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CG30025 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 246398, updated on 6-Jul-2026
Official Symbol
CG30025provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0050025
Locus tag
Dmel_CG30025
See related
AllianceGenome:FB:FBgn0050025
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG30025; SP215
Summary
Enables serine hydrolase activity. Predicted to be involved in proteolysis. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 2A1 and prostate cancer. Orthologous to several human genes including KLK12 (kallikrein related peptidase 12); KLK4 (kallikrein related peptidase 4); and KLK9 (kallikrein related peptidase 9). [provided by Alliance of Genome Resources, Jul 2025]
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Try the new Transcripts and proteins table
See CG30025 in Genome Data Viewer
Location:
47F4-47F5; 2-64 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11353564..11354373, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7241069..7241878, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene gammaTrypsin Neighboring gene uncharacterized protein Neighboring gene deltaTrypsin Neighboring gene uncharacterized protein Neighboring gene iotaTrypsin

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Protease gene duplication and proteolytic activity in Drosophila female reproductive tracts. Kelleher ES, et al. Mol Biol Evol, 2009 Sep. PMID 19546158, Free PMC Article
  2. A novel interplay between the ubiquitin–proteasome system and serine proteases during Drosophila development. Lipinszki Z, et al. Biochem J, 2013 Sep 15. PMID 23805892
  3. Changes in Neuronal Signaling and Cell Stress Response Pathways are Associated with a Multigenic Response of Drosophila melanogaster to DDT Selection. Seong KM, et al. Genome Biol Evol, 2017 Dec 1. PMID 29211847, Free PMC Article
  4. Damage sensing mediated by serine proteases Hayan and Persephone for Toll pathway activation in apoptosis-deficient flies. Nakano S, et al. PLoS Genet, 2023 Jun. PMID 37319131, Free PMC Article
  5. Building a platform for predicting functions of serine protease-related proteins in Drosophila melanogaster and other insects. Cao X, et al. Insect Biochem Mol Biol, 2018 Dec. PMID 30367934, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine hydrolase activity HDA PubMed 
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis ISM
Inferred from Sequence Model
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
uncharacterized protein
Names
CG30025-PA
NP_725036.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    11353564..11354373 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_165825.2 → NP_725036.1  uncharacterized protein Dmel_CG30025

    See identical proteins and their annotated locations for NP_725036.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z8J8, G2J5V1
    Related
    FBpp0087254
    Conserved Domains (2) summary
    smart00020
    Location:30 → 249
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:31 → 252
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1Z8J8 A1Z8J8

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