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Pmp22 peripheral myelin protein 22 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24660, updated on 2-Oct-2018

Summary

Official Symbol
Pmp22provided by RGD
Official Full Name
peripheral myelin protein 22provided by RGD
Primary source
RGD:3359
See related
Ensembl:ENSRNOG00000003338
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gas-3
Summary
mediates Schwann cell growth and peripheral myelin compaction; human homolog gene duplication causes Charcot-Marie-Tooth 1A (CMT1A) neuropathy [RGD, Feb 2006]
Expression
Biased expression in Lung (RPKM 789.0), Muscle (RPKM 646.4) and 8 other tissues See more
Orthologs

Genomic context

See Pmp22 in Genome Data Viewer
Location:
10q23
Exon count:
6
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (49538588..49568583)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (49317000..49346995)

Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene CMT1A duplicated region transcript 4 Neighboring gene tektin 3 Neighboring gene uncharacterized LOC108352093 Neighboring gene ubiquitin B-like

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
motor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
Schwann cell development ISO
Inferred from Sequence Orthology
more info
 
Schwann cell differentiation ISO
Inferred from Sequence Orthology
more info
 
Schwann cell migration ISO
Inferred from Sequence Orthology
more info
 
actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
adult locomotory behavior ISO
Inferred from Sequence Orthology
more info
 
adult walking behavior ISO
Inferred from Sequence Orthology
more info
 
aggresome assembly ISO
Inferred from Sequence Orthology
more info
 
autophagy ISO
Inferred from Sequence Orthology
more info
 
axon development ISO
Inferred from Sequence Orthology
more info
 
basement membrane organization ISO
Inferred from Sequence Orthology
more info
 
bleb assembly IEA
Inferred from Electronic Annotation
more info
 
bleb assembly ISO
Inferred from Sequence Orthology
more info
 
cell adhesion ISO
Inferred from Sequence Orthology
more info
 
cell cycle arrest IEA
Inferred from Electronic Annotation
more info
 
cell death IEA
Inferred from Electronic Annotation
more info
 
cell death ISO
Inferred from Sequence Orthology
more info
 
cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
cellular lipid metabolic process ISO
Inferred from Sequence Orthology
more info
 
cellular localization ISO
Inferred from Sequence Orthology
more info
 
cellular response to heat ISO
Inferred from Sequence Orthology
more info
 
cellular response to unfolded protein ISO
Inferred from Sequence Orthology
more info
 
cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
 
fibroblast migration ISO
Inferred from Sequence Orthology
more info
 
gene expression ISO
Inferred from Sequence Orthology
more info
 
gliogenesis ISO
Inferred from Sequence Orthology
more info
 
immune response ISO
Inferred from Sequence Orthology
more info
 
lamellipodium assembly ISO
Inferred from Sequence Orthology
more info
 
mating ISO
Inferred from Sequence Orthology
more info
 
membrane raft organization ISO
Inferred from Sequence Orthology
more info
 
motor behavior ISO
Inferred from Sequence Orthology
more info
 
multicellular organism aging ISO
Inferred from Sequence Orthology
more info
 
multicellular organism growth ISO
Inferred from Sequence Orthology
more info
 
muscle fiber development ISO
Inferred from Sequence Orthology
more info
 
myelin assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
myelin assembly ISO
Inferred from Sequence Orthology
more info
 
myelination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
myelination IDA
Inferred from Direct Assay
more info
PubMed 
myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
myelination ISO
Inferred from Sequence Orthology
more info
 
myelination in peripheral nervous system ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
neuromuscular junction development, skeletal muscle fiber ISO
Inferred from Sequence Orthology
more info
 
neuromuscular process ISO
Inferred from Sequence Orthology
more info
 
neuronal action potential ISO
Inferred from Sequence Orthology
more info
 
neuronal action potential propagation ISO
Inferred from Sequence Orthology
more info
 
neuronal ion channel clustering ISO
Inferred from Sequence Orthology
more info
 
paranodal junction assembly ISO
Inferred from Sequence Orthology
more info
 
peripheral nervous system development IC
Inferred by Curator
more info
PubMed 
peripheral nervous system development ISO
Inferred from Sequence Orthology
more info
 
peripheral nervous system neuron axonogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
proteasomal protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
protein complex oligomerization ISO
Inferred from Sequence Orthology
more info
 
regulation of Schwann cell proliferation ISO
Inferred from Sequence Orthology
more info
 
regulation of apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
regulation of glial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
regulation of protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
response to bacterium ISO
Inferred from Sequence Orthology
more info
 
response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
 
striated muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
transmission of nerve impulse ISO
Inferred from Sequence Orthology
more info
 
vestibular reflex ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
bicellular tight junction IDA
Inferred from Direct Assay
more info
PubMed 
cell surface ISO
Inferred from Sequence Orthology
more info
 
compact myelin IDA
Inferred from Direct Assay
more info
PubMed 
compact myelin ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
integrin complex ISO
Inferred from Sequence Orthology
more info
 
laminin complex ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
peripheral myelin protein 22
Names
PMP-22
SAG
SR13 myelin protein
schwann cell membrane glycoprotein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017037.1NP_058733.1  peripheral myelin protein 22

    See identical proteins and their annotated locations for NP_058733.1

    Status: PROVISIONAL

    Source sequence(s)
    X62431
    UniProtKB/Swiss-Prot
    P25094
    Related
    ENSRNOP00000069909.1, ENSRNOT00000081415.1
    Conserved Domains (1) summary
    pfam00822
    Location:1153
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

    Range
    49538588..49568583
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006246584.3XP_006246646.1  peripheral myelin protein 22 isoform X1

    See identical proteins and their annotated locations for XP_006246646.1

    UniProtKB/Swiss-Prot
    P25094
    Related
    ENSRNOP00000051201.1, ENSRNOT00000041606.3
    Conserved Domains (1) summary
    pfam00822
    Location:1153
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

Alternate Rn_Celera

Genomic

  1. AC_000078.1 Alternate Rn_Celera

    Range
    47038544..47068443
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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