U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Csad cysteine sulfinic acid decarboxylase [ Mus musculus (house mouse) ]

Gene ID: 246277, updated on 27-Nov-2024

Summary

Official Symbol
Csadprovided by MGI
Official Full Name
cysteine sulfinic acid decarboxylaseprovided by MGI
Primary source
MGI:MGI:2180098
See related
Ensembl:ENSMUSG00000023044 AllianceGenome:MGI:2180098
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Csd
Summary
Predicted to enable sulfinoalanine decarboxylase activity. Acts upstream of or within taurine biosynthetic process. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; placenta; and sensory organ. Orthologous to human CSAD (cysteine sulfinic acid decarboxylase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in liver E18 (RPKM 36.1), mammary gland adult (RPKM 27.1) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Csad in Genome Data Viewer
Location:
15 F2; 15 57.35 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (102085432..102112685, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (102176997..102205052, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene insulin-like growth factor binding protein 6 Neighboring gene sterol O-acyltransferase 2 Neighboring gene STARR-positive B cell enhancer ABC_E5519 Neighboring gene STARR-seq mESC enhancer starr_39822 Neighboring gene zinc finger protein 740 Neighboring gene STARR-positive B cell enhancer mm9_chr15:102055434-102055734 Neighboring gene STARR-positive B cell enhancer mm9_chr15:102055789-102056089 Neighboring gene integrin beta 7 Neighboring gene STARR-seq mESC enhancer starr_39826 Neighboring gene STARR-seq mESC enhancer starr_39827 Neighboring gene retinoic acid receptor, gamma Neighboring gene STARR-seq mESC enhancer starr_39828

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aspartate 1-decarboxylase activity IEA
Inferred from Electronic Annotation
more info
 
enables carboxy-lyase activity TAS
Traceable Author Statement
more info
PubMed 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
 
enables sulfinoalanine decarboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables sulfinoalanine decarboxylase activity ISO
Inferred from Sequence Orthology
more info
 
enables sulfinoalanine decarboxylase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
cysteine sulfinic acid decarboxylase
Names
aspartate 1-decarboxylase
cysteine-sulfinate decarboxylase
sulfinoalanine decarboxylase
NP_001346055.1
NP_001346056.1
NP_001346057.1
NP_001403380.1
NP_001403381.1
NP_001403382.1
NP_001403383.1
NP_001403384.1
NP_001403385.1
NP_001403386.1
NP_001403387.1
NP_001403388.1
NP_001403389.1
NP_001403390.1
NP_001403391.1
NP_001403392.1
NP_001403393.1
NP_001403394.1
NP_001403395.1
NP_001403396.1
NP_001403397.1
NP_001403398.1
NP_001403399.1
NP_001403400.1
NP_001403401.1
NP_001403402.1
NP_001403403.1
NP_001403404.1
NP_659191.1
XP_030104442.1
XP_030104445.1
XP_030104446.1
XP_036015310.1
XP_036015312.1
XP_036015314.1
XP_036015316.1
XP_036015317.1
XP_036015318.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359126.2NP_001346055.1  cysteine sulfinic acid decarboxylase isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC123791
    Consensus CDS
    CCDS27873.1
    UniProtKB/Swiss-Prot
    Q8K566, Q9DBE0
    Conserved Domains (1) summary
    cd06450
    Location:89481
    DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...
  2. NM_001359127.1NP_001346056.1  cysteine sulfinic acid decarboxylase isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. This results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AC123791
    Conserved Domains (1) summary
    cl18945
    Location:49382
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
  3. NM_001359128.2NP_001346057.1  cysteine sulfinic acid decarboxylase isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks exons in the coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AC123791
    Conserved Domains (1) summary
    cl18945
    Location:49382
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
  4. NM_001416451.1NP_001403380.1  cysteine sulfinic acid decarboxylase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC123791
    UniProtKB/Swiss-Prot
    Q8K566, Q9DBE0
  5. NM_001416452.1NP_001403381.1  cysteine sulfinic acid decarboxylase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC123791
    UniProtKB/Swiss-Prot
    Q8K566, Q9DBE0
  6. NM_001416453.1NP_001403382.1  cysteine sulfinic acid decarboxylase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC123791
    UniProtKB/Swiss-Prot
    Q8K566, Q9DBE0
  7. NM_001416454.1NP_001403383.1  cysteine sulfinic acid decarboxylase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC123791
    UniProtKB/Swiss-Prot
    Q8K566, Q9DBE0
  8. NM_001416455.1NP_001403384.1  cysteine sulfinic acid decarboxylase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC123791
    UniProtKB/Swiss-Prot
    Q8K566, Q9DBE0
  9. NM_001416456.1NP_001403385.1  cysteine sulfinic acid decarboxylase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC123791
    UniProtKB/Swiss-Prot
    Q8K566, Q9DBE0
  10. NM_001416457.1NP_001403386.1  cysteine sulfinic acid decarboxylase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC123791
    UniProtKB/Swiss-Prot
    Q8K566, Q9DBE0
  11. NM_001416458.1NP_001403387.1  cysteine sulfinic acid decarboxylase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC123791
    UniProtKB/Swiss-Prot
    Q8K566, Q9DBE0
  12. NM_001416459.1NP_001403388.1  cysteine sulfinic acid decarboxylase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC123791
    UniProtKB/Swiss-Prot
    Q8K566, Q9DBE0
  13. NM_001416460.1NP_001403389.1  cysteine sulfinic acid decarboxylase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC123791
    UniProtKB/Swiss-Prot
    Q8K566, Q9DBE0
  14. NM_001416461.1NP_001403390.1  cysteine sulfinic acid decarboxylase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC123791
    UniProtKB/Swiss-Prot
    Q8K566, Q9DBE0
  15. NM_001416462.1NP_001403391.1  cysteine sulfinic acid decarboxylase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC123791
    UniProtKB/Swiss-Prot
    Q8K566, Q9DBE0
  16. NM_001416463.1NP_001403392.1  cysteine sulfinic acid decarboxylase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC123791
    UniProtKB/TrEMBL
    A0A2R8VHX0
  17. NM_001416464.1NP_001403393.1  cysteine sulfinic acid decarboxylase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC123791
    UniProtKB/TrEMBL
    A0A2R8VHX0
    Related
    ENSMUSP00000155492.2, ENSMUST00000230288.2
  18. NM_001416465.1NP_001403394.1  cysteine sulfinic acid decarboxylase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC123791
    UniProtKB/TrEMBL
    A0A2R8VHX0
  19. NM_001416466.1NP_001403395.1  cysteine sulfinic acid decarboxylase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC123791
    UniProtKB/TrEMBL
    A0A2R8VHX0
  20. NM_001416467.1NP_001403396.1  cysteine sulfinic acid decarboxylase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC123791
    UniProtKB/TrEMBL
    A0A2R8VHX0
  21. NM_001416468.1NP_001403397.1  cysteine sulfinic acid decarboxylase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC123791
  22. NM_001416469.1NP_001403398.1  cysteine sulfinic acid decarboxylase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC123791
  23. NM_001416470.1NP_001403399.1  cysteine sulfinic acid decarboxylase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC123791
  24. NM_001416471.1NP_001403400.1  cysteine sulfinic acid decarboxylase isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC123791
  25. NM_001416472.1NP_001403401.1  cysteine sulfinic acid decarboxylase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC123791
  26. NM_001416473.1NP_001403402.1  cysteine sulfinic acid decarboxylase isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC123791
  27. NM_001416474.1NP_001403403.1  cysteine sulfinic acid decarboxylase isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC123791
  28. NM_001416475.1NP_001403404.1  cysteine sulfinic acid decarboxylase isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC123791
  29. NM_144942.4NP_659191.1  cysteine sulfinic acid decarboxylase isoform 1

    See identical proteins and their annotated locations for NP_659191.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC123791
    Consensus CDS
    CCDS27873.1
    UniProtKB/Swiss-Prot
    Q8K566, Q9DBE0
    Related
    ENSMUSP00000023805.2, ENSMUST00000023805.3
    Conserved Domains (1) summary
    cd06450
    Location:89481
    DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...

RNA

  1. NR_183985.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC123791
  2. NR_183986.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC123791
  3. NR_183987.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC123791

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    102085432..102112685 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248585.1XP_030104445.1  cysteine sulfinic acid decarboxylase isoform X3

    Conserved Domains (1) summary
    cl18945
    Location:49382
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
  2. XM_036159419.1XP_036015312.1  cysteine sulfinic acid decarboxylase isoform X1

    UniProtKB/Swiss-Prot
    Q8K566, Q9DBE0
    Conserved Domains (1) summary
    cd06450
    Location:89481
    DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...
  3. XM_036159424.1XP_036015317.1  cysteine sulfinic acid decarboxylase isoform X2

    UniProtKB/TrEMBL
    A0A2R8VHX0
    Conserved Domains (1) summary
    cd06450
    Location:89451
    DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...
  4. XM_036159423.1XP_036015316.1  cysteine sulfinic acid decarboxylase isoform X2

    UniProtKB/TrEMBL
    A0A2R8VHX0
    Conserved Domains (1) summary
    cd06450
    Location:89451
    DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...
  5. XM_036159425.1XP_036015318.1  cysteine sulfinic acid decarboxylase isoform X3

    Conserved Domains (1) summary
    cl18945
    Location:49382
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
  6. XM_036159421.1XP_036015314.1  cysteine sulfinic acid decarboxylase isoform X1

    UniProtKB/Swiss-Prot
    Q8K566, Q9DBE0
    Conserved Domains (1) summary
    cd06450
    Location:89481
    DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...
  7. XM_036159417.1XP_036015310.1  cysteine sulfinic acid decarboxylase isoform X1

    UniProtKB/Swiss-Prot
    Q8K566, Q9DBE0
    Conserved Domains (1) summary
    cd06450
    Location:89481
    DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...
  8. XM_030248582.2XP_030104442.1  cysteine sulfinic acid decarboxylase isoform X2

    UniProtKB/TrEMBL
    A0A2R8VHX0
    Conserved Domains (1) summary
    cd06450
    Location:89451
    DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...
  9. XM_030248586.2XP_030104446.1  cysteine sulfinic acid decarboxylase isoform X4

    Conserved Domains (1) summary
    cl18945
    Location:49382
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

RNA

  1. XR_003951395.1 RNA Sequence

  2. XR_003951393.1 RNA Sequence

  3. XR_004938838.1 RNA Sequence

  4. XR_004938839.1 RNA Sequence

  5. XR_003951396.2 RNA Sequence