Zdhhc2 zinc finger DHHC-type palmitoyltransferase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Zdhhc2provided by RGD
Official Full Name: zinc finger DHHC-type palmitoyltransferase 2provided by RGD
Primary source: RGD:628681
See related: Ensembl:ENSRNOG00000022686 AllianceGenome:RGD:628681
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: srec; DHHC2
Summary: Predicted to enable protein homodimerization activity and protein-cysteine S-acyltransferase activity. Involved in several processes, including positive regulation of protein localization to membrane; protein localization to cell periphery; and regulation of synaptic plasticity. Is active in glutamatergic synapse and postsynaptic density. Orthologous to human ZDHHC2 (zinc finger DHHC-type palmitoyltransferase 2). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in Brain (RPKM 171.9), Heart (RPKM 145.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16q12.1

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (58511931..58581530, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (51808465..51878060, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (54932546..55002322, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

knockdown of DHHC2 in rat hippocampal neurons disrupted exocytosis from recycling endosomes, enlargement of dendritic spines, AKAP recruitment to spines, and potentiation of AMPAR-mediated synaptic currents.
Title: The palmitoyl acyltransferase DHHC2 regulates recycling endosome exocytosis and synaptic potentiation through palmitoylation of AKAP79/150.
Gi/o signaling and the palmitoyltransferase DHHC2 regulate palmitate cycling and shuttling of RGS7 family-binding protein.
Title: Gi/o signaling and the palmitoyltransferase DHHC2 regulate palmitate cycling and shuttling of RGS7 family-binding protein.

Submit: New GeneRIF Correction

General gene information

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Markers

AU047323 (e-PCR)
- UniSTS:110621

BM388073 (e-PCR)
- UniSTS:261450

BE114229 (e-PCR)
- UniSTS:247459

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables palmitoyltransferase activity	IEA Inferred from Electronic Annotation more info
enables palmitoyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein-cysteine S-myristoyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-cysteine S-myristoyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein-cysteine S-palmitoyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-cysteine S-palmitoyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-cysteine S-palmitoyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein-cysteine S-stearoyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-cysteine S-stearoyltransferase activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in peptidyl-L-cysteine S-palmitoylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of AMPA glutamate receptor clustering	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endosome to plasma membrane protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of long-term synaptic potentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within postsynaptic neurotransmitter receptor cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within postsynaptic neurotransmitter receptor cycle	ISO Inferred from Sequence Orthology more info
involved_in protein localization to membrane raft	IEA Inferred from Electronic Annotation more info
involved_in protein localization to membrane raft	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in protein localization to postsynaptic membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein targeting to membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell-cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of neuronal synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of postsynaptic neurotransmitter receptor diffusion trapping	EXP Inferred from Experiment more info	PubMed
involved_in regulation of postsynaptic neurotransmitter receptor diffusion trapping	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic neurotransmitter receptor diffusion trapping	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of protein localization to plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in synapse assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within synapse assembly	IEA Inferred from Electronic Annotation more info
involved_in synapse assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle maturation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in endosome	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynaptic density	EXP Inferred from Experiment more info	PubMed
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic recycling endosome	IEA Inferred from Electronic Annotation more info
located_in postsynaptic recycling endosome	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic recycling endosome	ISO Inferred from Sequence Orthology more info
located_in postsynaptic recycling endosome	ISO Inferred from Sequence Orthology more info
located_in postsynaptic recycling endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in postsynaptic recycling endosome membrane	IEA Inferred from Electronic Annotation more info
located_in recycling endosome membrane	IEA Inferred from Electronic Annotation more info
located_in recycling endosome membrane	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: palmitoyltransferase ZDHHC2

Names: DHHC-2; acyltransferase ZDHHC2; membrane-associated DHHC2 zinc finger protein; rec; small rec; zinc finger DHHC domain-containing protein 2; zinc finger, DHHC domain containing 2; zinc finger, DHHC-type containing 2

NP_659564.3

EC 2.3.1.225

XP_008769510.1

EC 2.3.1.225

XP_038950125.1

EC 2.3.1.225

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145096.3 → NP_659564.3 palmitoyltransferase ZDHHC2

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000016

UniProtKB/Swiss-Prot

A0P8F1, Q9JKR5

UniProtKB/TrEMBL

Q2TGK4

Related

ENSRNOP00000084203.1, ENSRNOT00000119635.2

Conserved Domains (1) summary

cl19890
Location:19 → 301

DHHC; DHHC palmitoyltransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

58511931..58581530 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008771288.4 → XP_008769510.1 palmitoyltransferase ZDHHC2 isoform X1

UniProtKB/TrEMBL

Q2TGK4

Related

ENSRNOP00000099943.1, ENSRNOT00000128608.1

Conserved Domains (1) summary

pfam01529
Location:126 → 247

zf-DHHC; DHHC palmitoyltransferase
XM_039094197.2 → XP_038950125.1 palmitoyltransferase ZDHHC2 isoform X2

Conserved Domains (1) summary

pfam01529
Location:6 → 127

DHHC; DHHC palmitoyltransferase