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Ppp2ca protein phosphatase 2 catalytic subunit alpha [ Rattus norvegicus (Norway rat) ]

Gene ID: 24672, updated on 13-Jul-2024

Summary

Symbol
Ppp2caprovided by RGD
Full Name
protein phosphatase 2 catalytic subunit alphaprovided by RGD
Primary source
RGD:3380
See related
AllianceGenome:RGD:3380
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pp2a1
Summary
Enables several functions, including beta-2 adrenergic receptor binding activity; enzyme binding activity; and protein C-terminus binding activity. Involved in several processes, including cellular response to hormone stimulus; negative regulation of transport; and regulation of cellular protein metabolic process. Acts upstream of or within regulation of protein autophosphorylation; regulation of protein catabolic process; and regulation of signaling receptor activity. Located in cytosol; postsynaptic density; and terminal bouton. Part of protein phosphatase type 2A complex. Biomarker of type 2 diabetes mellitus. Orthologous to human PPP2CA (protein phosphatase 2 catalytic subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 901.0), Heart (RPKM 751.6) and 9 other tissues See more
Orthologs
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Genomic context

See Ppp2ca in Genome Data Viewer
Location:
10q22
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (36856534..36878789)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (36358110..36377864)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (37534449..37554861, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2B Neighboring gene cyclin-dependent kinase-like 3 Neighboring gene large ribosomal subunit protein eL21-like Neighboring gene protein FAM162A-like Neighboring gene small nucleolar RNA SNORA42/SNORA80 family Neighboring gene S-phase kinase-associated protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GABA receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables beta-2 adrenergic receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein antigen binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein heterodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein kinase B binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase 2A binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein phosphatase 2A binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine phosphatase activity TAS
Traceable Author Statement
more info
PubMed 
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables tau protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane transporter binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in T cell homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in T cell homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cardiac ventricle development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to calcium ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to cytokine stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to follicle-stimulating hormone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to glucose stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to insulin stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to steroid hormone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in heart development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within mesoderm development ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of glycolytic process through fructose-6-phosphate ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of hippo signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of hippo signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of NLRP3 inflammasome complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NLRP3 inflammasome complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein dephosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of protein autophosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to lead ion IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of FAR/SIN/STRIPAK complex ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, centromeric region ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in membrane raft ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein phosphatase type 2A complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of protein phosphatase type 2A complex ISO
Inferred from Sequence Orthology
more info
 
part_of protein serine/threonine phosphatase complex ISO
Inferred from Sequence Orthology
more info
 
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
 
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
 
located_in terminal bouton IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Names
PP2A-alpha
protein phosphatase 2, catalytic subunit, alpha isozyme
protein phosphatase 2A catalytic alpha subunit
protein phosphatase-2A-alpha
NP_058735.1
XP_063124487.1
XP_063124488.1
XP_063124489.1
XP_063124490.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429961.1NP_001416890.1  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8I5ZZ39
  2. NM_001429962.1NP_001416891.1  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8I5ZZ39, A0A8L2R3S5
  3. NM_017039.3NP_058735.1  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform 1

    See identical proteins and their annotated locations for NP_058735.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    P63331
    UniProtKB/TrEMBL
    A0A8I5ZZ39, A6HE97
    Conserved Domains (1) summary
    cd07415
    Location:9293
    MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    36856534..36878789
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063268417.1XP_063124487.1  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X1

  2. XM_063268420.1XP_063124490.1  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X4

  3. XM_063268418.1XP_063124488.1  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X2

  4. XM_063268419.1XP_063124489.1  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X3