Pmch pro-melanin-concentrating hormone [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pmchprovided by RGD
Official Full Name: pro-melanin-concentrating hormoneprovided by RGD
Primary source: RGD:3358
See related: Ensembl:ENSRNOG00000066777 AllianceGenome:RGD:3358
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables type 1 melanin-concentrating hormone receptor binding activity. Involved in several processes, including lactation; modulation of chemical synaptic transmission; and positive regulation of circadian sleep/wake cycle, REM sleep. Located in extracellular space. Biomarker of obesity and sleeping sickness. Orthologous to several human genes including PMCH (pro-melanin concentrating hormone). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in Brain (RPKM 183.5), Thymus (RPKM 44.2) and 3 other tissues See more
Orthologs: all
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Genomic context

Location:: 7q13

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (24399404..24400720)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (22511934..22513250)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Acute intrahippocampal administration of melanin-concentrating hormone impairs memory consolidation and decreases the expression of MCHR-1 and TrkB receptors.
Title: Acute intrahippocampal administration of melanin-concentrating hormone impairs memory consolidation and decreases the expression of MCHR-1 and TrkB receptors.
Prolactin maintains transient melanin-concentrating hormone expression in the medial preoptic area during established lactation.
Title: Prolactin maintains transient melanin-concentrating hormone expression in the medial preoptic area during established lactation.
Characterisation and origins of melanin-concentrating hormone immunoreactive fibres of the posterior lobe of the pituitary and median eminence during lactation in the Long-Evans rat.
Title: Characterisation and origins of melanin-concentrating hormone immunoreactive fibres of the posterior lobe of the pituitary and median eminence during lactation in the Long-Evans rat.
A hypothalamus to telencephalon neural pathway for regulating impulsivity involved communication from melanin-concentrating hormone (MCH)-expressing lateral hypothalamic neurons to the ventral hippocampus subregion.
Title: Hypothalamus-hippocampus circuitry regulates impulsivity via melanin-concentrating hormone.
results show that the number of Melanin Concentrating hormone-immunoreactive neurons in the Medial Preoptic Area is positively correlated with the number of pups in the litter and that artificially reducing the number of pups can also decrease the number of MCH-immunoreactive neurons in the MPOA.
Title: Litter size determines the number of melanin-concentrating hormone neurons in the medial preoptic area of Sprague Dawley lactating dams.
our findings demonstrate that NEI, a cleaved peptide from the same precursor, prepro-MCH, as MCH, induce REM sleep at least in part through acting on the vlPAG
Title: Neuropeptide glutamic acid-isoleucine (NEI)-induced paradoxical sleep in rats.
MCH levels in the CSF, brain preproMCH and MCHR1 gene expression during paradoxical sleep deprivation, sleep rebound and chronic sleep restriction were studied in rats.
Title: MCH levels in the CSF, brain preproMCH and MCHR1 gene expression during paradoxical sleep deprivation, sleep rebound and chronic sleep restriction.
MCH participates not only in the regulation of glucose and sleep-wake homeostasis but also the vigilance-state dependent regulation of the central hypercapnic chemoreflex and respiratory control.
Title: The role of melanin concentrating hormone (MCH) in the central chemoreflex: a knockdown study by siRNA in the lateral hypothalamus in rats.
modulation of mPOA function by MCH may contribute to the weaning of maternal responsiveness characteristic of the late postpartum period.
Title: Melanin-concentrating hormone in the medial preoptic area reduces active components of maternal behavior in rats.
Results indicate that melanin-concentrating hormone and orexin peptides play physiologically distinct roles in feeding behavior.
Title: Expression of phosphorylated cyclic AMP response element-binding protein in melanin-concentrating hormone neurons and orexin neurons in male and female rats during ad-libitum feeding.

Submit: New GeneRIF Correction See all GeneRIFs (35)

General gene information

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Markers

AI503644 (e-PCR)
- UniSTS:164447

RH137732 (e-PCR)
- UniSTS:219819

RH94549 (e-PCR)
- UniSTS:119797

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables melanin-concentrating hormone activity	IEA Inferred from Electronic Annotation more info
enables melanin-concentrating hormone activity	ISO Inferred from Sequence Orthology more info
enables type 1 melanin-concentrating hormone receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables type 1 melanin-concentrating hormone receptor binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in drinking behavior	IDA Inferred from Direct Assay more info	PubMed
involved_in feeding behavior	IDA Inferred from Direct Assay more info	PubMed
involved_in feeding behavior	ISO Inferred from Sequence Orthology more info
involved_in feeding behavior	ISS Inferred from Sequence or Structural Similarity more info
involved_in lactation	IEP Inferred from Expression Pattern more info	PubMed
involved_in learning or memory	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of blood pressure	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of synaptic transmission, dopaminergic	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of synaptic transmission, dopaminergic	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of circadian sleep/wake cycle, REM sleep	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of feeding behavior	ISO Inferred from Sequence Orthology more info
involved_in regulation of heart rate	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of neuronal synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: pro-MCH

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012625.2 → NP_036757.2 pro-MCH precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

P14200

UniProtKB/TrEMBL

A0A8I6ABX9

Related

ENSRNOP00000091581.1, ENSRNOT00000095213.2

Conserved Domains (1) summary

pfam05824
Location:83 → 165

Pro-MCH; Pro-melanin-concentrating hormone (Pro-MCH)