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Zdhhc2 zinc finger DHHC-type palmitoyltransferase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 246326, updated on 30-Sep-2021

Summary

Official Symbol
Zdhhc2provided by RGD
Official Full Name
zinc finger DHHC-type palmitoyltransferase 2provided by RGD
Primary source
RGD:628681
See related
EnsemblRapid:ENSRNOG00000022686
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
srec; DHHC2
Expression
Biased expression in Brain (RPKM 171.9), Heart (RPKM 145.0) and 9 other tissues See more
Orthologs
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Genomic context

See Zdhhc2 in Genome Data Viewer
Location:
16q12.1
Exon count:
13
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (51808465..51878060, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (54932546..55002322, complement)

Chromosome 16 - NC_051351.1Genomic Context describing neighboring genes Neighboring gene VPS37A subunit of ESCRT-I Neighboring gene CCR4-NOT transcription complex, subunit 7 Neighboring gene mitochondrial calcium uptake family, member 3 Neighboring gene fibroblast growth factor 20

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables palmitoyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-cysteine S-myristoyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein-cysteine S-palmitoyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-cysteine S-stearoyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in peptidyl-L-cysteine S-palmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-L-cysteine S-palmitoylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-L-cysteine S-palmitoylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of AMPA glutamate receptor clustering IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of endosome to plasma membrane protein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to postsynaptic membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein palmitoylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein palmitoylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell-cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of neuronal synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in synaptic vesicle maturation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic recycling endosome ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic recycling endosome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in recycling endosome membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
palmitoyltransferase ZDHHC2
Names
DHHC-2
acyltransferase ZDHHC2
membrane-associated DHHC2 zinc finger protein
rec
small rec
zinc finger DHHC domain-containing protein 2
zinc finger, DHHC domain containing 2
zinc finger, DHHC-type containing 2
NP_659564.3
XP_008769510.1
XP_038950125.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145096.3NP_659564.3  palmitoyltransferase ZDHHC2

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000283
    Related
    ENSRNOP00000084203.1, ENSRNOT00000119635.1
    Conserved Domains (1) summary
    cl19890
    Location:19301
    DHHC; DHHC palmitoyltransferase

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051351.1 Reference mRatBN7.2 Primary Assembly

    Range
    51808465..51878060 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008771288.3XP_008769510.1  palmitoyltransferase ZDHHC2 isoform X1

    Conserved Domains (1) summary
    pfam01529
    Location:126247
    zf-DHHC; DHHC palmitoyltransferase
  2. XM_039094197.1XP_038950125.1  palmitoyltransferase ZDHHC2 isoform X2

    Conserved Domains (1) summary
    pfam01529
    Location:6127
    DHHC; DHHC palmitoyltransferase
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