase B binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase 2A binding IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphatase 2A binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
protein serine/threonine phosphatase activity TAS
Traceable Author Statement
more info
PubMed 
protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
tau protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cardiac ventricle development IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to calcium ion IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to cytokine stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to follicle-stimulating hormone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to glucose stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to insulin stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to steroid hormone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
heart development IEP
Inferred from Expression Pattern
more info
PubMed 
meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
mesoderm development ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of calcium ion transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-threonine dephosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of microtubule binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of phosphoprotein phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein dephosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
protein dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein heterotrimerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein autophosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of signaling receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to lead ion IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
chromosome, centromeric region ISO
Inferred from Sequence Orthology
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
PubMed 
membrane raft ISO
Inferred from Sequence Orthology
more info
PubMed 
membrane raft ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphatase type 2A complex ISO
Inferred from Sequence Orthology
more info
PubMed 
spindle pole IEA
Inferred from Electronic Annotation
more info
 
synapse ISO
Inferred from Sequence Orthology
more info
PubMed 
terminal bouton IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Names
PP2A-alpha
protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform
protein phosphatase 2, catalytic subunit, alpha isoform
protein phosphatase 2, catalytic subunit, alpha isozyme
protein phosphatase 2a, catalytic subunit, alpha isoform
protein phosphatase-2A-alpha
NP_058735.1
XP_017452493.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017039.2NP_058735.1  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

    See identical proteins and their annotated locations for NP_058735.1

    Status: PROVISIONAL

    Source sequence(s)
    BC072531
    UniProtKB/Swiss-Prot
    P63331
    Related
    ENSRNOP00000007621.3, ENSRNOT00000007621.5
    Conserved Domains (1) summary
    cd07415
    Location:9293
    MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

    Range
    37534449..37554861 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017597004.1XP_017452493.1  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X1

Alternate Rn_Celera

Genomic

  1. AC_000078.1 Alternate Rn_Celera

    Range
    35713154..35732937
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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