Format

Send to:

Choose Destination

Pomc proopiomelanocortin [ Rattus norvegicus (Norway rat) ]

Gene ID: 24664, updated on 25-Nov-2021

Summary

Official Symbol
Pomcprovided by RGD
Official Full Name
proopiomelanocortinprovided by RGD
Primary source
RGD:3366
See related
EnsemblRapid:ENSRNOG00000012686
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pomc1; Pomc2; alphaMSH
Expression
Biased expression in Testes (RPKM 25.0), Kidney (RPKM 15.8) and 9 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Pomc in Genome Data Viewer
Location:
6q14
Exon count:
3
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (26939844..26945666)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (28382937..28388771)

Chromosome 6 - NC_051341.1Genomic Context describing neighboring genes Neighboring gene DNA methyltransferase 3 alpha Neighboring gene uncharacterized LOC120103494 Neighboring gene hypothetical gene supported by BC088468; NM_001009712 Neighboring gene EFR3 homolog B Neighboring gene uncharacterized LOC120103495 Neighboring gene DnaJ heat shock protein family (Hsp40) member C27 Neighboring gene cytochrome c oxidase subunit 7B, mitochondrial-like

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G protein-coupled receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 
enables hormone activity ISO
Inferred from Sequence Orthology
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables type 1 melanocortin receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables type 1 melanocortin receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables type 3 melanocortin receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables type 3 melanocortin receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables type 4 melanocortin receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables type 4 melanocortin receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-cell signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in cell-cell signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular pigmentation IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular pigmentation ISO
Inferred from Sequence Orthology
more info
 
involved_in cortisol secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in feeding behavior NAS
Non-traceable Author Statement
more info
PubMed 
involved_in generation of precursor metabolites and energy IEA
Inferred from Electronic Annotation
more info
 
involved_in generation of precursor metabolites and energy ISO
Inferred from Sequence Orthology
more info
 
involved_in glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in killing of cells of other organism ISO
Inferred from Sequence Orthology
more info
 
involved_in modulation of process of other organism ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of tumor necrosis factor production IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cAMP-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neutrophil mediated killing of fungus ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of oxytocin production IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of appetite IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of appetite ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of corticosterone secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of corticosterone secretion IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of corticosterone secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of glycogen metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of glycogen metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in response to immobilization stress ISO
Inferred from Sequence Orthology
more info
 
involved_in response to melanocyte-stimulating hormone IEA
Inferred from Electronic Annotation
more info
 
involved_in response to melanocyte-stimulating hormone ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in peroxisomal matrix ISO
Inferred from Sequence Orthology
more info
 
NOT located_in peroxisome ISO
Inferred from Sequence Orthology
more info
 
is_active_in secretory granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in secretory granule IEA
Inferred from Electronic Annotation
more info
 
located_in secretory granule ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
pro-opiomelanocortin
Names
alpha-melanocyte-stimulating hormone
corticotropin-lipotropin
pro-opiomelanocortin-alpha
proopiomelanocortin (adrenocorticotropin/ beta-lipotropin/ alpha-melanocyte stimulating hormone/ beta-melanocyte stimulating hormone/ beta-endorphin)
proopiomelanocortin, beta (endorphin, beta)
proopoimelanocortin, beta (endorphin, beta)

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139326.3NP_647542.1  pro-opiomelanocortin precursor

    See identical proteins and their annotated locations for NP_647542.1

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000164
    UniProtKB/TrEMBL
    Q8K422
    Related
    ENSRNOP00000016976.5, ENSRNOT00000016976.8
    Conserved Domains (3) summary
    pfam00976
    Location:186204
    ACTH_domain; Corticotropin ACTH domain
    pfam08035
    Location:205232
    Op_neuropeptide; Opioids neuropeptide
    pfam08384
    Location:2870
    NPP; Pro-opiomelanocortin, N-terminal region

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051341.1 Reference mRatBN7.2 Primary Assembly

    Range
    26939844..26945666
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017594033.2XP_017449522.1  pro-opiomelanocortin isoform X1

    UniProtKB/TrEMBL
    Q8K422
    Conserved Domains (3) summary
    pfam00976
    Location:186204
    ACTH_domain; Corticotropin ACTH domain
    pfam08035
    Location:205232
    Op_neuropeptide; Opioids neuropeptide
    pfam08384
    Location:2870
    NPP; Pro-opiomelanocortin, N-terminal region
Support Center